Cited by 203Protein Hydrolysis and Bioactive PeptidesNeuropeptides and Animal PhysiologyChemical Synthesis and Analysis

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Stimulation of human peripheral blood lymphocytes by bioactive peptides derived from bovine milk proteins.

Kayser, Holger, Meisel, Hans·1996·FEBS Letters

Open this paper in CoChat — free account

Abstract

The in vitro modulation of the proliferation of human peripheral blood lymphocytes of different synthetic peptides derived from milk proteins was investigated. Therefore, proliferation changes were followed up after incorporation of BrdU into the DNA, and the influence on protein biosynthesis was measured using the [3 H]leucine incorporation test. Tyr‐Gly and Tyr‐Gly‐Gly significantly enhanced (maximal 90 and 35%, respectively) the proliferation of PBL. For β‐casomorphin‐7 and β‐casokinin‐10, lymphocyte proliferation was suppressed at lower concentrations, but stimulated at higher concentrations (≥10−7 mol/l). Protein synthesis was stimulated (maxima at 25%) only with Tyr‐Gly and Tyr‐Gly‐Gly. The findings point to a need for further studies on the possible function of peptides derived from milk proteins as orally bioavailable immunopotentiatory compounds.

Integrity signals

Registry

Crossref · 10.1016/0014-5793(96)00207-4

Cites

13 of 13 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Manual of clinical immunology
Rose, N. R., & Friedman, H. P. (1976) · Medical Entomology and Zoology · Cited by 718
Separation of Blood Leucocytes, Granulocytes and Lymphocytes
Bøyum, A. (1974) · Tissue Antigens · doi:10.1111/j.1399-0039.1974.tb00252.x · Cited by 670
Suggestive Evidence for Receptors for Morphine and Methionine-Enkephalin on Normal Human Blood T Lymphocytes
Wybran, J., Appelboom, T., Famaey, J.-P., & Govaerts, A. (1979) · The Journal of Immunology · doi:10.4049/jimmunol.123.3.1068 · Cited by 580
Manual of clinical immunology
Virella, G., & Fudenberg, H. H. (1977) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(77)90079-4 · Cited by 469
Bioactive peptides derived from milk proteins. Structural, physiological and analytical aspects
Schlimme, E., & Meisel, H. (1995) · Food / Nahrung · doi:10.1002/food.19950390102 · Cited by 224
Self-citation
Immunostimulating hexapeptide from human casein: amino acid sequence, synthesis and biological properties
Parker, F., Migliore-Samour, D., Floc’h, F., Zerial, A., Werner, G. H., Jollès, P., Casaretto, M., Zahn, H., & Jollès, P. (1984) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1984.tb08609.x · Cited by 176
Casein, a prohormone with an immunomodulating role for the newborn?
Migliore-Samour, D., & Jollès, P. (1988) · Cellular and Molecular Life Sciences · doi:10.1007/bf01941703 · Cited by 145
Neuroimmunomodulation with enkephalins: Enhancement of human natural killer (NK) cell activity in vitro
Faith, R. E., Liang, H. J., Murgo, A. J., & Plotnikoff, N. P. (1984) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(84)90093-x · Cited by 136
New Perspectives in Infant Nutrition
Heird, W. C. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.1.123-a · Cited by 102
β-casomorphins and related peptides: Recent developments
Folkers, G. (1994) · Pharmaceutica Acta Helvetiae · doi:10.1016/0031-6865(94)90034-5 · Cited by 66

Show all 13 references

Research works printed but not linked: 4

Teschemacher H., 1994, β-Casomorphins and Related Peptides: Recent Developments, 3
Meisel H., 1993, Food Proteins — Structure Functionality, 67
Tzehoval E., 1978, Proc. Natl. Acad. Sci. USA, 3400
Paegelow I., 1986, Methods Find. Exp. Clin Pharmacol., 8, 91

Sorted by citations

Bioactive milk peptides: a prospectus.
Clare, D. A., & Swaisgood, H. E. (2000) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(00)74983-6 · Cited by 718
Bioactive Peptides: Synthesis, Sources, Applications, and Proposed Mechanisms of Action
Akbarian, M., Khani, A., Eghbalpour, S., & Uversky, V. N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031445 · Cited by 639
Lactic acid bacteria contribution to gut microbiota complexity: lights and shadows.
Pessione, E. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00086 · Cited by 592
Bioactive peptides and proteins from foods: indication for health effects.
Möller, N. P., Scholz-Ahrens, K. E., Roos, N., & Schrezenmeir, J. (2008) · European Journal of Nutrition · doi:10.1007/s00394-008-0710-2 · Cited by 595
Angiotensin I–converting enzyme inhibitory peptides derived from food proteins and their physiological and pharmacological effects
Li, G., Le, G., Shi, Y., & Shrestha, S. (2004) · Nutrition Research · doi:10.1016/j.nutres.2003.10.014 · Cited by 562
Caseins as source of bioactive peptides
Silva, S. V., & Malcata, F. X. (2004) · International Dairy Journal · doi:10.1016/j.idairyj.2004.04.009 · Cited by 451
Invited review: Physiological properties of bioactive peptides obtained from whey proteins
Madureira, A. R., Tavares, T. G., Gomes, A., Pintado, M., & Malcata, F. X. (2010) · Journal of Dairy Science · doi:10.3168/jds.2009-2566 · Cited by 358
Casein-derived bioactive peptides: Biological effects, industrial uses, safety aspects and regulatory status
Phelan, M., Aherne, A., Fitzgerald, R. J., & O’Brien, N. M. (2009) · International Dairy Journal · doi:10.1016/j.idairyj.2009.06.001 · Cited by 365
Latent Bioactive peptides in milk proteins: proteolytic activation and significance in dairy processing.
Gobbetti, M., Stepaniak, L., De Angelis, M., Corsetti, A., & Di Cagno, R. (2002) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690290825538 · Cited by 344
Bioactive Molecules Released in Food by Lactic Acid Bacteria: Encrypted Peptides and Biogenic Amines
Pessione, E., & Cirrincione, S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00876 · Cited by 333
Food‐Originating ACE Inhibitors, Including Antihypertensive Peptides, as Preventive Food Components in Blood Pressure Reduction
Iwaniak, A., Mińkiewicz, P., & Darewicz, M. (2014) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12051 · Cited by 324
Emerging Health Properties of Whey Proteins and Their Clinical Implications
Krissansen, G. W. (2007) · Journal of the American College of Nutrition · doi:10.1080/07315724.2007.10719652 · Cited by 315
Sequential release of milk protein–derived bioactive peptides in the jejunum in healthy humans
Boutrou, R., Gaudichon, C., Dupont, D., Jardin, J., Airinei, G., Marsset‐Baglieri, A., Benamouzig, R., Tomé, D., & Léonil, J. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.055202 · Cited by 319
Multifunctional peptides encrypted in milk proteins
Meisel, H. (2004) · BioFactors · doi:10.1002/biof.552210111 · Cited by 293
Self-citation
Bioactive peptides derived from milk proteins and their health beneficial potentials: an update
Nagpal, R., Behare, P. V., Rana, R., Kumar, A., Kumar, M., Arora, S., Morotta, F., Jain, S., & Yadav, H. (2010) · Food & Function · doi:10.1039/c0fo00016g · Cited by 297
Bioactive peptides encrypted in milk proteins: proteolytic activation and thropho-functional properties.
Meisel, H., & Bockelmann, W. (1999) · Antonie van Leeuwenhoek · doi:10.1023/a:1002063805780 · Cited by 284
Self-citation
Bioactive Peptides in Amaranth ( Amaranthus hypochondriacus ) Seed
Silva-Sánchez, C., de la Rosa, A. P. B., León‐Galván, M. F., de Lumen, B. O., León‐Rodríguez, A. D., & de Mejı́a, E. G. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf072911z · Cited by 278
Angiotensin I-converting-enzyme-inhibitory and antimicrobial bioactive peptides.
Gobbetti, M., Minervini, F., & Rizzello, C. G. (2004) · International Journal of Dairy Technology · doi:10.1111/j.1471-0307.2004.00139.x · Cited by 268
Immunomodulatory peptides obtained by the enzymatic hydrolysis of whey proteins
Gauthier, S. F., Pouliot, Y., & Saint-Sauveur, D. (2006) · International Dairy Journal · doi:10.1016/j.idairyj.2006.06.014 · Cited by 260
Milk‐derived bioactive peptides and their health promoting effects: a potential role in atherosclerosis
Marcone, S., Belton, O., & Fitzgerald, D. J. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13002 · Cited by 235
Immunoregulatory peptides in bovine milk
Gill, H. S., Doull, F., Rutherfurd, K. J., & Cross, M. L. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500002336 · Cited by 231
Effects of milk containing only A2 beta casein versus milk containing both A1 and A2 beta casein proteins on gastrointestinal physiology, symptoms of discomfort, and cognitive behavior of people with self-reported intolerance to traditional cows’ milk
Jianqin, S., Xu, L., Xia, L., Yelland, G. W., Ni, J., & Clarke, A. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0147-z · Cited by 230
Bioactive peptides and proteins
Pihlanto, A., & Korhonen, H. T. (2003) · Advances in food and nutrition research · doi:10.1016/s1043-4526(03)47004-6 · Cited by 221
Recent advances in food biopeptides: Production, biological functionalities and therapeutic applications
Saâdi, S., Saari, N., Anwar, F., Hamid, A. A., & Ghazali, H. M. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2014.12.003 · Cited by 223
Immunomodulating Effects of Peptidic Fractions Issued from Milk Fermented with Lactobacillus helveticus
LeBlanc, J. G., Matar, C., Valdéz, J. C., LeBlanc, J., & Perdigon, G. (2002) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(02)74360-9 · Cited by 210
Opioid peptides derived from hemoglobin: Hemorphins
Zhao, Q., Garreau-Balandier, I., Sannier, F., & Piot, J. (1997) · Biopolymers · doi:10.1002/(sici)1097-0282(1997)43:2 · Cited by 104
Self-citation
Bioactive peptides in plant-derived foodstuffs
Maestri, E., Marmiroli, M., & Marmiroli, N. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2016.03.048 · Cited by 197
Milk Intolerance, Beta-Casein and Lactose
Pal, S., Woodford, K. B., Kukuljan, S., & Ho, S. S. (2015) · Nutrients · doi:10.3390/nu7095339 · Cited by 186
Biochemical properties of bioactive peptides derived from milk proteins: Potential nutraceuticals for food and pharmaceutical applications
Meisel, H. (1997) · Livestock Production Science · doi:10.1016/s0301-6226(97)00083-3 · Cited by 186
Self-citation
Identification of Bioactive Peptides from Cereal Storage Proteins and Their Potential Role in Prevention of Chronic Diseases
Cavazos, A., & de Mejı́a, E. G. (2013) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12017 · Cited by 177
Alpha‐Lactalbumin: Its Production Technologies and Bioactive Peptides
Kamau, S. M., Cheison, S. C., Chen, W., Liu, X., & Lu, R. (2010) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2009.00100.x · Cited by 169
Casein Fermentate of Lactobacillus animalis DPC6134 Contains a Range of Novel Propeptide Angiotensin-Converting Enzyme Inhibitors
Hayes, M., Stanton, C., Slattery, H., O’Sullivan, Ó., Hill, C., Fitzgerald, G. F., & Ross, R. P. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00096-07 · Cited by 158
Immunomodulating effects of whey proteins and their enzymatic digests.
Mercier, A., Gauthier, S. F., & Fliss, I. (2004) · International Dairy Journal · doi:10.1016/j.idairyj.2003.08.003 · Cited by 147
Farm animal milk proteomics
Roncada, P., Piras, C., Soggiù, A., Turk, R., Urbani, A., & Bonizzi, L. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.05.028 · Cited by 146
Comparative effects of A1 versus A2 beta-casein on gastrointestinal measures: a blinded randomised cross-over pilot study
Ho, S. S., Woodford, K. B., Kukuljan, S., & Pal, S. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2014.127 · Cited by 140
Milk Protein Hydrolysates and Bioactive Peptides
Nongonierma, A. B., O’Keeffe, M. B., & Fitzgerald, R. J. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2800-2_15 · Cited by 142
Bioactive peptides: a review
Besharati, M., & Lackner, M. K. (2023) · The EuroBiotech Journal · doi:10.2478/ebtj-2023-0013 · Cited by 125
Synthesis and application of dipeptides; current status and perspectives
Yagasaki, M., & Hashimoto, S. (2008) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-008-1590-3 · Cited by 125
Bioactive milk peptides: an updated comprehensive overview and database
Nielsen, S. D.-H., Liang, N., Rathish, H., Kim, B. J., Lueangsakulthai, J., Koh, J., Qu, Y., Schulz, H., & Dallas, D. C. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2240396 · Cited by 128
Purification of angiotensin I-converting enzyme inhibitory peptides and antihypertensive effect of milk produced by protease-facilitated lactic fermentation
Chen, G., Tsai, J., & Pan, B. S. (2006) · International Dairy Journal · doi:10.1016/j.idairyj.2006.07.004 · Cited by 121
Identification of Bioactive Peptide Sequences from Amaranth ( Amaranthus hypochondriacus ) Seed Proteins and Their Potential Role in the Prevention of Chronic Diseases
Montoya‐Rodríguez, A., Gómez-Favela, M. A., Reyes‐Moreno, C., Milán‐Carrillo, J., & de Mejı́a, E. G. (2015) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12125 · Cited by 117
Tracking the in vivo release of bioactive peptides in the gut during digestion: Mass spectrometry peptidomic characterization of effluents collected in the gut of dairy matrix fed mini-pigs
Barbé, F., Feunteun, S. L., Rémond, D., Ménard, O., Jardin, J., Henry, G., Laroche, B., & Dupont, D. (2014) · Food Research International · doi:10.1016/j.foodres.2014.02.015 · Cited by 113
Milk Protein Hydrolysates and Bioactive Peptides
Fitzgerald, R. J., & Meisel, H. (2003) · Springer eBooks · doi:10.1007/978-1-4419-8602-3_20 · Cited by 113
Self-citation
Biology and origin of bioactive peptides in milk
Schanbacher, F. L., Talhouk, R., & Murray, F. A. (1997) · Livestock Production Science · doi:10.1016/s0301-6226(97)00082-1 · Cited by 106
Nutritional and Physiological Criteria in the Assessment of Milk Protein Quality for Humans
Bos, C., Gaudichon, C., & Tomé, D. (2000) · Journal of the American College of Nutrition · doi:10.1080/07315724.2000.10718068 · Cited by 104
In vivo digestion of infant formula in piglets: protein digestion kinetics and release of bioactive peptides
Bouzerzour, K., Morgan, F., Cuinet, I., Bonhomme, C., Jardin, J., Huërou‐Luron, I. L., & Dupont, D. (2012) · British Journal Of Nutrition · doi:10.1017/s000711451200027x · Cited by 105
A Peptide Derived from Bovine β-Casein Modulates Functional Properties of Bone Marrow-Derived Macrophages from Germfree and Human Flora-Associated Mice
Sandré, C., Gleizes, A., Forestier, F., Gorges, R., Chilmonczyk, S., Léonil, J., Moreau, M.-C., & Labarre, C. (2001) · Journal of Nutrition · doi:10.1093/jn/131.11.2936 · Cited by 97
Contents of agonistic and antagonistic opioid peptides in different cheese varieties
Sienkiewicz‐Szłapka, E., Jarmołowska, B., Krawczuk, S., Kostyra, E., Kostyra, H., & Iwan, M. (2008) · International Dairy Journal · doi:10.1016/j.idairyj.2008.10.011 · Cited by 84
Proliferative effects of synthetic peptides from β-lactoglobulin and α-lactalbumin on murine splenocytes
Jacquot, A., Gauthier, S. F., Drouin, R., & Boutin, Y. (2010) · International Dairy Journal · doi:10.1016/j.idairyj.2010.02.013 · Cited by 84
Characterization of casein-derived peptide bioactivity: Differential effects on angiotensin-converting enzyme inhibition and cytokine and nitric oxide production
Adams, C., Sawh, F., Green-Johnson, J. M., Jones-Taggart, H., & Strap, J. L. (2020) · Journal of Dairy Science · doi:10.3168/jds.2019-17976 · Cited by 85
Review of the potential health impact of β-casomorphins and related peptides
(EFSA), E. F. S. A. (2009) · EFSA Journal · doi:10.2903/j.efsa.2009.231r · Cited by 94
Food‐derived immunomodulatory peptides
Santiago‐López, L., Hernández‐Mendoza, A., Vallejo‐Córdoba, B., Mata‐Haro, V., & González-Córdova, A. F. (2016) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.7697 · Cited by 83
Potential bioactive effects of casein hydrolysates on human cultured cells
Phelan, M., Aherne-Bruce, S. A., O’Sullivan, D., Fitzgerald, R. J., & O’Brien, N. M. (2009) · International Dairy Journal · doi:10.1016/j.idairyj.2008.12.004 · Cited by 80
Effect of chickpea protein hydrolysates on cell proliferation and in vitro bioavailability
Girón‐Calle, J., Alaiz, M., & Vioque, J. (2010) · Food Research International · doi:10.1016/j.foodres.2010.03.020 · Cited by 80
Release of angiotensin converting enzyme-inhibitory peptides by simulated gastrointestinal digestion of infant formulas
Hernández‐Ledesma, B., Amigo, L., Ramos, M., & Recio, I. (2004) · International Dairy Journal · doi:10.1016/j.idairyj.2004.02.011 · Cited by 79
Bioactive peptides in dairy products
Tidona, F., Criscione, A., Guastella, A. M., Zuccaro, A., Bordonaro, S., & Marletta, D. (2009) · Italian Journal of Animal Science · doi:10.4081/ijas.2009.315 · Cited by 77
Peptidomic Profile of Milk of Holstein Cows at Peak Lactation
Dallas, D. C., Guerrero, A., Parker, E. A., Garay, L. A., Bhandari, A., Lebrilla, C. B., Barile, D., & German, J. B. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4040964 · Cited by 64
In Silico and In Vitro Analysis of Multifunctionality of Animal Food-Derived Peptides
Amigo, L., Martínez‐Maqueda, D., & Hernández‐Ledesma, B. (2020) · Foods · doi:10.3390/foods9080991 · Cited by 64
Differences in the peptide profile of raw and pasteurised ovine milk cheese and implications for its bioactive potential
Pisanu, S., Pagnozzi, D., Pes, M., Pirisi, A., Roggio, T., Uzzau, S., & Addis, M. F. (2014) · International Dairy Journal · doi:10.1016/j.idairyj.2014.10.007 · Cited by 63
Discovery and quantification of bioactive peptides in fermented cucumber by direct analysis IR-MALDESI mass spectrometry and LC-QQQ-MS
Moore, J. F., Johanningsmeier, S. D., Ekelöf, M., & Muddiman, D. C. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.07.187 · Cited by 64
Cheese as Functional Food: The Example of Parmigiano Reggiano and Grana Padano
Summer, A., Formaggioni, P., Franceschi, P., Frangia, F. D., Righi, F., & Malacarne, M. (2017) · Food Technology and Biotechnology · doi:10.17113/ftb.55.03.17.5233 · Cited by 63
Milk Fermented by Specific Lactobacillus Strains Regulates the Serum Levels of IL-6, TNF-α and IL-10 Cytokines in a LPS-Stimulated Murine Model
Reyes‐Díaz, A., Mata‐Haro, V., Hernández, J., González-Córdova, A. F., Hernández‐Mendoza, A., Reyes‐Díaz, R., Torres‐Llanez, M. J., Beltrán‐Barrientos, L. M., & Vallejo‐Córdoba, B. (2018) · Nutrients · doi:10.3390/nu10060691 · Cited by 62
Bioactive peptide production by hydrolysis of porcine blood proteins in a continuous enzymatic membrane reactor
Wei, J., & Chiang, B. (2008) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.3451 · Cited by 59
The Immunoenhancing Property of a Dietary Casein Phosphopeptide Preparation in Mice
Otani, H., Kihara, Y., & Park, M. (2000) · Food and Agricultural Immunology · doi:10.1080/095401000404102 · Cited by 58
Opioid peptides derived from milk proteins
Kostyra, E., Sienkiewicz‐Szłapka, E., Jarmołowska, B., Krawczuk, S., & Kostyra, H. (2004) · Polish Journal of Food and Nutrition Sciences · Cited by 57
Bioactive Components in Goat Milk
Park, Y. W. (2009) · Wiley eBooks · doi:10.1002/9780813821504.ch3 · Cited by 59
Chickpea protein hydrolysate as a substitute for serum in cell culture
Girón‐Calle, J., Vioque, J., Pedroche, J., Alaiz, M., Yust, M. D. M., Megías, C., & Millán, F. (2008) · Cytotechnology · doi:10.1007/s10616-008-9170-z · Cited by 54
Implications of the Maillard reaction on bovine alpha-lactalbumin and its proteolysis during in vitro infant digestion
Joubran, Y., Moscovici, A., Portmann, R., & Lesmes, U. (2017) · Food & Function · doi:10.1039/c7fo00588a · Cited by 54
Buffalo Milk Casein Derived Decapeptide (YQEPVLGPVR) Having Bifunctional Anti-inflammatory and Antioxidative Features Under Cellular Milieu
Sowmya, K., Bhat, M. I., Bajaj, R. K., Kapila, S., & Kapila, R. (2018) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-018-9708-7 · Cited by 53
Functional Properties of Bioactive Peptides Derived From Meat Proteins
Arihara, K. (2006) · Food science and technology · doi:10.1201/9781420017311.ch10 · Cited by 51
Immunomodulation by hydrolysates and peptides derived from milk proteins
Reyes‐Díaz, A., González-Córdova, A. F., Hernández‐Mendoza, A., Reyes‐Díaz, R., & Vallejo‐Córdoba, B. (2017) · International Journal of Dairy Technology · doi:10.1111/1471-0307.12421 · Cited by 50
Casein and Peptides Derived from Casein as Antileukaemic Agents
Ledesma-Martínez, E., Aguíñiga-Sánchez, I., Weiss‐Steider, B., Rivera-Martínez, A. R., & Santiago‐Osorio, E. (2019) · Journal of Oncology · doi:10.1155/2019/8150967 · Cited by 48
Serum activity of dipeptidyl peptidase IV (DPPIV; EC 3.4.14.5) in breast-fed infants with symptoms of allergy
Jarmołowska, B., Bielikowicz, K., Iwan, M., Sidor, K., Kostyra, E., & Kaczmarski, M. G. (2007) · Peptides · doi:10.1016/j.peptides.2006.11.014 · Cited by 47
Milk Bioactive Peptides: Antioxidant, Antimicrobial and Anti-Diabetic Activities
El-Sayed, M. I., & Awad, S. (2019) · Advances in Biochemistry · doi:10.11648/j.ab.20190701.15 · Cited by 43
In vivo digestomics of milk proteins in human milk and infant formula using a suckling rat pup model
Wada, Y., Phinney, B. S., Weber, D., & Lönnerdal, B. L. (2016) · Peptides · doi:10.1016/j.peptides.2016.11.012 · Cited by 40
Effect of milk proteins and their hydrolysates on in vitro immune responses
Eriksen, E. K., Vegarud, G. E., Langsrud, T., Almaas, H., & Lea, T. (2008) · Small Ruminant Research · doi:10.1016/j.smallrumres.2008.07.003 · Cited by 40
Extensively hydrolyzed casein formula alone or with L. rhamnosus GG reduces β‐lactoglobulin sensitization in mice
Aitoro, R., Simeoli, R., Amoroso, A., Paparo, L., Nocerino, R., Pirozzi, C., Costanzo, M. D., Meli, R., Caro, C. D., Picariello, G., et al. (2016) · Pediatric Allergy and Immunology · doi:10.1111/pai.12687 · Cited by 39
Expression of Milk-Derived Antihypertensive Peptide in Escherichia coli
Lv, G. S., Huo, G., & Fu, X. (2003) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(03)73779-5 · Cited by 38
Nanocarrier possibilities for functional targeting of bioactive peptides and proteins:state-of-the-art
Moutinho, C. M. S. G., Matos, C. M., Teixeira, J. A., & Balcão, V. M. (2011) · Journal of drug targeting · doi:10.3109/1061186x.2011.628397 · Cited by 39
Whey proteins and peptides: beneficial effects on immune health
Beaulieu, J., Dupont, C., & Lemieux, P. (2006) · Therapy · doi:10.2217/14750708.3.1.69 · Cited by 38
Functional Properties of Bioactive Peptides Derived From Meat Proteins
Nollet, L. M. L., & Toldra, F. (2006) · CRC Press eBooks · doi:10.1201/9781420017311-14 · Cited by 37
Fish and Shellfish Upgrading, Traceability
Guérard, F., Sellos, D., & Gal, Y. L. (2005) · Advances in biochemical engineering, biotechnology · doi:10.1007/b135783 · Cited by 39
Beneficial Effects of Vitamins, Minerals, and Bioactive Peptides on Strengthening the Immune System Against COVID-19 and the Role of Cow’s Milk in the Supply of These Nutrients
Ahvanooei, M. R. R., Norouzian, M. A., & Vahmani, P. (2021) · Biological Trace Element Research · doi:10.1007/s12011-021-03045-x · Cited by 36
Milk proteins
O’Regan, J. B., Ennis, M. P., & Mulvihill, D. M. (2009) · Elsevier eBooks · doi:10.1533/9781845695873.298 · Cited by 41
The influence of μ-opioid receptor agonist and antagonist peptides on peripheral blood mononuclear cells (PBMCs)
Fiedorowicz, E., Jarmołowska, B., Iwan, M., Kostyra, E., Obuchowicz, R., & Obuchowicz, M. (2010) · Peptides · doi:10.1016/j.peptides.2010.12.003 · Cited by 35
Whey proteins and peptides
Pihlanto, A. (2011) · Nutrafoods · doi:10.1007/bf03223386 · Cited by 35
Apoptosis induced by modified ribonucleosides in human cell culture systems
Meisel, H., Günther, S., Martin, D., & Schlimme, E. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00927-2 · Cited by 35
Self-citation
Green seaweed Ulva lactuca, a potential source of bioactive peptides revealed by in silico analysis
Amin, M. A., Chondra, U., Mostafa, E., & Alam, M. M. (2022) · Informatics in Medicine Unlocked · doi:10.1016/j.imu.2022.101099 · Cited by 33
Milk-derived anti-infectives and their potential to combat bacterial and viral infection
Morrin, S. T., Buck, R. H., Farrow, M., & Hickey, R. M. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104442 · Cited by 34
Bio-accessible milk casein derived tripeptide (LLY) mediates overlapping anti- inflammatory and anti-oxidative effects under cellular (Caco-2) and in vivo milieu
Sowmya, K., Mala, D., Bhat, M. I., Kumar, N., Bajaj, R. K., Kapila, S., & Kapila, R. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.09.002 · Cited by 32
Type 1 diabetes, the A1 milk hypothesis and vitamin D deficiency
Merriman, T. R. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.11.010 · Cited by 32
Peptidomic and glycomic profiling of commercial dairy products: identification, quantification and potential bioactivities
Bhattacharya, M., Salcedo, J., Robinson, R. C., Henrick, B. M., & Barile, D. (2019) · npj Science of Food · doi:10.1038/s41538-019-0037-9 · Cited by 30
Role of milk glycome in prevention, treatment, and recovery of COVID-19
Kaplan, M., Şahutoğlu, A. S., Sarıtaş, S., Duman, H., Arslan, A., Pekdemir, B., & Karav, S. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1033779 · Cited by 31
Composition and properties of peptides that survive standardised in vitro gastro-pancreatic digestion of bovine milk
Tagliazucchi, D., Helal, A., Verzelloni, E., Bellesia, A., & Conte, A. (2016) · International Dairy Journal · doi:10.1016/j.idairyj.2016.06.002 · Cited by 29
Extent of hydrolysis effects on casein hydrolysate bioactivity: Evaluation using the human Jurkat T cell line
Lahart, N., O’Callaghan, Y. C., Aherne, S. A., O’Sullivan, D., Fitzgerald, R. J., & O’Brien, N. M. (2011) · International Dairy Journal · doi:10.1016/j.idairyj.2011.03.014 · Cited by 29
Through the eye of an electrospray needle: mass spectrometric identification of the major peptides and proteins in the milk of the one‐humped camel (Camelus dromedarius)
Alhaider, A. A., Gader, A. G. M. A., Turjoman, A. A., Newell, K., Hunsucker, S. W., Shan, B., Ma, B., Gibson, D. S., & Duncan, M. W. (2013) · Journal of Mass Spectrometry · doi:10.1002/jms.3213 · Cited by 29
Bioactive peptides encrypted in milk proteins: proteolytic activation and thropho-functional properties
Meisel, H., & Bockelmann, W. (1999) · Springer eBooks · doi:10.1007/978-94-017-2027-4_10 · Cited by 29
Self-citation
Exploring Potential Bioactive Peptides in Fermented Bactrian Camel’s Milk and Mare’s Milk Made by Mongolian Nomads
Ganzorig, K., Urashima, T., & Fukuda, K. (2020) · Foods · doi:10.3390/foods9121817 · Cited by 29
Peptides Derived from In Vitro and In Vivo Digestion of Human Milk Are Immunomodulatory in THP-1 Human Macrophages
Liang, N., Beverly, R. L., Scottoline, B. P., & Dallas, D. C. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab350 · Cited by 26
Antioxidative and anti-inflammatory potential with trans-epithelial transport of a buffalo casein-derived hexapeptide (YFYPQL)
Sowmya, K., Bhat, M. I., Bajaj, R. K., Kapila, S., & Kapila, R. (2019) · Food Bioscience · doi:10.1016/j.fbio.2019.02.003 · Cited by 26

Authors: Kayser, H., & Meisel, H.
Affiliations: Christian-Albrechts-Universität zu Kiel (DE)
Venue: FEBS Letters
Publisher: Wiley
Published: 1996-03-25
Volume: 383
Issue: 1-2
Pages: 18-20
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/0014-5793(96)00207-4
OpenAlex: W1999372506
Cited by: 203
References: 13
Citations by year: 2026: 5 · 2025: 5 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 9 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 11 · 2015: 5 · 2014: 11 · 2013: 9 · 2012: 8
FWCI: 1.01
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1345 d)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
Keywords: bovine milk proteins, lymphocyte proliferation, peripheral blood lymphocytes, beta-casomorphin-7, protein synthesis, immunopotentiators, oral bioavailability, immunomodulation
MeSH terms: Amino Acid Sequence, Bromodeoxyuridine, Caseins, Cell Division, Concanavalin A, Dipeptides, DNA, Endorphins, Humans, Leucine, Lymphocyte Activation, Lymphocytes, Milk Proteins, Molecular Sequence Data, Oligopeptides, Peptide Fragments

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Stimulation of human peripheral blood lymphocytes by bioactive peptides derived from bovine milk proteins.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks