Cited by 203Protein Hydrolysis and Bioactive PeptidesNeuropeptides and Animal PhysiologyChemical Synthesis and Analysis

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Stimulation of human peripheral blood lymphocytes by bioactive peptides derived from bovine milk proteins.

Kayser, Holger, Meisel, Hans·1996·FEBS Letters

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Abstract

The in vitro modulation of the proliferation of human peripheral blood lymphocytes of different synthetic peptides derived from milk proteins was investigated. Therefore, proliferation changes were followed up after incorporation of BrdU into the DNA, and the influence on protein biosynthesis was measured using the [3 H]leucine incorporation test. Tyr‐Gly and Tyr‐Gly‐Gly significantly enhanced (maximal 90 and 35%, respectively) the proliferation of PBL. For β‐casomorphin‐7 and β‐casokinin‐10, lymphocyte proliferation was suppressed at lower concentrations, but stimulated at higher concentrations (≥10−7 mol/l). Protein synthesis was stimulated (maxima at 25%) only with Tyr‐Gly and Tyr‐Gly‐Gly. The findings point to a need for further studies on the possible function of peptides derived from milk proteins as orally bioavailable immunopotentiatory compounds.

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Authors: Kayser, H., & Meisel, H.
Affiliations: Christian-Albrechts-Universität zu Kiel (DE)
Venue: FEBS Letters
Publisher: Wiley
Published: 1996-03-25
Volume: 383
Issue: 1-2
Pages: 18-20
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/0014-5793(96)00207-4
OpenAlex: W1999372506
Cited by: 203
References: 13
Citations by year: 2026: 5 · 2025: 5 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 9 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 11 · 2015: 5 · 2014: 11 · 2013: 9 · 2012: 8
FWCI: 1.01
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1345 d)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
Keywords: bovine milk proteins, lymphocyte proliferation, peripheral blood lymphocytes, beta-casomorphin-7, protein synthesis, immunopotentiators, oral bioavailability, immunomodulation
MeSH terms: Amino Acid Sequence, Bromodeoxyuridine, Caseins, Cell Division, Concanavalin A, Dipeptides, DNA, Endorphins, Humans, Leucine, Lymphocyte Activation, Lymphocytes, Milk Proteins, Molecular Sequence Data, Oligopeptides, Peptide Fragments

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Stimulation of human peripheral blood lymphocytes by bioactive peptides derived from bovine milk proteins.

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