The DOI matches its Crossref record.
Cell adhesion and integrin binding to recombinant human fibrillin‐1
Abstract
Fibrillin‐1 is a major constituent of tissue microfibrils that occur in most connective tissues, either in close association with or independent of elastin. To test possible cell‐adhesive functions of this protein, we used recombinant human fibrillin‐1 polypeptides produced in a mammalian expression system in cell attachment and solid‐phase integrin binding assays. Fibrillin‐1 polypeptides containing the single RGD sequence located in the fourth 8‐cysteine domain, mediated distinct cell adhesion of a variety of cell lines and bound to purified integrin αVβ3. Integrins αIIbβ3, α5β1, α2β1 and α1β1 did not interact with any of the recombinant fibrillin‐1 peptides. Our results indicate a novel role for fibrillin‐1 in cellular interactions mediated via an RGD motif that is appropriately exposed for recognition by integrin αVβ3.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
New insights into elastic fiber assembly
Wagenseil, J. E., & Mecham, R. P. (2007) · Birth Defects Research Part C: Embryo Today: Reviews · doi:10.1002/bdrc.20111 · Cited by 420
Vascular wall extracellular matrix proteins and vascular diseases
Xu, J., & Shi, G.-P. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.07.008 · Cited by 381
Review Article: A new wrinkle on old skin: the role of elastic fibres in skin ageing
Langton, A. K., Sherratt, M. J., Griffiths, C. E. M., & Watson, R. E. B. (2010) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2010.00574.x · Cited by 177
Metadata
- Authors
- Pfaff, M., Reinhardt, D. P., Sakai, L. Y., & Timpl, R.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1996-04-22
- Volume
- 384
- Issue
- 3
- Pages
- 247-250
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2040589687
- Cited by
- 169
- References
- 0
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cell adhesion and integrin binding to recombinant human fibrillin‐1. https://app.cochat.ai/papers/10.1016/0014-5793(96)00325-0
- The paper
- Pfaff, M., Reinhardt, D. P., Sakai, L. Y., & Timpl, R. (1996). Cell adhesion and integrin binding to recombinant human fibrillin‐1. FEBS Letters. https://doi.org/10.1016/0014-5793(96)00325-0
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
