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Histometric and serial section observations of the intrahepatic bile ducts in primary biliary cirrhosis
Open accessAbstract
Histometric examinations, based on the assumption that hepatic arterial branches and bile ducts run parallel within the portal tracts, suggest that in primary biliary cirrhosis bile ducts with a lumen (the smallest diameter between the subepithelial basal membranes) below 70--80 micron are destroyed. The smaller the ducts, the more they destroyed. Extensive destruction of the ducts was seen more frequently in the nonfibrotic stage of primary biliary cirrhosis than in later stages. Serial sections of the intrahepatic bile ducts in primary biliary cirrhosis revealed three types of periductal lesions preceding the disappearance of bile ducts: (A) periductal cellular reaction including features of chronic nonsuppurative destructive cholangitis, (B) periductal edema, and (C) periductal fibrosis. In the nonfibrotic stage, types A and C were frequent, whereas in the fibrotic stage types A and B were increased, and type C was predominant in the cirrhotic stage.
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“The characteristic histopathological lesion in primary biliary cholangitis, chronic non-suppurative destructive cholangitis, involves lymphocytic infiltration and destruction of the biliary epithelia of small-calibre to medium-calibre interlobular bile ducts (figure 1), 6 ultimately leading to bile duct destruction (ductopenia) and cholestasis.”
From Primary biliary cholangitis. (2024) · cites this paper as [6]
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- Authors
- Nakanuma, Y., & Ohta, G.
- Affiliations
- Kanazawa University (JP)
- ORCID
- Nakanuma, Yasuni
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1979-06
- Volume
- 76
- Issue
- 6
- Pages
- 1326-1332
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1503866127
- Cited by
- 213
- References
- 18
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2018: 2 · 2017: 6 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 7 · 2012: 3
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- primary biliary cirrhosis, intrahepatic bile ducts, bile duct destruction, periductal fibrosis, portal tract, histomorphometry, disease stage
- MeSH terms
- Adult, Aged, Arteries, Bile Ducts, Intrahepatic, Female, Humans, Hyperplasia, Japan, Liver, Liver Circulation, Liver Cirrhosis, Biliary, Male, Middle Aged
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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