The DOI matches its Crossref record; 16 of the 18 references it cites were found in a registry or an index.
Histometric and serial section observations of the intrahepatic bile ducts in primary biliary cirrhosis
Open accessAbstract
Histometric examinations, based on the assumption that hepatic arterial branches and bile ducts run parallel within the portal tracts, suggest that in primary biliary cirrhosis bile ducts with a lumen (the smallest diameter between the subepithelial basal membranes) below 70--80 micron are destroyed. The smaller the ducts, the more they destroyed. Extensive destruction of the ducts was seen more frequently in the nonfibrotic stage of primary biliary cirrhosis than in later stages. Serial sections of the intrahepatic bile ducts in primary biliary cirrhosis revealed three types of periductal lesions preceding the disappearance of bile ducts: (A) periductal cellular reaction including features of chronic nonsuppurative destructive cholangitis, (B) periductal edema, and (C) periductal fibrosis. In the nonfibrotic stage, types A and C were frequent, whereas in the fibrotic stage types A and B were increased, and type C was predominant in the cirrhotic stage.
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“The characteristic histopathological lesion in primary biliary cholangitis, chronic non-suppurative destructive cholangitis, involves lymphocytic infiltration and destruction of the biliary epithelia of small-calibre to medium-calibre interlobular bile ducts (figure 1), 6 ultimately leading to bile duct destruction (ductopenia) and cholestasis.”
From Primary biliary cholangitis. (2024) · cites this paper as [6]
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Cites
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Harada, Y. K. K. (2015) · Journal of Clinical & Experimental Pathology · doi:10.4172/2161-0681.1000234
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Intrahepatische Gallenwegserkrankungen
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Pathogenic Mechanisms in Primary Biliary Cirrhosis
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Adult Cholestatic and Bile Duct Diseases
Park, B. U., & Chen, Z. E. (2025) · Pracatical anatomic pathology · doi:10.1007/978-3-031-97506-6_10
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Metadata
- Authors
- Nakanuma, Y., & Ohta, G.
- Affiliations
- Kanazawa University (JP)
- ORCID
- Nakanuma, Yasuni
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1979-06
- Volume
- 76
- Issue
- 6
- Pages
- 1326-1332
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1503866127
- Cited by
- 213
- References
- 18
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2018: 2 · 2017: 6 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 7 · 2012: 3
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- primary biliary cirrhosis, intrahepatic bile ducts, bile duct destruction, periductal fibrosis, portal tract, histomorphometry, disease stage
- MeSH terms
- Adult, Aged, Arteries, Bile Ducts, Intrahepatic, Female, Humans, Hyperplasia, Japan, Liver, Liver Circulation, Liver Cirrhosis, Biliary, Male, Middle Aged
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