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Cited by 203Protein Hydrolysis and Bioactive PeptidesNeuropeptides and Animal PhysiologyChemical Synthesis and Analysis

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Stimulation of human peripheral blood lymphocytes by bioactive peptides derived from bovine milk proteins.

Kayser, Holger, Meisel, Hans·1996·FEBS Letters
DOI 10.1016/0014-5793(96)00207-4
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Abstract

The in vitro modulation of the proliferation of human peripheral blood lymphocytes of different synthetic peptides derived from milk proteins was investigated. Therefore, proliferation changes were followed up after incorporation of BrdU into the DNA, and the influence on protein biosynthesis was measured using the [3 H]leucine incorporation test. Tyr‐Gly and Tyr‐Gly‐Gly significantly enhanced (maximal 90 and 35%, respectively) the proliferation of PBL. For β‐casomorphin‐7 and β‐casokinin‐10, lymphocyte proliferation was suppressed at lower concentrations, but stimulated at higher concentrations (≥10−7 mol/l). Protein synthesis was stimulated (maxima at 25%) only with Tyr‐Gly and Tyr‐Gly‐Gly. The findings point to a need for further studies on the possible function of peptides derived from milk proteins as orally bioavailable immunopotentiatory compounds.

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Crossref · 10.1016/0014-5793(96)00207-4

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13 of 13 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 4

  1. Teschemacher H., 1994, β-Casomorphins and Related Peptides: Recent Developments, 3
  2. Meisel H., 1993, Food Proteins — Structure Functionality, 67
  3. Tzehoval E., 1978, Proc. Natl. Acad. Sci. USA, 3400
  4. Paegelow I., 1986, Methods Find. Exp. Clin Pharmacol., 8, 91

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Metadata

Authors
Kayser, H., & Meisel, H.
Affiliations
Christian-Albrechts-Universität zu Kiel (DE)
Venue
FEBS Letters
Publisher
Wiley
Published
1996-03-25
Volume
383
Issue
1-2
Pages
18-20
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
DOI
10.1016/0014-5793(96)00207-4
OpenAlex
W1999372506
Cited by
203
References
13
Citations by year
2026: 5 · 2025: 5 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 9 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 11 · 2015: 5 · 2014: 11 · 2013: 9 · 2012: 8
FWCI
1.01
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1345 d)
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
Keywords
bovine milk proteins, lymphocyte proliferation, peripheral blood lymphocytes, beta-casomorphin-7, protein synthesis, immunopotentiators, oral bioavailability, immunomodulation
MeSH terms
Amino Acid Sequence, Bromodeoxyuridine, Caseins, Cell Division, Concanavalin A, Dipeptides, DNA, Endorphins, Humans, Leucine, Lymphocyte Activation, Lymphocytes, Milk Proteins, Molecular Sequence Data, Oligopeptides, Peptide Fragments

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