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In vivo gene electroinjection and expression in rat liver
Open accessAbstract
In vivo targeted gene transfer by non‐viral vectors is subjected to anatomical constraints depending on the route of administration. Transfection efficiency and gene expression in vivo using non‐viral vectors is also relatively low. We report that in vivo electropermeabilization of the liver tissue of rats in the presence of genes encoding luciferase or β‐galactosidase resulted in the strong expression of these genetic markers in rat liver cells. About 30–40% of the rat liver cells electroporated expressed the β‐galactosidase genetic marker 48 h after electroporation. The marker expression was also detected at least 21 days after transfection at about 5% of the level 48 h after electroporation. The results indicate that gene transfer by electroporation in vivo may avoid anatomical constraints and low transfection efficiency.
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Cited by
High-efficiency gene transfer into skeletal muscle mediated by electric pulses
Mir, L. M., Bureau, M. F., Gehl, J., Rangara, R., Rouy, D., Caillaud, J.-M., Delaere, P., Branellec, D., Schwartz, B., & Scherman, D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4262 · Cited by 914
Electroporation-Based Technologies for Medicine: Principles, Applications, and Challenges
Yarmush, M. L., Golberg, A., Serša, G., Kotnik, T., & Miklavčič, D. (2014) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071813-104622 · Cited by 889
Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts
Stewart, M. P., Langer, R., & Jensen, K. F. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00678 · Cited by 747
Increased DNA Vaccine Delivery and Immunogenicity by Electroporation In Vivo
Widera, G., Austin, M., Rabussay, D., Goldbeck, C., Barnett, S. W., Chen, M., Leung, L., Otten, G. R., Thudium, K., Selby, M. J., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.9.4635 · Cited by 606
Gothelf, A., Mir, L. M., & Gehl, J. (2003) · Cancer Treatment Reviews · doi:10.1016/s0305-7372(03)00073-2 · Cited by 549
Metadata
- Authors
- Heller, R., Jaroszeski, M., Atkin, A., Moradpour, D., Gilbert, R., Wands, J., & Nicolau, C.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1996-07-08
- Volume
- 389
- Issue
- 3
- Pages
- 225-228
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2054457322
- Cited by
- 430
- References
- 0
- FWCI
- 13.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Heller, R., Jaroszeski, M., Atkin, A., Moradpour, D., Gilbert, R., Wands, J., & Nicolau, C. (1996). In vivo gene electroinjection and expression in rat liver. FEBS Letters. https://doi.org/10.1016/0014-5793(96)00590-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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