The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Caveolae-deficient Endothelial Cells Show Defects in the Uptake and Transport of Albumin in Vivo
Open accessAbstract
The role of endothelial cell caveolae in the uptake and transport of macromolecules from the blood-space to the tissue-space remains controversial. To address this issue directly, we employed caveolin-1 gene knock-out mice that lack caveolin-1 protein expression and caveolae organelles. Here, we show that endothelial cell caveolae are required for the efficient uptake and transport of a known caveolar ligand, i.e. albumin, in vivo. Caveolin-1-null mice were perfused with 5-nm gold-conjugated albumin, and its uptake was followed by transmission electron microscopy. Our results indicate that gold-conjugated albumin is not endocytosed by Cav-1-deficient lung endothelial cells and remains in the blood vessel lumen; in contrast, gold-conjugated albumin was concentrated and internalized by lung endothelial cell caveolae in wild-type mice, as expected. To quantitate this defect in uptake, we next studied the endocytosis of radioiodinated albumin using aortic ring segments from wild-type and Cav-1-null mice. Interestingly, little or no uptake of radioiodinated albumin was observed in the aortic segments from Cav-1-deficient mice, whereas aortic segments from wild-type mice showed robust uptake that was time- and temperature-dependent and competed by unlabeled albumin. We conclude that endothelial cell caveolae are required for the efficient uptake and transport of albumin from the blood to the interstitium.
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Cites
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Self-citationCaveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities
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Self-citationVIP21/caveolin is a cholesterol-binding protein.
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THE FINE STRUCTURE OF THE GALL BLADDER EPITHELIUM OF THE MOUSE
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The multiple faces of caveolae
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Aird, W. C. (2007) · Circulation Research · doi:10.1161/01.res.0000255690.03436.ae · Cited by 1,257
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Metadata
- Authors
- Schubert, W., Frank, P. G., Razani, B., Park, D. S., Chow, C.-W., & Lisanti, M. P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 276
- Issue
- 52
- Pages
- 48619-48622
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2019862207
- Cited by
- 337
- References
- 47
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Schubert, W., Frank, P. G., Razani, B., Park, D. S., Chow, C.-W., & Lisanti, M. P. (2001). Caveolae-deficient Endothelial Cells Show Defects in the Uptake and Transport of Albumin in Vivo. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.c100613200
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