Leaky gut: mechanisms, measurement and clinical implications in humans

Intestinal mucosal barrier function in health and disease

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Cytokines sing the blues: inflammation and the pathogenesis of depression

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Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers

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Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

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Gut microbiota are related to Parkinson's disease and clinical phenotype

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Intestinal permeability – a new target for disease prevention and therapy

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Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

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Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection

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Control of pathogens and pathobionts by the gut microbiota

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The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

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The intestinal epithelial barrier: a therapeutic target?

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Colonic bacterial composition in Parkinson's disease

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Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

Kelly, J. R., Kennedy, P. J., Cryan, J. F., Dinan, T. G., Clarke, G., & Hyland, N. P. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00392 · Cited by 1,110 · see citing works

Immunological aspects of intestinal mucus and mucins

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Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease

Forsyth, C. B., Shannon, K. M., Kordower, J. H., Voigt, R. M., Shaikh, M., Jaglin, J. A., Estes, J. D., Dodiya, H. B., & Keshavarzian, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028032 · Cited by 974 · see citing works

Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

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Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions

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Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives

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Bile Salts and Glycine as Cogerminants for <i>Clostridium difficile</i> Spores

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Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut

Michielan, A., & D’Incà, R. (2015) · Mediators of Inflammation · doi:10.1155/2015/628157 · Cited by 709 · see citing works

The composition of the gut microbiota shapes the colon mucus barrier

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Alterations in intestinal permeability

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Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism

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The Potential of Gut Commensals in Reinforcing Intestinal Barrier Function and Alleviating Inflammation

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Mechanisms of Damage to the Gastrointestinal Tract From Nonsteroidal Anti-Inflammatory Drugs

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Role of Inflammation in Muscle Homeostasis and Myogenesis

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Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression

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Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease

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Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity

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The Human Microbiome and Obesity: Moving beyond Associations

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Gut microbiota: A player in aging and a target for anti-aging intervention

Vaiserman, A. M., Koliada, A. K., & Marotta, F. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.01.001 · Cited by 465 · see citing works

A Controlled Trial of Gluten-Free Diet in Patients With Irritable Bowel Syndrome-Diarrhea: Effects on Bowel Frequency and Intestinal Function

Vázquez‐Roque, M. I., Camilleri, M., Smyrk, T. C., Murray, J. A., Marietta, E. V., O’Neill, J., Carlson, P., Lamsam, J. L., Janzow, D., Eckert, D. J., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.049 · Cited by 454 · see citing works

Increased IgA and IgM responses against gut commensals in chronic depression: Further evidence for increased bacterial translocation or leaky gut

Maes, M., Kubera, M., Leunis, J.-C., & Berk, M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.02.023 · Cited by 446 · see citing works

Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal cancers: exploring a common ground hypothesis

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Irritable Bowel Syndrome: Methods, Mechanisms, and Pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome

Camilleri, M., Lasch, K. L., & Zhou, W. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00155.2012 · Cited by 397 · see citing works

Changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiological stress

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Intestinal Permeability Defects: Is It Time to Treat?

Odenwald, M. A., & Turner, J. R. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.07.001 · Cited by 366 · see citing works

Genetic basis for increased intestinal permeability in families with Crohn’s disease: role of CARD15 3020insC mutation?

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Probiotic Bifidobacterium strains and galactooligosaccharides improve intestinal barrier function in obese adults but show no synergism when used together as synbiotics

Krumbeck, J. A., Rasmussen, H. E., Hutkins, R. W., Clarke, J., Shawron, K., Keshavarzian, A., & Walter, J. (2018) · Microbiome · doi:10.1186/s40168-018-0494-4 · Cited by 342 · see citing works

Confocal Endomicroscopy Shows Food-Associated Changes in the Intestinal Mucosa of Patients With Irritable Bowel Syndrome

Fritscher-Ravens, A., Schuppan, D., Ellrichmann, M., Schoch, S., Röcken, C., Brasch, J., Bethge, J., Böttner, M., Klose, J., & Milla, P. J. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.07.046 · Cited by 329 · see citing works

Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)

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Gut microbiota as a source of novel antimicrobials

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Structural alterations of the intestinal epithelial barrier in Parkinson’s disease

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The intestinal barrier and its regulation by neuroimmune factors: Intestinal barrier and neuroimmune regulation

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Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability

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Translocation of Crohn's disease Escherichia coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers

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A PERSISTENT DEFECT IN INTESTINAL PERMEABILITY IN COELIAC DISEASE DEMONSTRATED BY A 51Cr-LABELLED EDTA ABSORPTION TEST

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Bifidobacteria Stabilize Claudins at Tight Junctions and Prevent Intestinal Barrier Dysfunction in Mouse Necrotizing Enterocolitis

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Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation

Summa, K. C., Voigt, R. M., Forsyth, C. B., Shaikh, M. W., Cavanaugh, K. E., Tang, Y., Vitaterna, M. H., Song, S., Turek, F. W., & Keshavarzian, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067102 · Cited by 254 · see citing works

Measurements of Intestinal Permeability Using Low Molecular Weight Polyethylene Glycols (PEG 400)

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Gut inflammation and dysbiosis in human motor neuron disease

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Intra-Articular Cytokine Levels in Adolescent Patients after Anterior Cruciate Ligament Tear

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Intestinal Permeability Test As A Predictor of Clinical Course in Crohn's Disease

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Overview and systematic review of studies of microbiome in schizophrenia and bipolar disorder

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Evaluation of the Microbial Diversity in Amyotrophic Lateral Sclerosis Using High-Throughput Sequencing

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The effect of supplemental enteral glutamine on plasma levels, gut function, and outcome in severe burns: a randomized, double‐blind, controlled clinical trial

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Gut permeability and food allergies

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Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome

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Intestinal permeability and inflammation in patients on NSAIDs

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Age-associated modifications of intestinal permeability and innate immunity in human small intestine.

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Esophageal Microbiome in Eosinophilic Esophagitis

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Small intestinal bacterial overgrowth and toll‐like receptor signaling in patients with non‐alcoholic fatty liver disease

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Effects of enteral supplementation with glutamine granules on intestinal mucosal barrier function in severe burned patients

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Intestinal Permeability Biomarker Zonulin is Elevated in Healthy Aging

Qi, Y., Goel, R., Kim, S., Richards, E. M., Carter, C. S., Pepine, C. J., Raizada, M. K., & Buford, T. W. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.05.018 · Cited by 165 · see citing works

The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes

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Inflammation-associated microbiota in pediatric eosinophilic esophagitis

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Urine sugars for in vivo gut permeability: validation and comparisons in irritable bowel syndrome-diarrhea and controls

Rao, A. S., Camilleri, M., Eckert, D. J., Busciglio, I. A., Burton, D. D., Ryks, M. D., Wong, B. S., Lamsam, J. L., Singh, R., & Zinsmeister, A. R. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00168.2011 · Cited by 145 · see citing works

Gut Microbiota Richness and Composition and Dietary Intake of Overweight Pregnant Women Are Related to Serum Zonulin Concentration, a Marker for Intestinal Permeability

Mokkala, K., Röytiö, H., Munukka, E., Pietilä, S., Ekblad, U., Rönnemaa, T., Eerola, E., Laiho, A., & Laitinen, K. (2016) · Journal of Nutrition · doi:10.3945/jn.116.235358 · Cited by 145 · see citing works

Intestinal permeability in patients with adverse reactions to food

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Association Between Exercise-Induced Hyperthermia and Intestinal Permeability: A Systematic Review

Pires, W., Veneroso, C. E., Wanner, S. P., Pacheco, D. A. S., Vaz, G. C., Amorim, F. T., Tonoli, C., Soares, D. D., & Coimbra, C. C. (2016) · Sports Medicine · doi:10.1007/s40279-016-0654-2 · Cited by 141 · see citing works

Leaky gut – concept or clinical entity?

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Bacterial translocation in patients with liver cirrhosis: physiology, clinical consequences, and practical implications

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Synthetic surfactant food additives can cause intestinal barrier dysfunction

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Inulin-enriched pasta improves intestinal permeability and modifies the circulating levels of zonulin and glucagon-like peptide 2 in healthy young volunteers

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Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes

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Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

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Psyllium fiber reduces abdominal pain in children with irritable bowel syndrome in a randomized, double-blind trial

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Effects of neurotransmitters, gut hormones, and inflammatory mediators on mucus discharge in rat colon

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Acute Exposure to Commonly Ingested Emulsifiers Alters Intestinal Mucus Structure and Transport Properties

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Intestinal epithelial cell apoptosis and loss of barrier function in the setting of altered microbiota with enteral nutrient deprivation

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