The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Membrane Compartmentation Is Required for Efficient T Cell Activation
Abstract
The plasma membrane of mammalian cells contains detergent-resistant membrane rafts enriched in glycosphingolipids and cholesterol. Although several important signaling molecules have been found in such rafts, evidence documenting a functional role for their localization has been scarce. Using a fractionation scheme that preserves tyrosine phosphorylation, we show that T cell activation leads to a striking compartmentation in the rafts of activated T cell receptor and associated signal-transducing molecules. Conditions that reversibly disrupt raft structure either by dispersing their contents or by forcing their internalization reversibly disrupt the earliest steps of T cell activation. Thus, raft integrity is a prerequisite for efficient T cell receptor signal transduction.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Previous studies have implicated the translocation of Lck, ZAP-70 and the TCR into the IS in effective TCR signaling [29], [30], [31].”
From RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling (2010) · cites this paper as [31]
Citations
Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
Brown, D. A., & Rose, J. K. (1992) · Cell · doi:10.1016/0092-8674(92)90189-j · Cited by 2,921
Caveolin, a protein component of caveolae membrane coats
Rothberg, K. G., Heuser, J. E., Donzell, W. C., Ying, Y., Glenney, J. R., & Anderson, R. G. W. (1992) · Cell · doi:10.1016/0092-8674(92)90143-z · Cited by 2,259
Signal transduction by lymphocyte antigen receptors
Weiss, A., & Littman, D. R. (1994) · Cell · doi:10.1016/0092-8674(94)90334-4 · Cited by 2,089
rab5 controls early endosome fusion in vitro
Gorvel, J., Chavrier, P., Zerial, M., & Gruenberg, J. E. (1991) · Cell · doi:10.1016/0092-8674(91)90316-q · Cited by 1,094
Song, K. S., Li, S. C., Okamoto, T., Quilliam, L. A., Sargiacomo, M., & Lisanti, M. P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9690 · Cited by 1,000
Sargiacomo, M., Sudol, M., Tang, Z., & Lisanti, M. (1993) · The Journal of cell biology · doi:10.1083/jcb.122.4.789 · Cited by 953
Schnitzer, J. E., Oh, P., Pinney, E., & Allard, J. F. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.5.1217 · Cited by 928
Lisanti, M. P., Scherer, P. E., Vidugiriene, J., Tang, Z., Hermanowski-Vosatka, A., Tu, Y. H., Cook, R. F., & Sargiacomo, M. (1994) · The Journal of cell biology · doi:10.1083/jcb.126.1.111 · Cited by 906
GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases
Štefanová, I., Hořejšı́, V., Ansotegui, I. J., Knapp, W., & Stockinger, H. S. J. (1991) · Science · doi:10.1126/science.1719635 · Cited by 826
Cited by
Lipid rafts and signal transduction
Simons, K., & Toomre, D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 5,371
CD28 and CTLA-4 coreceptor expression and signal transduction
Rudd, C. E., Taylor, A., & Schneider, H. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00770.x · Cited by 898
Dustin, M. L. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0161 · Cited by 502
Signal transduction by the TCR for antigen
Kane, L. P., Lin, J., & Weiss, A. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00083-2 · Cited by 498
Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling.
Rudd, C. E., & Schneider, H. (2003) · Nature Reviews Immunology · doi:10.1038/nri1131 · Cited by 392
Metadata
- Authors
- Xavier, R., Brennan, T., Li, Q., McCormack, C., & Seed, B.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1998-06
- Volume
- 8
- Issue
- 6
- Pages
- 723-732
- ISSN
- 1074-7613
- Cited by
- 690
- References
- 90
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 5525 d)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Membrane Compartmentation Is Required for Efficient T Cell Activation. https://app.cochat.ai/papers/10.1016/s1074-7613(00)80577-4
- The paper
- Xavier, R., Brennan, T., Li, Q., McCormack, C., & Seed, B. (1998). Membrane Compartmentation Is Required for Efficient T Cell Activation. Immunity. https://doi.org/10.1016/s1074-7613(00)80577-4
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
