Effect of colonic perfusion with sulfated and nonsulfated bile acids on mucosal structure and function in the rat

Breuer, Norbert F.; Rampton, David S.; Tammar, Anthony; Murphy, Gerard M.; Dowling, R.Hermon

doi:10.1016/0016-5085(83)90199-3

Cited by 61Drug Transport and Resistance MechanismsGastrointestinal motility and disordersIon Transport and Channel Regulation

Effect of colonic perfusion with sulfated and nonsulfated bile acids on mucosal structure and function in the rat

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Breuer, Norbert F., Rampton, David S., Tammar, Anthony, Murphy, Gerard M., Dowling, R.Hermon·1983·Gastroenterology

DOI 10.1016/0016-5085(83)90199-3

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The gut microbiota may influence functional constipation through its impact on bile acid sulfation, in which colonic bacterial bile salt sulfatase may desulfate bile acids, empowering their effect to stimulate colonic secretion and transit and consequently improve colonic fluid transport.
“Another mechanism for the gut microbiota to influence FC is through its impact on BA sulfation, which abolishes the effect of the BAs on fluid transport [ 51 , 52 ]. BA sulfation likely occurred in hepatocytes, while colonic bacterial bile salt sulfatase may desulfate BA, empowering its effect to stimulate colonic secretion and transit, and consequently improve colonic fluid transport [ 53 ].”
From Role of gut microbiota in functional constipation (2021) · cites this paper as [52]

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Authors: Breuer, N. F., Rampton, D. S., Tammar, A., Murphy, G. M., & Dowling, R. H.
Affiliations: University College Hospital (GB)
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 1983-05
Volume: 84
Issue: 5
Pages: 969-977
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1016/0016-5085(83)90199-3
OpenAlex: W4300228569
Cited by: 61
References: 39
Citations by year: 2025: 1 · 2024: 1 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 2 · 2017: 2 · 2016: 2 · 2015: 4 · 2013: 3 · 2012: 2
FWCI: 1.29
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
PubMed
Funders: Wellcome Trust
Deutsche Forschungsgemeinschaft
Topics: Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords: sulfated bile acids, colonic mucosa, deoxycholic acid, chenodeoxycholic acid, cholic acid, water and electrolyte transport, sodium uptake, mucosal injury
MeSH terms: Animals, Bile Acids and Salts, Biological Transport, Chenodeoxycholic Acid, Cholic Acids, Colon, Deoxycholic Acid, Diarrhea, DNA, Intestinal Mucosa, Ion Channels, Mucus, Perfusion, Proteins, Water-Electrolyte Balance, Cholic Acid, Rats

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Effect of colonic perfusion with sulfated and nonsulfated bile acids on mucosal structure and function in the rat

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