Review Article: A new wrinkle on old skin: the role of elastic fibres in skin ageing

Langton, A. K.; Sherratt, M. J.; Griffiths, C. E. M.; Watson, R. E. B.

doi:10.1111/j.1468-2494.2010.00574.x

Cited by 177Skin Protection and AgingConnective tissue disorders researchFacial Rejuvenation and Surgery Techniques

Review Article: A new wrinkle on old skin: the role of elastic fibres in skin ageing

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Langton, A. K., Sherratt, M. J., Griffiths, C. E. M., Watson, R. E. B.·2010·International Journal of Cosmetic Science

DOI 10.1111/j.1468-2494.2010.00574.x

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Abstract

Synopsis: Cutaneous ageing is the result of two distinct, biological processes which may occur concurrently: (i) the passage of time, termed intrinsic ageing and (ii) environmental influences, termed extrinsic ageing. Intrinsic ageing of the skin is a slow process which causes changes in tissue structure and impairs function in the absence of additional biological, chemical and physical factors. The clinical features of intrinsically aged skin are not usually evident until old age when, although smooth and unblemished, the skin surface appears pale and is characterized by fine wrinkles with occasional exaggerated expression lines. Functionally, intrinsically aged skin is dry and less elastic than more youthful skin. In contrast, extrinsically aged skin is exemplified by deep, coarse wrinkles, mottled hyperpigmentation and a marked loss of elasticity and recoil. The two major environmental influences which induce extrinsic ageing are: (i) chronic exposure to solar ultraviolet (UV) irradiation (termed photoageing) and (ii) smoking. This review discusses the changes associated with the ageing process in the skin, with particular emphasis on the role played by the elastic fibre network in maintaining dermal function. The review concludes with a discussion of a short‐term assay for independent assessment of the efficacy of anti‐ageing cosmetic products using the elastic fibre component fibrillin‐1 as a biomarker of extracellular matrix repair.

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Crossref · 10.1111/j.1468-2494.2010.00574.x

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Skin ageing occurs inevitably as a consequence of physiological changes over time due to genetic factors and changes in cell metabolism and tissue structure.
“According to Farage et al. [12], skin ageing occurs inevitably as a consequence of physiological changes over time due to genetic factors and changes in cell metabolism and the tissue structure [13 -16].”
From Elastin structure and its involvement in skin photoageing (2017) · cites this paper as [14]
The Synopsis describes intrinsic skin ageing as a process associated with the passage of time that changes tissue structure and impairs function; the section “Characteristic features of intrinsically aged skin” gives examples of structural and cellular changes. These passages do not identify genetic factors or changes in cell metabolism as causes. Page numbers are unavailable in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Components such as fibrillins, fibulins, MAGPs (mainly MAGP1 and MAGP2), and proteoglycans form a scaffold in which tropoelastin molecules are deposited on preformed bundles of fibrillin microfibrils in the pericellular space.
“Components such as fibrillins, fibulins, microfibril-associated glycoproteins (MAGPs) -mainly MAGP1 and MAGP2, and proteoglycans form a scaffold in which tropoelastin molecules are deposited on preformed bundles of fibrillin microfibrils in the pericellular space [14, 46, 48].”
From Elastin structure and its involvement in skin photoageing (2017) · cites this paper as [14]
The sections on elastin and fibrillin microfibrils describe a microfibrillar scaffold that receives tropoelastin, and say fibrillin microfibrils can assemble independently of tropoelastin near cell surfaces. They also describe an interaction between a microfibril-associated glycoprotein and tropoelastin. Our copy does not identify fibulins, MAGP1 and MAGP2, or proteoglycans as components of that scaffold, or specify that deposition occurs on preformed bundles in the pericellular space. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Acute exposure of skin to UV radiation can cause sunburn, resulting in a large inflammatory response with characteristic redness, swelling and heat.
“Acute exposure of skin to UV radiation can cause sunburn, resulting in a large inflammatory response causing characteristic redness, swelling and heat. In addition, altered pigmentation, immune suppression and damage to the dermal extracellular matrix can occur [24,25,56,142,143].”
From The Roles of Vitamin C in Skin Health. (2017) · cites this paper as [24]
The section “Characteristic features of extrinsically aged skin” states that acute UV exposure causes sunburn and inflammation. It does not describe the response as large or specify redness, swelling, and heat; the mention of erythema elsewhere concerns topical retinoid treatment, not UV exposure. No page number is available in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Delivery of nutrients to the epidermis is dependent on diffusion from the vascularized dermis.
“Delivery of nutrients is dependent on diffusion from the vascularized dermis [24]”
From The Roles of Vitamin C in Skin Health. (2017) · cites this paper as [24]
The epidermis lacks the blood vessels that normally deliver nutrients to cells.
“The epidermis is a challenged environment for nutrient delivery, as it lacks the blood vessels that normally deliver nutrients to cells.”
From The Roles of Vitamin C in Skin Health. (2017) · cites this paper as [24]

Chronic long-term exposure to UV radiation causes premature aging of the skin, with disruption to skin structure, and leads to the development of skin cancer.
“By comparison, chronic long-term exposure to UV radiation causes premature aging of the skin, with dramatic and significant disruption to skin structure, and leads to the development of skin cancer [6,24].”
From The Roles of Vitamin C in Skin Health. (2017) · cites this paper as [24]
Elastic fibres throughout the dermis are susceptible to UV radiation, with accumulation of disorganised elastic fibre proteins in severely photoaged skin.
“Elastic fibres throughout the dermis are also susceptible to UV radiation, with accumulation of disorganised elastic fibre proteins evident in severely photoaged skin. Indeed, this accumulation, termed ‘solar elastosis’, is considered to be a defining characteristic of severely photoaged skin [6,22,24,126].”
From The Roles of Vitamin C in Skin Health. (2017) · cites this paper as [24]
Both epidermal and dermal layers of skin are susceptible to chronic UV exposure, but the most profound changes occur in the extracellular matrix of the dermis.
“Both the epidermal and dermal layers of skin are susceptible to chronic UV exposure; however, the most profound changes occur in the extracellular matrix of the dermis [24].”
From The Roles of Vitamin C in Skin Health. (2017) · cites this paper as [24]
Acute UV exposure can cause altered pigmentation, immune suppression and damage to the dermal extracellular matrix.
“Acute exposure of skin to UV radiation can cause sunburn, resulting in a large inflammatory response causing characteristic redness, swelling and heat. In addition, altered pigmentation, immune suppression and damage to the dermal extracellular matrix can occur [24,25,56,142,143].”
From The Roles of Vitamin C in Skin Health. (2017) · cites this paper as [24]
Solar elastosis is considered a defining characteristic of severely photoaged skin.
“Elastic fibres throughout the dermis are also susceptible to UV radiation, with accumulation of disorganised elastic fibre proteins evident in severely photoaged skin. Indeed, this accumulation, termed ‘solar elastosis’, is considered to be a defining characteristic of severely photoaged skin [6,22,24,126].”
From The Roles of Vitamin C in Skin Health. (2017) · cites this paper as [24]

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Matrix Metalloproteinases: A Review
Birkedal‐Hansen, H., Moore, W. G. I., Bodden, M., Windsor, L. J., BIRKEDAL‐HANSEN, B., DeCarlo, A. A., & Engler, J. A. (1993) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411930040020401 · Cited by 2,957 · see citing works
Pathophysiology of Premature Skin Aging Induced by Ultraviolet Light
Fisher, G. J., Wang, Z., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711133372003 · Cited by 1,501 · see citing works
The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.
Van Wart, H. E., & Birkedal-Hansen, H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5578 · Cited by 1,475 · see citing works
Molecular basis of sun-induced premature skin ageing and retinoid antagonism
Fisher, G. J., Datta, S. C., Talwar, H. S., Wang, Z.-Q., Varani, J., Kang, S., & Voorhees, J. J. (1996) · Nature · doi:10.1038/379335a0 · Cited by 1,410 · see citing works
Elastic fibres
Kielty, C. M., Sherratt, M. J., & Shuttleworth, C. A. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.14.2817 · Cited by 841 · see citing works
Self-citation
Matrix-Degrading Metalloproteinases in Photoaging
Quan, T., Qin, Z., Xia, W., Shao, Y., Voorhees, J. J., & Fisher, G. J. (2009) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/jidsymp.2009.8 · Cited by 740 · see citing works
Vitamin A Antagonizes Decreased Cell Growth and Elevated Collagen-Degrading Matrix Metalloproteinases and Stimulates Collagen Accumulation in Naturally Aged Human Skin1
Varani, J., Warner, R. L., Gharaee-Kermani, M., Phan, S. H., Kang, S., Chung, J., Wang, Z., Datta, S. C., Fisher, G. J., & Voorhees, J. J. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00902.x · Cited by 643 · see citing works
Topical tretinoin for photoaged skin
Kligman, A. M., Grove, G. L., Hirose, R., & Leyden, J. J. (1986) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(86)70242-9 · Cited by 620 · see citing works
Biochemistry of tropoelastin
Vrhovski, B., & Weiss, A. S. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2580001.x · Cited by 544 · see citing works
Structural and functional changes of normal aging skin
Fenske, N. A., & Lober, C. W. (1986) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(86)70208-9 · Cited by 535 · see citing works
Elastin
Mithieux, S. M., & Weiss, A. S. (2005) · Advances in protein chemistry · doi:10.1016/s0065-3233(05)70013-9 · Cited by 511 · see citing works
Topical Tretinoin Improves Photoaged Skin
Weiss, J. (1988) · JAMA · doi:10.1001/jama.1988.03720040019020 · Cited by 490 · see citing works
Photoaging of the skin from phenotype to mechanisms
Scharffetter‐Kochanek, K., Brenneisen, P., Wenk, J., Herrmann, G., Ma, W., Kuhr, L., Meewes, C., & Wlaschek, M. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00098-x · Cited by 487 · see citing works
Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices
Zhang, H., Apfelroth, S., Hu, W., Davis, E., Sanguineti, C., Bonadio, J. F., Mecham, R. P., & Ramirez, F. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.5.855 · Cited by 384 · see citing works
Genomic organization of the sequence coding for fibrillin, the defective gene product in Marfan syndrome
Pereira, L. V., D’Alessio, M., Ramirez, F., Lynch, J. R., Sykes, B. C., Pangilinan, T., & Bonadio, J. F. (1993) · Human Molecular Genetics · doi:10.1093/hmg/2.10.1762 · Cited by 356 · see citing works
Alternative splicing of human elastin mRNA indicated by sequence analysis of cloned genomic and complementary DNA.
Indik, Z., Yeh, H., Ornstein-Goldstein, N., Sheppard, P., Anderson, N., Rosenbloom, J. C., Peltonen, L., & Rosenbloom, J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5680 · Cited by 334 · see citing works
Tissue elasticity and the ageing elastic fibre
Sherratt, M. J. (2009) · AGE · doi:10.1007/s11357-009-9103-6 · Cited by 334 · see citing works
Self-citation
Effects of Aging and Chronic Sun Exposure on Melanocytes in Human Skin
Gilchrest, B. A., Blog, F. B., & Szabo, G. (1979) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12581580 · Cited by 328 · see citing works
Oxytalan, Elaunin, And Elastic Fibers In The Human Skin
Cotta-Pereira, G., Rodrigo, G., & Bittencourt-Sampaio, S. (1976) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12481882 · Cited by 327 · see citing works
Structural Changes in Aging Human Skin
Montagna, W., & Carlisle, K. S. (1979) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12532761 · Cited by 322 · see citing works
Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.
Zhang, H., Hu, W., & Ramirez, F. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.4.1165 · Cited by 317 · see citing works
Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling
Ashworth, J. L., Murphy, G., Rock, M. J., Sherratt, M. J., SHAPIRO, S. D., Shuttleworth, C. A., & Kielty, C. M. (1999) · Biochemical Journal · doi:10.1042/bj3400171 · Cited by 291 · see citing works
Self-citation
Age, sunlight, and facial skin: A histologic and quantitative study
Warren, R., Gartstein, V., Kligman, A. M., Montagna, W., Allendorf, R. A., & Ridder, G. M. (1991) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(08)80964-4 · Cited by 271 · see citing works
Fibrillin-1: Organization in Microfibrils and Structural Properties
Reinhardt, D. P., Keene, D. R., Corson, G. M., Pöschl, E., Bächinger, H. P., Gambee, J. E., & Sakai, L. Y. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0237 · Cited by 253 · see citing works
Cigarette Smoking: Risk Factor for Premature Facial Wrinkling
Kadunce, D. P., Burr, R., Gress, R. E., Kanner, R. E., Lyon, J. L., & Zone, J. J. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-10-840 · Cited by 253 · see citing works
Enhanced Elastin and Fibrillin Gene Expression in Chronically Photodamaged Skin
Chen, Y. Q., Bernstein, E. F., Tamai, K., Shepley, K. J., Resnik, K. S., Zhang, H., Tuan, R. S., Mauviel, A., & Uitto, J. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12392693 · Cited by 234 · see citing works
Biochemistry of the Elastic Fibers in Normal Connective Tissues and its Alterations in Diseases
Uitto, J. (1979) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12530093 · Cited by 220 · see citing works
Ultraviolet A Irradiation Stimulates Collagenase Production in Cultured Human Fibroblasts
Petersen, M. J., Hansen, C. D., & Craig, S. (1992) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12616142 · Cited by 212 · see citing works
Facial wrinkling in men and women, by smoking status.
Ernster, V. L., Grady, D., Miike, R., Black, D., Selby, J. V., & Kerlikowske, K. M. (1995) · American Journal of Public Health · doi:10.2105/ajph.85.1.78 · Cited by 209 · see citing works
Matrix metalloproteinase-1 and skin ageing in smokers
Lahmann, C., Bergemann, J., Harrison, G., & Young, A. R. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04220-3 · Cited by 206 · see citing works
Extraction of extendable beaded structures and their identification as fibrillin-containing extracellular matrix microfibrils.
Keene, D. R., Maddox, B. K., Kuo, H., Sakai, L. Y., & Glanville, R. W. (1991) · Journal of Histochemistry & Cytochemistry · doi:10.1177/39.4.2005373 · Cited by 206 · see citing works
Cell Adhesion to Fibrillin-1 Molecules and Microfibrils Is Mediated by α5β1 and αvβ3 Integrins
Bax, D. V., Bernard, S. E., Lomas, A., McGovern, A., Humphries, J. D., Shuttleworth, C. A., Humphries, M. J., & Kielty, C. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303159200 · Cited by 205 · see citing works
Smoker's Wrinkles
Daniell, H. (1971) · Annals of Internal Medicine · doi:10.7326/0003-4819-75-6-873 · Cited by 198 · see citing works
Histology of sun-damaged human skin
Montagna, W., Kirchner, S. J., & Carlisle, K. S. (1989) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(89)70276-0 · Cited by 193 · see citing works
Cell-type Specific Recognition of RGD- and Non-RGD-containing Cell Binding Domains in Fibrillin-1
Sakamoto, H., Broekelmann, T. J., Cheresh, D. A., Ramirez, F., Rosenbloom, J., & Mecham, R. P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.9.4916 · Cited by 191 · see citing works
An elastin gene mutation producing abnormal tropoelastin and abnormal elastic fibres in a patient with autosomal dominant cutis laxa
Tassabehji, M. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.6.1021 · Cited by 188 · see citing works
Differential expression of fibrillin-3 adds to microfibril variety in human and avian, but not rodent, connective tissues
Corson, G. M., Charbonneau, N. L., Keene, D. R., & Sakai, L. Y. (2003) · Genomics · doi:10.1016/j.ygeno.2003.08.023 · Cited by 185 · see citing works
Fibrillin-Rich Microfibrils are Reduced in Photoaged Skin. Distribution at the Dermal–Epidermal Junction
Watson, R. E. B., Griffiths, C. E. M., Craven, N. M., Shuttleworth, C. A., & Kielty, C. M. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00562.x · Cited by 185 · see citing works
Self-citation
Cellular, Immunologic and Biochemical Characterization of Topical Retinoic Acid—Treated Human Skin
Fisher, G. J., Esmann, J., Grifliths, C. E. M., Talwar, H. S., Duell, E. A., Hammerberg, C., Elder, J. T., Karabin, G. D., Nickoloff, B. J., Cooper, K. D., et al. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12470632 · Cited by 182 · see citing works
Understanding Premature Skin Aging
Uitto, J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711133372011 · Cited by 178 · see citing works
Chronic Solar Dermatosis: A Light and Electron Microscopic Study of the Dermis*
Mitchell, R. E. (1967) · Journal of Investigative Dermatology · doi:10.1038/jid.1967.33 · Cited by 176 · see citing works
Skin aging induced by ultraviolet exposure and tobacco smoking: evidence from epidemiological and molecular studies
Yin, L., Morita, A., & Tsuji, T. (2001) · Photodermatology, Photoimmunology & Photomedicine · doi:10.1034/j.1600-0781.2001.170407.x · Cited by 172 · see citing works
Cell adhesion and integrin binding to recombinant human fibrillin‐1
Pfaff, M., Reinhardt, D. P., Sakai, L. Y., & Timpl, R. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00325-0 · Cited by 169 · see citing works
Homo- and Heterotypic Fibrillin-1 and -2 Interactions Constitute the Basis for the Assembly of Microfibrils
Lin, G., Tiedemann, K., Vollbrandt, T., Peters, H., Bätge, B., Brinckmann, J., & Reinhardt, D. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m210611200 · Cited by 157 · see citing works
Prediction of the Coding Sequences of Unidentified Human Genes. XX. The Complete Sequences of 100 New cDNA Clones from Brain Which Code for Large Proteins in vitro
Nagase, T. (2001) · DNA Research · doi:10.1093/dnares/8.2.85 · Cited by 154 · see citing works
Elastic Fiber Structure and Assembly
Mecham, R. P., & Davis, E. C. (1994) · Elsevier eBooks · doi:10.1016/b978-0-12-775170-2.50014-7 · Cited by 153 · see citing works
Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation. A double-blind, vehicle-controlled comparison of 0.1% and 0.025% tretinoin creams
Griffiths, C. E. M. (1995) · Archives of Dermatology · doi:10.1001/archderm.131.9.1037 · Cited by 152 · see citing works
Self-citation
Smoker's face: an underrated clinical sign?
Model, D. (1985) · BMJ · doi:10.1136/bmj.291.6511.1760 · Cited by 139 · see citing works
Fibrillin mutations in Marfan syndrome and related phenotypes
Ramirez, F. (1996) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(96)80007-4 · Cited by 135 · see citing works
Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights into Microfibril Organization
Lee, S. S. J., Knott, V., Jovanović, J., Harlos, K., Grimes, J. M., Choulier, L., Mardon, H. J., Stuart, D. I., & Handford, P. A. (2004) · Structure · doi:10.1016/j.str.2004.02.023 · Cited by 133 · see citing works
Fibrillin Microfibrils
Kielty, C. M., Sherratt, M. J., Marson, A., & Baldock, C. (2005) · Advances in protein chemistry · doi:10.1016/s0065-3233(05)70012-7 · Cited by 133 · see citing works
Self-citation
Functional domains on elastin and microfibril-associated glycoprotein involved in elastic fibre assembly
Brown‐Augsburger, P., Broekelmann, T. J., Rosenbloom, J., & Mecham, R. P. (1996) · Biochemical Journal · doi:10.1042/bj3180149 · Cited by 128 · see citing works
Isolation and ultrastructural analysis of microfibrillar structures from foetal bovine elastic tissues: Relative abundance and supramolecular architecture of type VI collagen assemblies and fibrillin
Kielty, C. M., Cummings, C., Whittaker, S. P., Shuttleworth, C. A., & Grant, M. E. (1991) · Journal of Cell Science · doi:10.1242/jcs.99.4.797 · Cited by 124 · see citing works
Cigarette smoking associated with premature facial wrinkling: image analysis of facial skin replicas
Koh, J. S., Kang, H., Choi, S. W., & Kim, H. O. (2002) · International Journal of Dermatology · doi:10.1046/j.1365-4362.2002.01352.x · Cited by 121 · see citing works
Fibrillin: from domain structure to supramolecular assembly
Handford, P. A., Downing, A. K., Reinhardt, D. P., & Sakai, L. Y. (2000) · Matrix Biology · doi:10.1016/s0945-053x(00)00100-1 · Cited by 119 · see citing works
The aging of skin: chronoaging versus photoaging.
Oikarinen, A. (1990) · PubMed · Cited by 114 · see citing works
Fibrillin Immunoreactive Fibers Constitute a Unique Network in the Human Dermis: Immunohistochemical Comparison of the Distributions of Fibrillin, Vitronectin, Amyloid P Component, and Orcein Stainable Structures in Normal Skin and Elastosis
Dahlbäck, K., Ljungquist, A., Löfberg, H., Dahlbäck, B., Engvall, E., & Sakai, L. Y. (1990) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12874430 · Cited by 104 · see citing works
Cloning of Full-length Elastin cDNAs from a Human Skin Fibroblast Recombinant cDNA Library: Further Elucidation of Alternative Splicing Utilizing Exon-specific Oligonucleotides
FAZIO, M. J., Olsen, D. R., Kauh, E. A., Baldwin, C. T., Indik, Z. K., Ornstein‐Goldstein, N., Yeh, H., Rosenbloom, J., & Uitto, J. (1988) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12476591 · Cited by 101 · see citing works
Effect of smoking on skin elastic fibres: morphometric and immunohistochemical analysis
Just, M., Ribera, M., Monsó, E., Lorenzo, J. C., & Ferrándiz, C. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2006.07575.x · Cited by 99 · see citing works
Serum Concentrations of Elastin-derived Peptides in Patients with Specific Manifestations of Atherosclerotic Disease
Petersen, E., Wågberg, F., & Ängquist, K. A. (2002) · European Journal of Vascular and Endovascular Surgery · doi:10.1053/ejvs.2002.1750 · Cited by 97 · see citing works
Fibrillin-rich microfibrils of the extracellular matrix: ultrastructure and assembly
Sherratt, M. J., Wess, T. J., Baldock, C., Ashworth, J. L., Purslow, P. P., Shuttleworth, C. A., & Kielty, C. M. (2001) · Micron · doi:10.1016/s0968-4328(99)00082-7 · Cited by 97 · see citing works
Self-citation
[35] Lysyl oxidase: Preparation and role in elastin biosynthesis
Kagan, H. M., & Sullivan, K. A. (1982) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(82)82092-2 · Cited by 89 · see citing works
Fibrillin-rich microfibrils: elastic biopolymers of the extracellular matrix
Kielty, C. M., Wess, T. J., Haston, L., Ashworth, J. L., Sherratt, M. J., & Shuttleworth, C. A. (2002) · Journal of Muscle Research and Cell Motility · doi:10.1023/a:1023479010889 · Cited by 87 · see citing works
Self-citation
Repair of photoaged dermal matrix by topical application of a cosmetic ‘antiageing’ product
Watson, R. E. B., Long, S., Bowden, J. J., Bastrilles, J., Barton, S. P., & Griffiths, C. E. M. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.08364.x · Cited by 84 · see citing works
Self-citation
Fibrillin and elastin expression in skin regenerating from cultured keratinocyte autografts: morphogenesis of microfibrils begins at the dermo-epidermal junction and precedes elastic fiber formation
Raghunath, M., Bächi, T., Meuli, M., Altermatt, S., Gobet, R., Bruckner-Tuderman, L., & Steinmann, B. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12339373 · Cited by 80 · see citing works
A Short-Term Screening Protocol, Using Fibrillin-1 as a Reporter Molecule, for Photoaging Repair Agents
Watson, R. E. B., Craven, N. M., Griffiths, C. E. M., Kang, S., Jones, C. J. P., & Kielty, C. M. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01322.x · Cited by 79 · see citing works
Self-citation
A cosmetic ‘anti-ageing’ product improves photoaged skin: a double-blind, randomized controlled trial
Watson, R. E. B., Ogden, S., Cotterell, L., Bowden, J. J., Bastrilles, J., Long, S., & Griffiths, C. E. M. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09216.x · Cited by 78 · see citing works
Self-citation
N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly
Trask, T. M., Ritty, T. M., Broekelmann, T. J., Tisdale, C., & Mecham, R. P. (1999) · Biochemical Journal · doi:10.1042/bj3400693 · Cited by 75 · see citing works
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Self-citation
Age-related changes in human dermal elastic fibres
Tsuji, T., & Hamada, T. (1981) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1981.tb00882.x · Cited by 72 · see citing works
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Berton, A., Godeau, G., Emonard, H., Baba, K., Bellon, P., Hornebeck, W., & Bellon, G. (2000) · Matrix Biology · doi:10.1016/s0945-053x(00)00057-3 · Cited by 66 · see citing works
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Zhang, M., Pierce, R. A., Wachi, H., Mecham, R. P., & Parks, W. C. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7314 · Cited by 64 · see citing works
Catabolism of intact fibrillin microfibrils by neutrophil elastase, chymotrypsin and trypsin
Kielty, C. M., Woolley, D. E., Whittaker, S. P., & Shuttleworth, C. A. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00818-3 · Cited by 60 · see citing works
Fibrillin assembly: dimer formation mediated by amino-terminal sequences
Ashworth, J. L., Kelly, V., Wilson, R., Shuttleworth, C. A., & Kielty, C. M. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.20.3549 · Cited by 56 · see citing works
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Haynes, S. L., Shuttleworth, C. A., & Kielty, C. M. (1997) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1997.1762185.x · Cited by 54 · see citing works
Smoker's Wrinkles?
Allen, H. B. (1973) · JAMA · doi:10.1001/jama.1973.03220370019004 · Cited by 51 · see citing works
TOPICAL RETINOIC ACID IN ACNE VULGARIS
Pedace, F. J., & Stoughton, R. B. (1971) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1971.tb02533.x · Cited by 48 · see citing works
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Sherratt, M. J., Holmes, D. F., Shuttleworth, C. A., & Kielty, C. M. (2004) · Biophysical Journal · doi:10.1016/s0006-3495(04)74369-6 · Cited by 41 · see citing works
Self-citation
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Farwick, M., Watson, R. E. B., Rawlings, A. V., Wollenweber, U., Lersch, P., Bowden, J. J., Bastrilles, J., & Griffiths, C. E. M. (2007) · International Journal of Cosmetic Science · doi:10.1111/j.1467-2494.2007.00394.x · Cited by 32 · see citing works
Self-citation
Comparison of Clinical and Computerized Image Analyses in the Assessment of Skin Ageing in Smokers and Non-smokers
Raitio, A., Kontinen, J., Rasi, M., Bloigu, R., Röning, J., & Oikarinen, A. (2004) · Acta Dermato Venereologica · doi:10.1080/00015550410014969 · Cited by 24 · see citing works
The area of the dermo‐epidermal junction in human skin
Katzberg, A. A. (1958) · The Anatomical Record · doi:10.1002/ar.1091310408 · Cited by 24 · see citing works
Smokers' Faces
Soffer, A. (1986) · CHEST Journal · doi:10.1378/chest.89.5.622a · Cited by 10 · see citing works
Age-related deterioration in the mechanical function of human dermal fibrillin microfibrils
Sherratt, M. J., Bastrilles, J., Bowden, J., Watson, R., & Griffiths, C. E. M. (2006) · Research Explorer (The University of Manchester) · Cited by 5 · see citing works
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[56]56. ª 2010 The Authors. Journal compilation ª 2010 Society of Cosmetic Scientists and the Socie ´te ´Franc ¸aise de Cosme ´tologie International Journal of Cosmetic Science, 1-10
[84]84. Watson, R.E., Ogden, S., Cotterell, L.F., Bowden, J.J., Bastrilles, J.Y., Long, S.P. et al. Effects of a cosmetic 'anti-ageing' product improves photoaged skin. Br. J. Dermatol. 161, 419-426 (2009). ª 2010 The Authors. Journal compilation ª 2010 Society of Cosmetic Scientists and the Socie ´te ´Franc ¸aise de Cosme ´tologie International Journal of Cosmetic Science, 1-10

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Pająk, J., Szepietowski, J. C., & Nowicka, D. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19159055 · Cited by 18 · see citing works
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Katsuyama, Y., Yamawaki, Y., Sato, Y., Muraoka, S., Yoshida, M., Okano, Y., & Masaki, H. (2022) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2022.10.002 · Cited by 18 · see citing works
Dermal fiber structures and photoaging
Digabel, J. L., Houriez—Gombaud-Saintonge, S., Filiol, J., Lauze, C., & Josse, G. (2018) · Journal of Biomedical Optics · doi:10.1117/1.jbo.23.9.096501 · Cited by 18 · see citing works
In vivo characterization of structural changes after topical application of glucocorticoids in healthy human skin
Jung, S., Lademann, J. M., Darvin, M. E., Richter, C., Pedersen, C. B., Richter, H., Schanzer, S., Kottner, J., Blume‐Peytavi, U., & Røpke, M. A. (2017) · Journal of Biomedical Optics · doi:10.1117/1.jbo.22.7.076018 · Cited by 18 · see citing works
Cosmeceutical bioactivities of isolated compounds from Ligularia fischeri Turcz leaves
Park, C. H., Ahn, M. J., Hwang, G. S., An, S. E., & Whang, W. K. (2016) · Applied Biological Chemistry · doi:10.1007/s13765-016-0189-0 · Cited by 16 · see citing works
Age‐related changes to characteristics of the human eyes in women from six different ethnicities
Flament, F., Francois, G., Seyrek, I., & Saint‐Léger, D. (2020) · Skin Research and Technology · doi:10.1111/srt.12824 · Cited by 16 · see citing works
Predicting the optimum compositions of a transdermal nanoemulsion system containing an extract of Clinacanthus nutans leaves ( L .) for skin antiaging by artificial neural network model
Sulaiman, I. S. C., Basri, M., Masoumi, H. R. F., Ashari, S. E., Basri, H., & Ismail, M. (2017) · Journal of Chemometrics · doi:10.1002/cem.2894 · Cited by 15 · see citing works
Traditional medicine for aging-related disorders: Implications for drug discovery
Banerjee, A., Suresh, P. M., Banu, L. H., Gopikar, A. S. R., Elizabeth, K. R., & Pathak, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820071-1.00004-9 · Cited by 16 · see citing works
Evaluation of aging, diabetes mellitus, and skin wounds by scanning acoustic microscopy with protease digestion
Miura, K., & Yamashita, K. (2018) · Pathobiology of Aging & Age-related Diseases · doi:10.1080/20010001.2018.1516072 · Cited by 15 · see citing works
Anti-ageing skin effects of Korean bamboo salt on SKH1 hairless mice
Zhao, X., Qi, Y., Yi, R., & Park, K. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.07.010 · Cited by 15 · see citing works
A step closer to elastogenesis on demand; Inducing mature elastic fibre deposition in a natural biomaterial scaffold
Almeida-González, F. R., González‐Vázquez, A., Mithieux, S. M., O’Brien, F. J., Weiss, A. S., & Brougham, C. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111788 · Cited by 15 · see citing works
An Optimization-Based Technology Applied for Face Skin Symptom Detection
Liao, Y., Chang, P.-C., Wang, C.-C., & Li, H.-H. (2022) · Healthcare · doi:10.3390/healthcare10122396 · Cited by 14 · see citing works
Ancillary Procedures to Facelift Surgery: What has Changed?
Stein, M. J., & Aston, S. J. (2023) · Aesthetic Surgery Journal Open Forum · doi:10.1093/asjof/ojad063 · Cited by 14 · see citing works
Applications of Elastin in Cosmetics: Prospects and Challenges
Lei, T., Ye, L., Pei, Y., Sun, H., & Guo, C. (2025) · Cosmetics · doi:10.3390/cosmetics12010018 · Cited by 15 · see citing works
Role of Nutritional Elements in Skin Homeostasis: A Review
Jiang, N., Quan, T., Li, R., Chen, Y., & Gao, T. (2025) · Biomolecules · doi:10.3390/biom15060808 · Cited by 15 · see citing works
Protective effects of the antioxidant extract collected from Styela clava tunics on UV radiation-induced skin aging in hairless mice
Koh, E. K., Kim, J. E., Go, J., Song, S. H., Sung, J. E., Son, H. J., Jung, Y. J., Kim, B. H., Jung, Y., & Hwang, D. Y. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2740 · Cited by 14 · see citing works
Inhibition of Ultraviolet‐B Radiation Induced Photodamage by Trigonelline Through Modulation of Mitogen Activating Protein Kinases and Nuclear Factor‐κB Signaling Axis in Skin
Nazir, L. A., Tanveer, M. A., Umar, S. A., Love, S., Divya, G., & Abdullah, S. T. (2020) · Photochemistry and Photobiology · doi:10.1111/php.13369 · Cited by 14 · see citing works
Beauty from within: Oral administration of a sulfur-containing supplement methylsulfonylmethane improves signs of skin ageing
Muizzuddin, N., & Benjamin, R. L. (2020) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000643 · Cited by 16 · see citing works
A blackberry–dill extract combination synergistically increases skin elasticity
Meza, D., Li, W., Seo, I., Parsa, R., Kaur, S., Kizoulis, M. G., & Southall, M. D. (2020) · International Journal of Cosmetic Science · doi:10.1111/ics.12644 · Cited by 13 · see citing works
Oral administration of Jumihaidokuto inhibits UVB-induced skin damage and prostaglandin E2 production in HR-1 hairless mice
Murata, K., Oyama, M., Ogata, M., Fujita, N., & Takahashi, R. (2020) · Journal of Natural Medicines · doi:10.1007/s11418-020-01465-y · Cited by 13 · see citing works
Changes in skin wrinkles and pores due to long‐term mask wear
Park, M., Kim, H., Kim, S., Lee, J., Kim, S., Byun, J. W., Hwang‐Bo, J., & Park, K. H. (2021) · Skin Research and Technology · doi:10.1111/srt.13019 · Cited by 12 · see citing works
In vivo evaluation of topical ascorbic acid application on skin aging by 50 MHz ultrasound
Vergílio, M. M., Aiello, L. M., Furlan, A. S., Caritá, A. C., Azevedo, J. R., Bolzinger, M., Chevalier, Y., & Leonardi, G. R. (2022) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.14892 · Cited by 12 · see citing works
The in vivo effect of L-arginine on skin elasticity in mice
de Souza, Á. D. P. B., de Oliveira, M. M. R., de Andrade, R. R., de Amorim, R. F. B., Bocca, A. L., & Borin, M. D. F. (2017) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902017000300045 · Cited by 13 · see citing works
Antiaging Activity of Peptide Identified from Fermented Trapa Japonica Fruit Extract in Human Dermal Fibroblasts
Jang, J. D., Kim, M.-K., Nam, G. H., Kim, Y.-M., Kang, S. M., Lee, K., & Park, Y.-J. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/5895029 · Cited by 12 · see citing works
Dermal penetration of creatine from a face-care formulation containing creatine, guarana and glycerol is linked to effective antiwrinkle and antisagging efficacy in male subjects
Peirano, R. I., Achterberg, V., Düsing, H., Akhiani, M., Koop, U., Jaspers, S., Krüger, A., Schwengler, H., Hamann, T., Wenck, H., et al. (2011) · Journal of Cosmetic Dermatology · doi:10.1111/j.1473-2165.2011.00579.x · Cited by 12 · see citing works
Effects of Annona muricata Extract on Trypsin, Cathepsin B and Collagenase Activities and Textural Changes in Chilled Macrobrachium rosenbergii
Ibrahim, A., Bakar, K., Bakar, J., Nirmal, N. P., Ikhwanuddin, M., & Karim, N. U. (2023) · Foods · doi:10.3390/foods12091887 · Cited by 11 · see citing works
Methods for characterizing the anisotropic behavior of the human skin’s relief and its mechanical properties in vivo linked to age effects
Ayadh, M., Abellan, M., Helfenstein-Didier, C., Bigouret, A., & Zahouani, H. (2020) · Surface Topography Metrology and Properties · doi:10.1088/2051-672x/ab7c31 · Cited by 11 · see citing works
Facial Expression Wrinkles and Their Relaxation by a Synthetic Peptide
Campiche, R., Pascucci, F., Jiang, L. I., Vergne, T., Cherel, M., Gougeon, S., Prestat‐Marquis, E., Francois, G., Laurent, G., & Gempeler, M. (2020) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-020-10146-z · Cited by 11 · see citing works
Preventive Effects of Anthraquinones Isolated from an Endophytic Fungus, Colletotrichum sp. JS-0367 in Tumor Necrosis Factor-α-Stimulated Damage of Human Dermal Fibroblasts
Lee, S., Nguyen, Q. N., Phung, H. M., Shim, S. H., Kim, D. Y., Hwang, G. S., & Kang, K. S. (2021) · Antioxidants · doi:10.3390/antiox10020200 · Cited by 11 · see citing works
The possible pre -and post -UVA radiation protective effect of amaranth oil on human skin fibroblast cells
Wołosik, K., Zaręba, I., Surażyński, A., & Markowska, A. (2017) · Pharmacognosy Magazine · doi:10.4103/pm.pm_522_15 · Cited by 11 · see citing works
Chikusetsusaponin IVa from Dolichos lablab Linne attenuates UVB-induced skin photoaging in mice by suppressing MAPK/AP-1 signaling
Kim, K. M., Im, A., Shim, K., Seo, C., Lee, Y., Lee, J. H., Yoo, J. S., Choi, S., & Chae, S. (2024) · Applied Biological Chemistry · doi:10.1186/s13765-024-00934-2 · Cited by 10 · see citing works
Photoprotection and Photoaging
Friedman, B. J., Lim, H. W., & Wang, S. Q. (2016) · Springer eBooks · doi:10.1007/978-3-319-29382-0_4 · Cited by 10 · see citing works
Use of formulations for sensitive skin improves the visible signs of aging, including wrinkle size and elasticity
Spada, F., Lui, A. H., & Barnes, T. M. (2019) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s212240 · Cited by 10 · see citing works

Molecular aspects of skin ageing
Naylor, E. C., Watson, R. E. B., & Sherratt, M. J. (2011) · Maturitas · doi:10.1016/j.maturitas.2011.04.011 · Cited by 567 · see citing works
Self-citation
Over-the-counter antiaging products: Science and fiction
Sherratt, M. J. (2017) · Maturitas · doi:10.1016/j.maturitas.2017.03.074
Self-citation
Fibulin-5 Deposition in Human Skin: Decrease with Aging and UVB Exposure and Increase in Solar Elastosis
Amano, S. (2009) · Springer eBooks · doi:10.1007/978-3-540-89656-2_32
The role of elastin and collagen in cutaneous aging: intrinsic aging versus photoexposure.
Uitto, J. (2008) · PubMed · Cited by 296 · see citing works
A Transgenic Mouse Model of Cutaneous Photoaging Measuring Elastin Promoter Activation
Bernstein, E. E. (1997) · Springer eBooks · doi:10.1007/978-3-662-10135-3_6

Authors: Langton, A. K., Sherratt, M. J., Griffiths, C. E. M., & Watson, R. E. B.
Affiliations: Manchester Academic Health Science Centre (GB)
Corresponding author: Watson, R. E. B.
ORCID: Langton, A. K.
Sherratt, M. J.
Griffiths, C. E. M.
Watson, R. E. B.
Venue: International Journal of Cosmetic Science
Publisher: Wiley
Published: 2010-06-21
Volume: 32
Issue: 5
Pages: 330-339
ISSN: 0142-5463 (ISSN-L)
1468-2494
DOI: 10.1111/j.1468-2494.2010.00574.x
OpenAlex: W2129424926
Cited by: 177
References: 84
Citations by year: 2026: 11 · 2025: 18 · 2024: 9 · 2023: 9 · 2022: 13 · 2021: 22 · 2020: 19 · 2019: 14 · 2018: 7 · 2017: 10 · 2016: 11 · 2015: 9 · 2014: 5 · 2013: 10 · 2012: 5
FWCI: 1.12
Type: journal article
Language: en
Open access: green
research.manchester.ac.uk
Licence: other-oa
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: International Journal of Cosmetic Science (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (submittedVersion, other-oa)
Funders: National Institute for Health and Care Research
Manchester Biomedical Research Centre
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
Keywords: skin aging, elastic fibers, intrinsic aging, extrinsic aging, photoaging, UV irradiation, smoking, fibrillin-1, extracellular matrix, anti-aging cosmetics, biomarkers, wrinkles
MeSH terms: Aging, Elastin, Extracellular Matrix, Humans, Protein Conformation, Skin Aging

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