Histometric and serial section observations of the intrahepatic bile ducts in primary biliary cirrhosis

Progress in Liver Diseases

(1965) · Elsevier eBooks · doi:10.1016/c2013-0-06663-7 · Cited by 664

Liver Biopsy Interpretation

(1959) · Postgraduate Medical Journal · doi:10.1136/pgmj.45.522.305-d · Cited by 499

CELLULAR IMMUNITY AND HEPATITIS-ASSOCIATED, AUSTRALIA ANTIGEN LIVER DISEASE

Dudley, F. J., Fox, R. A., & Sherlock, S. (1972) · The Lancet · doi:10.1016/s0140-6736(72)90234-6 · Cited by 487

PRIMARY BILIARY CIRRHOSIS. CHRONIC NON-SUPPURATIVE DESTRUCTIVE CHOLANGITIS.

Rubin, E., Schaffner, F., & Pópper, H. (1965) · PubMed Central · Cited by 374

IS PRIMARY BILIARY CIRRHOSIS AN IMMUNE COMPLEX DISEASE?

Thomas, H. C., Potter, B. J., & Sherlock, S. (1977) · The Lancet · doi:10.1016/s0140-6736(77)92666-6 · Cited by 121

Liver Biopsy Interpretation

Knisely, A. S. (2001) · Gut · doi:10.1136/gut.49.5.740c · Cited by 95

Histogenesis of hepatic cirrhosis studied by the threedimensional approach.

Pópper, H., & Elias, H. (1955) · PubMed Central · Cited by 73

The Pathology of Primary Biliary Cirrhosis with Emphasis on Histogenesis

Baggenstoss, A. H., Foulk, W. T., Butt, H. R., & Bahn, R. C. (1964) · American Journal of Clinical Pathology · doi:10.1093/ajcp/42.3.259 · Cited by 72

Effect of d-Penicillamine on Copper Retention in Patients with Primary Biliary Cirrhosis

Deering, T. B., Dickson, E. R., Fleming, C. R., Geall, M. G., McCall, J., & Baggenstoss, A. H. (1977) · Gastroenterology · doi:10.1016/s0016-5085(77)80012-7 · Cited by 67

Effect of D-penicillamine on copper retention in patients with primary billiary cirrhosis.

Deering, T. B., Dickson, E. R., Fleming, C. R., Geall, M. G., McCall, J., & Baggenstoss, A. H. (1977) · PubMed · Cited by 65

Update of the International Banff Schema for liver allograft rejection: Working recommendations for the histopathologic staging and reporting of chronic rejection

Demetris, A. J., Adams, D., Bellamy, C. O. C., Blakolmer, K., Clouston, A. D., Dhillon, A. P., Fung, J. J., Gouw, A. S. H., Gustafsson, B., Haga, H., et al. (2000) · Hepatology · doi:10.1002/hep.510310337 · Cited by 541

The normal adult human liver biopsy: A quantitative reference standard

Crawford, A. R., Lin, X., & Crawford, J. M. (1998) · Hepatology · doi:10.1002/hep.510280206 · Cited by 312

Microstructure and development of the normal and pathologic biliary tract in humans, including blood supply

Nakanuma, Y., Hoso, M., Sanzen, T., & Sasaki, M. (1997) · Microscopy Research and Technique · doi:10.1002/(sici)1097-0029(19970915)38:6 · Cited by 282

Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens: Interobserver agreement

Nakanuma, Y., Zen, Y., Harada, K., Sasaki, M., Nonomura, A., Uehara, T., Sano, K., Kondo, F., Fukusato, T., Tsuneyama, K., et al. (2010) · Pathology International · doi:10.1111/j.1440-1827.2009.02500.x · Cited by 224

Is Liver Biopsy Useful in the Evaluation of Patients with Chronically Elevated Liver Enzymes?

Ness, M. M. V., & Diehl, A. M. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-111-6-473 · Cited by 209

Comparison of the Clinicopathologic Features of Primary Sclerosing Chol-angitis and Primary Biliary Cirrhosis

Wiesner, R. H., LaRusso, N. F., Ludwig, J., & Dickson, E. R. (1985) · Gastroenterology · doi:10.1016/s0016-5085(85)80141-4 · Cited by 192

Primary biliary cirrhosis

Hübscher, S. G., Elias, E., Buckels, J. A. C., Mayer, A. D., McMaster, P. D., & Neuberger, J. (1993) · Journal of Hepatology · doi:10.1016/s0168-8278(05)80244-2 · Cited by 180

Idiopathic adulthood ductopenia

Ludwig, J., Wiesner, R. H., & LaRusso, N. F. (1988) · Journal of Hepatology · doi:10.1016/s0168-8278(88)80482-3 · Cited by 175

Primary biliary cholangitis.

Tanaka, A., Ma, X., Takahashi, A., & Vierling, J. M. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01303-5 · Cited by 177

Enhanced apoptosis relates to bile duct loss in primary biliary cirrhosis

Harada, K., Ozaki, S., Gershwin, M. E., & Nakanuma, Y. (1997) · Hepatology · doi:10.1002/hep.510260604 · Cited by 167

Current concepts in cell-mediated hepatic allograft rejection leading to ductopenia and liver failure

Wiesner, R. H., Ludwig, J., van Hoek, B., & Krom, R. A. F. (1991) · Hepatology · doi:10.1002/hep.1840140424 · Cited by 167

A histometric analysis of chronically rejected human liver allografts: Insights into the mechanisms of bile duct loss: Direct immunologic and ischemic factors

Oguma, S., Belle, S. H., Starzl, T. E., & Demetris, J. A. (1989) · Hepatology · doi:10.1002/hep.1840090207 · Cited by 166

Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts†

Isse, K., Harada, K., Zen, Y., Kamihira, T., Shimoda, S., Harada, M., & Nakanuma, Y. (2005) · Hepatology · doi:10.1002/hep.20582 · Cited by 157

Sequential and diagnostic features in primary biliary cirrhosis based on serial histologic study in 209 patients

Portmann, B. C., Pópper, H., Neuberger, J., & Williams, R. L. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90001-0 · Cited by 135

Histopathology of Early and Late Human Hepatic Allograft Rejection: Evidence of Progressive Destruction of Interlobular Bile Ducts

Vierling, J. M., & Fennell, R. H. (1985) · Hepatology · doi:10.1002/hep.1840050603 · Cited by 128

Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence†

Sasaki, M., Ikeda, H., Yamaguchi, J., Nakada, S., & Nakanuma, Y. (2008) · Hepatology · doi:10.1002/hep.22348 · Cited by 125

Multiple cysts in the hepatic hilum and their pathogenesis

Nakanuma, Y., Kurumaya, H., & Ohta, G. (1984) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00695218 · Cited by 122

Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss

Sasaki, M., Ikeda, H., Haga, H., Manabe, T., & Nakanuma, Y. (2005) · The Journal of Pathology · doi:10.1002/path.1729 · Cited by 122

Pathologic features of hepatolithiasis in Japan

Nakanuma, Y., Yamaguchi, K., Ohta, G., & Terada, T. (1988) · Human Pathology · doi:10.1016/s0046-8177(88)80150-3 · Cited by 116

Expression of blood group-related antigens in the intrahepatic biliary tree and hepatocytes in normal livers and various hepatobiliary diseases

Nakanuma, Y., & Sasaki, M. (1989) · Hepatology · doi:10.1002/hep.1840100209 · Cited by 115

Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis

Sasaki, M., Miyakoshi, M., Sato, Y., & Nakanuma, Y. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.56 · Cited by 114

Pathology and pathogenesis of intrahepatic bile duct loss

Nakanuma, Y., Tsuneyama, K., & Harada, K. (2001) · Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.1007/s005340170002 · Cited by 113

Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis

Sasaki, M., Miyakoshi, M., Sato, Y., & Nakanuma, Y. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.03.008 · Cited by 112

Idiopathic Adulthood Ductopenia: An Update

Ludwig, J. (1998) · Mayo Clinic Proceedings · doi:10.4065/73.3.285 · Cited by 111

Abnormal expression of the E2 component of the pyruvate dehydrogenase complex on the luminal surface of biliary epithelium occurs before major histocompatibility complex class II and BB1/B7 expression

Tsuneyama, K., de Water, J. V., Leung, P. S. C., Cha, S.-H., Nakanuma, Y., Kaplan, M., Lellis, R. D., Coppel, R. L., Ansari, A. A., & Gershwin, E. M. (1995) · Hepatology · doi:10.1002/hep.1840210422 · Cited by 111

Precancerous lesions of intrahepatic cholangiocarcinoma

Shimonishi, T., Sasaki, M., & Nakanuma, Y. (2000) · Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.1007/s005340070002 · Cited by 107

Pathologic Features and Evolution of Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis

Scheuer, P. J. (1998) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)63652-5 · Cited by 106

Alterations in Tight Junctions Differ Between Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis

Sakisaka, S., Kawaguchi, T., Taniguchi, E., Hanada, S., Sasatomi, K., Koga, H., Harada, M., Kimura, R., Sata, M., Sawada, N., et al. (2001) · Hepatology · doi:10.1053/jhep.2001.25086 · Cited by 106

Increased cd1d expression on small bile duct epithelium and epithelioid granuloma in livers in primary biliary cirrhosis

Tsuneyama, K., Yasoshima, M., Harada, K., Hiramatsu, K., Gershwin, M. E., & Nakanuma, Y. (1998) · Hepatology · doi:10.1002/hep.510280303 · Cited by 103

Molecular identification of bacterial 16S ribosomal RNA gene in liver tissue of primary biliary cirrhosis: Is Propionibacterium acnes involved in granuloma formation?

Harada, K. (2001) · Hepatology · doi:10.1053/jhep.2001.22653 · Cited by 100

Antibiotic-associated acute vanishing bile duct syndrome: A pattern associated with severe, prolonged, intrahepatic cholestasis

Davies, M. H., Harrison, R. F., Elias, E., & Hübscher, S. G. (1994) · Journal of Hepatology · doi:10.1016/s0168-8278(05)80476-3 · Cited by 95

Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway: A culture study

Sasaki, M., Ikeda, H., Sato, Y., & Nakanuma, Y. (2008) · Free Radical Research · doi:10.1080/10715760802244768 · Cited by 90

Primary Biliary Cholangitis: Its Pathological Characteristics and Immunopathological Mechanisms

Tsuneyama, K., Baba, H., Morimoto, Y., Tsunematsu, T., & Ogawa, H. (2017) · The Journal of Medical Investigation · doi:10.2152/jmi.64.7 · Cited by 89

Th1 cytokine–induced downregulation of PPARγ in human biliary cells relates to cholangitis in primary biliary cirrhosis†

Harada, K., Isse, K., Kamihira, T., Shimoda, S., & Nakanuma, Y. (2005) · Hepatology · doi:10.1002/hep.20705 · Cited by 88

Intrahepatic peribiliary vascular plexus in various hepatobiliary diseases: A histological survey

Kobayashi, S., Nakanuma, Y., & Matsui, O. (1994) · Human Pathology · doi:10.1016/0046-8177(94)90016-7 · Cited by 89

Incidence of and risk factors for hepatocellular carcinoma in primary biliary cirrhosis: National data from Japan

Harada, K., Hirohara, J., Ueno, Y., Nakano, T., Kakuda, Y., Tsubouchi, H., Ichida, T., & Nakanuma, Y. (2013) · Hepatology · doi:10.1002/hep.26176 · Cited by 87

Decreased Expression of Bmi1 Is Closely Associated with Cellular Senescence in Small Bile Ducts in Primary Biliary Cirrhosis

Sasaki, M., Ikeda, H., Sato, Y., & Nakanuma, Y. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051237 · Cited by 87

Distinct MicroRNAs Expression Profile in Primary Biliary Cirrhosis and Evaluation of miR 505-3p and miR197-3p as Novel Biomarkers

Ninomiya, M., Kondo, Y., Funayama, R., Nagashima, T., Kogure, T., Kakazu, E., Kimura, O., Ueno, Y., Nakayama, K., & Shimosegawa, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066086 · Cited by 83

Expression profiles of MUC mucins and trefoil factor family (TFF) peptides in the intrahepatic biliary system: Physiological distribution and pathological significance

Sasaki, M., Ikeda, H., & Nakanuma, Y. (2007) · Progress in Histochemistry and Cytochemistry · doi:10.1016/j.proghi.2007.02.001 · Cited by 79

Intrahepatic peribiliary glands of humans. I. Anatomy, development and presumed functions

Nakanuma, Y., Katayanagi, K., Terada, T., & Saito, K. (1994) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.1994.tb01220.x · Cited by 75

Chemokine–Chemokine Receptor CCL2–CCR2 and CX3CL1–CX3CR1 Axis May Play a Role in the Aggravated Inflammation in Primary Biliary Cirrhosis

Sasaki, M., Miyakoshi, M., Sato, Y., & Nakanuma, Y. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-013-2920-6 · Cited by 75

HIGH INCIDENCE OF ANTITISSUE ANTIBODIES IN PATIENTS EXPERIENCING CHRONIC LIVER ALLOGRAFT REJECTION1

Dubel, L., Farges, O., Johanet, C., Sebagh, M., & Bismuth, H. (1998) · Transplantation · doi:10.1097/00007890-199804270-00011 · Cited by 73

The effect of environmental cues on the differentiation of myofibroblasts in peritoneal granulation tissue

(2000) · doi:10.1002/1096-9896(2000)9999:9999 · Cited by 70

Proposal of a new staging and grading system of the liver for primary biliary cirrhosis

Hiramatsu, K., Aoyama, H., Zen, Y., Aishima, S., Kitagawa, S., & Nakanuma, Y. (2006) · Histopathology · doi:10.1111/j.1365-2559.2006.02537.x · Cited by 69

A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis

Sasaki, M., Miyakoshi, M., Sato, Y., & Nakanuma, Y. (2014) · Journal of Gastroenterology · doi:10.1007/s00535-014-1033-0 · Cited by 70

Increased expression of mitochondrial proteins associated with autophagy in biliary epithelial lesions in primary biliary cirrhosis

Sasaki, M., Miyakoshi, M., Sato, Y., & Nakanuma, Y. (2012) · Liver International · doi:10.1111/liv.12049 · Cited by 69

Histopathology of the intrahepatic biliary tree

Desmet, V. J. (1983) · Liver International · doi:10.1111/j.1600-0676.1983.tb00865.x · Cited by 67

The emerging role of circulating microRNAs as biomarkers in autoimmune diseases

Zeng, L., Cui, J., Wu, H., & Lu, Q. (2014) · Autoimmunity · doi:10.3109/08916934.2014.929667 · Cited by 64

Abnormal expression of PDC-E2 on the apical surface of biliary epithelial cells in patients with antimitochondrial antibody-negative primary biliary cirrhosis

Tsuneyama, K., de Water, J. V., Thiel, D. H. V., Coppel, R. L., Ruebner, B. H., Nakanuma, Y., Dickson, R. E., & Gershwin, E. M. (1995) · Hepatology · doi:10.1002/hep.1840220517 · Cited by 71

CHRONIC REJECTION OF THE LIVER ALLOGRAFT

Lowes, J. R., Hübscher, S. G., & Neuberger, J. (1993) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(21)00075-3 · Cited by 63

Adhesion molecule expression in primary sclerosing cholangitis and primary biliary cirrhosis.

Bloom, S. L., Fleming, K. A., & Chapman, R. W. (1995) · Gut · doi:10.1136/gut.36.4.604 · Cited by 61

Scavenger cells with Gram-positive bacterial lipoteichoic acid infiltrate around the damaged interlobular bile ducts of primary biliary cirrhosis

Tsuneyama, K., Harada, K., Kono, N., Hiramatsu, K., Zen, Y., Sudo, Y., Gershwin, M. E., Ikemoto, M., Arai, H., & Nakanuma, Y. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00084-8 · Cited by 61

Nonsyndromic Paucity of Intrahepatic Bile Ducts in Infancy and Idiopathic Ductopenia in Adulthood: the Same Syndrome?

Bruguera, M., Llach, J., & Rodés, J. (1992) · Hepatology · doi:10.1002/hep.1840150514 · Cited by 61

Animal Models of Primary Biliary Cirrhosis

Katsumi, T., Tomita, K., Leung, P. S. C., Yang, G., Gershwin, M. E., & Ueno, Y. (2015) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8482-y · Cited by 60

A possible involvement of p62/sequestosome‐1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis

Sasaki, M., Miyakoshi, M., Sato, Y., & Nakanuma, Y. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02656.x · Cited by 59

Expression of antigens related to apoptosis and cell proliferation in chronic nonsuppurative destructive cholangitis in primary biliary cirrhosis

Kuroki, T., Seki, S., Kawakita, N., Nakatani, K., Kitada, T., Sakaguchi, H., & Hisa, T. (1996) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00192434 · Cited by 58

Procollagen-positive fibroblasts predominantly express fibrogenic growth factors and their receptors in human encapsulation process against foreign body

Katou, F., Ohtani, H., Nagura, H., & Motegi, K. (1998) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(1998100)186:2 · Cited by 18

Enhanced Hepatic Nrf2 Activation After Ursodeoxycholic Acid Treatment in Patients with Primary Biliary Cirrhosis

Kawata, K., Kobayashi, Y., Souda, K., Kawamura, K., Sumiyoshi, S., Takahashi, Y., Noritake, H., Watanabe, S., Suehiro, T., & Nakamura, H. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2903 · Cited by 60

Primary Biliary Cirrhosis: The Molecule and the Mimic

Coppel, R. L., & Gershwin, M. E. (1995) · Immunological Reviews · doi:10.1111/j.1600-065x.1995.tb00064.x · Cited by 55

Diseases of the bile ducts

Nakanuma, Y., Zen, Y., & Portmann, B. C. (2012) · MacSween's Pathology of the Liver · doi:10.1016/b978-0-7020-3398-8.00010-6 · Cited by 56

Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: An immunohistochemical study

Sasaki, M., Ikeda, H., & Nakanuma, Y. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2008.03.005 · Cited by 55

Destruction of canals of hering in primary biliary cirrhosis

Saxena, R., Hytiroglou, P., Thung, S. N., & Theise, N. D. (2002) · Human Pathology · doi:10.1053/hupa.2002.128060 · Cited by 54

Isolation, culture and characterization of biliary epithelial cells from different anatomical levels of the intrahepatic and extrahepatic biliary tree from a mouse

Katayanagi, K., Kono, N., & Nakanuma, Y. (1998) · Liver International · doi:10.1111/j.1600-0676.1998.tb00133.x · Cited by 54

Quantitation of Hepatic Granulomas and Epithelioid Cells in Primary Biliary Cirrhosis

Nakanuma, Y., & Ohta, G. (1983) · Hepatology · doi:10.1002/hep.1840030323 · Cited by 54

Clinicopathological study of primary biliary cirrhosis negative for antimitochondrial antibodies

Nakanuma, Y., Harada, K., Kaji, K., Terasaki, S., Tsuneyama, K., MOTEKI, S., de Water, J. V., Leung, P. S. C., & Gershwin, M. E. (1997) · Liver International · doi:10.1111/j.1600-0676.1997.tb01033.x · Cited by 51

Ultrastructural and immunohistochemical studies of the intrahepatic peribiliary capillary plexus in normal livers and extrahepatic biliary obstruction in human beings

Kono, N., & Nakanuma, Y. (1992) · Hepatology · doi:10.1002/hep.1840150310 · Cited by 51

Immunohistochemical demonstration of pancreatic α-amylase and trypsin in intrahepatic bile ducts and peribiliary glands

Terada, T., & Nakanuma, Y. (1991) · Hepatology · doi:10.1002/hep.1840140629 · Cited by 51

Thalidomide as therapy for primary biliary cirrhosis: a double-blind placebo controlled pilot study

McCormick, P. A., SCOTT, F. R., Epstein, O., Burroughs, A. K., Scheuer, P. J., & McIntyre, N. (1994) · Journal of Hepatology · doi:10.1016/s0168-8278(94)80092-8 · Cited by 51

Enhanced Hepatic Lipid Peroxidation in Patients With Primary Biliary Cirrhosis

Kawamura, K., Kobayashi, Y., Kageyama, F., Kawasaki, T., Nagasawa, M., Toyokuni, S., Uchida, K., & Nakamura, H. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.03300.x · Cited by 50

Expression of HLA-DR antigens on interlobular bile ducts in primary biliary cirrhosis and other hepatobiliary diseases: An immunohistochemical study

Nakanuma, Y., & Kono, N. (1991) · Human Pathology · doi:10.1016/0046-8177(91)90127-b · Cited by 50

Accumulating CD57 + CD3 + natural killer T cells are related to intrahepatic bile duct lesions in primary biliary cirrhosis

Harada, K., Isse, K., Tsuneyama, K., Ohta, H., & Nakanuma, Y. (2003) · Liver International · doi:10.1034/j.1600-0676.2003.00807.x · Cited by 49

Innervation of intrahepatic bile ducts and peribiliary glands in normal human livers, extrahenatic biliary obstruction and hepatolithiasis

Terada, T., & Nakanuma, Y. (1989) · Journal of Hepatology · doi:10.1016/0168-8278(89)90044-5 · Cited by 48

An impaired biliary bicarbonate umbrella may be involved in dysregulated autophagy in primary biliary cholangitis

Sasaki, M., Sato, Y., & Nakanuma, Y. (2018) · Laboratory Investigation · doi:10.1038/s41374-018-0045-4 · Cited by 47

Increased expression of WAF1 in intrahepatic bile ducts in primary biliary cirrhosis relates to apoptosis

Harada, K., Furubo, S., Ozaki, S., Hiramatsu, K., Sudo, Y., & Nakanuma, Y. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(00)00075-1 · Cited by 47

Application and validation of a new histologic staging and grading system for primary biliary cirrhosis

Harada, K., Hsu, M., Ikeda, H., Zeniya, M., & Nakanuma, Y. (2013) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31827234e4 · Cited by 46

A Spectrum of Histopathologic Findings in Autoimmune Liver Disease

Terracciano, L., Patzina, R. A., Lehmann, F. S., Tornillo, L., Cathomas, G., Mhawech, P., Vecchione, R., & Bianchi, L. (2000) · American Journal of Clinical Pathology · doi:10.1309/bhym-hmy5-vm1p-7geg · Cited by 43

Relationship of Pretransplant Hepatobiliary Disease to Bile Duct Damage Occurring in the Liver Allograft

Fennell, R. H., Shikes, R. H., & Vierling, J. M. (1983) · Hepatology · doi:10.1002/hep.1840030114 · Cited by 44

Distribution of B lymphocytes in nonsuppurative cholangitis in primary biliary cirrhosis

Nakanuma, Y. (1993) · Hepatology · doi:10.1002/hep.1840180315 · Cited by 44

Three‐dimensional reconstruction of biliary pathways in primary biliary cirrhosis: A computer‐assisted study

Yamada, S., Howe, S., & Scheuer, P. J. (1987) · The Journal of Pathology · doi:10.1002/path.1711520410 · Cited by 43

Secretory component and immunoglobulins in the intrahepatic biliary tree and peribiliary gland in normal livers and hepatolithiasis

Sugiura, H., & Nakanuma, Y. (1989) · Gastroenterologia Japonica · doi:10.1007/bf02774329 · Cited by 43

Naturally-occurring regulatory T cells are increased in inflamed portal tracts with cholangiopathy in primary biliary cirrhosis

Sasaki, M., Ikeda, H., Sawada, S., Sato, Y., & Nakanuma, Y. (2006) · Journal of Clinical Pathology · doi:10.1136/jcp.2006.044776 · Cited by 40

The pathology of primary biliary cirrhosis and autoimmune cholangitis

Ludwig, J. (2000) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.2000.0106 · Cited by 40

Electron microscopic observation of destruction of biliary epithelium in primary biliary cirrhosis

Nakanuma, Y., Ohta, G., Kono, N., KOBAYASHI, K. P., & Kato, Y. (1983) · Liver International · doi:10.1111/j.1600-0676.1983.tb00874.x · Cited by 40

Human Combinatorial Autoantibodies and Mouse Monoclonal Antibodies to Pdc–E2 Produce Abnormal Apical Staining of Salivary Glands in Patients With Coexistent Primary Biliary Cirrhosis and Sjogren's Syndrome

Tsuneyama, K., de Water, J. V., Nakanuma, Y., Cha, S.-H., Ansari, A., Coppel, R. L., & Gershwin, E. M. (1994) · Hepatology · doi:10.1002/hep.1840200418 · Cited by 39

Molecular mechanisms of cholangiopathy in primary biliary cirrhosis

Harada, K., & Nakanuma, Y. (2006) · Medical Molecular Morphology · doi:10.1007/s00795-006-0321-z · Cited by 38

Animal Models of Primary Biliary Cirrhosis

Chuang, Y., Ridgway, W. M., Ueno, Y., & Gershwin, M. E. (2008) · Clinics in Liver Disease · doi:10.1016/j.cld.2008.02.011 · Cited by 38

Osteopontin is involved in the formation of epithelioid granuloma and bile duct injury in primary biliary cirrhosis

Harada, K., Ozaki, S., Sudo, Y., Tsuneyama, K., Ohta, H., & Nakanuma, Y. (2003) · Pathology International · doi:10.1046/j.1440-1827.2003.01426.x · Cited by 36

Epithelioid cell granulomas in chronic hepatitis C: immunohistochemical character and histological marker of favourable response to interferon‐α therapy

Harada, K., Minato, H., Hiramatsu, K., & Nakanuma, Y. (1998) · Histopathology · doi:10.1046/j.1365-2559.1998.00497.x · Cited by 36

Significance of periductal Langerhans cells and biliary epithelial cell-derived macrophage inflammatory protein-3α in the pathogenesis of primary biliary cirrhosis

Harada, K., Shimoda, S., Ikeda, H., Chiba, M., Hsu, M., Sato, Y., Kobayashi, M., Ren, X. S., Ohta, H., Kasashima, S., et al. (2010) · Liver International · doi:10.1111/j.1478-3231.2010.02367.x · Cited by 35

Cholangiopathy with Respect to Biliary Innate Immunity

Harada, K., & Nakanuma, Y. (2011) · International Journal of Hepatology · doi:10.1155/2012/793569 · Cited by 34

MiR-139-5p is associated with inflammatory regulation through c-FOS suppression, and contributes to the progression of primary biliary cholangitis

Katsumi, T., Ninomiya, M., Nishina, T., Mizuno, K., Tomita, K., Haga, H., Okumoto, K., Saito, T., Shimosegawa, T., & Ueno, Y. (2016) · Laboratory Investigation · doi:10.1038/labinvest.2016.95 · Cited by 34

A comparative histological and morphometric study of vascular changes in idiopathic portal hypertension and alcoholic fibrosis/cirrhosis

Tsuneyama, K., Ohba, K., Zen, Y., Sato, Y., Niwa, H., Minato, H., & Nakanuma, Y. (2003) · Histopathology · doi:10.1046/j.1365-2559.2003.01658.x · Cited by 34

Bile Acids and Deregulated Cholangiocyte Autophagy in Primary Biliary Cholangitis

Sasaki, M., & Nakanuma, Y. (2017) · Digestive Diseases · doi:10.1159/000450913 · Cited by 33

Quantitative analysis of macrophages and perisinusoidal cells in primary biliary cirrhosis

Mathew, J. P., Hines, J. E., Toole, K., Johnson, S. J., James, O., & Burt, A. D. (1994) · Histopathology · doi:10.1111/j.1365-2559.1994.tb00599.x · Cited by 33

Chronic liver allograft rejection and obliterative arteriopathy: possible pathogenic mechanisms.

Oguma, S., Zerbe, T. R., Banner, B. F., Belle, S. H., Starzl, T. E., & Demetris, A. J. (1989) · PubMed · Cited by 31

Definition and pathology of primary sclerosing cholangitis

Nakanuma, Y., Harada, K., Katayanagi, K., Tsuneyama, K., & Sasaki, M. (1999) · Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.1007/s005340050127 · Cited by 28

Distribution of apoptotic cells and expression of apoptosis‐related proteins along the intrahepatic biliary tree in normal and non‐biliary diseased liver

Harada, K., Iwata, M., Kono, N., Koda, W., Shimonishi, T., & Nakanuma, Y. (2000) · Histopathology · doi:10.1046/j.1365-2559.2000.00982.x · Cited by 28

Biliary epithelial expression of pyruvate dehydrogenase complex in primary biliary cirrhosis: An immunohistochemical and immunoelectron microscopic study

Nakanuma, Y., Tsuneyama, K., Kono, N., Hoso, M., de Water, J. V., & Gershwin, M. E. (1995) · Human Pathology · doi:10.1016/0046-8177(95)90120-5 · Cited by 28

Site‐characteristic expression and induction of trefoil factor family 1, 2 and 3 and malignant brain tumor‐1 in normal and diseased intrahepatic bile ducts relates to biliary pathophysiology

Sasaki, M., Tsuneyama, K., Saito, T., Kataoka, H., Mollenhauer, J., Poustka, A., & Nakanuma, Y. (2004) · Liver International · doi:10.1111/j.1478-3231.2004.00883.x · Cited by 28

A MORPHOLOGICAL STUDY ON BILE DUCT LESIONS IN PRIMARY BILIARY CIRRHOSIS

Katsuhisa, S. U. K. A., Yamada, S., & Sekiguchi, T. (1980) · Kitakantou igaku/Kitakantō Igaku · doi:10.2974/kmj1951.30.5_303

Bile duct lesions and diminution in number of intrahepatic bile ducts in asymptomatic primary biliary cirrhosis.

Yamada, S., Takezawa, J., Nagamine, T., Ichikawa, K., Arai, T., & KOBAYASHI, S. (1985) · Japanese Journal of Medicine · doi:10.2169/internalmedicine1962.24.109 · Cited by 1

Pathology of septum formation in primary biliary cirrhosis: A histological study in the non-cirrhotic stage

Nakanuma, Y. (1991) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf01605071 · Cited by 18

Ultrastructural changes of bile duct epithelium in primary biliary cirrhosis in relation to progression of bile duct loss

Nakanuma, Y., Kono, N., Ohta, G., Kato, Y., & KOBAYASHI, K. P. (1982) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00618866 · Cited by 21

Correlation between disappearance of the intrahepatic bile ducts and histologic changes in the liver in primary biliary cirrhosis.

Nakanuma, Y., Miyamura, H., Ohta, G., Kobayashi, K., Kato, Y., & Hattori, N. (1981) · PubMed · Cited by 13