The DOI matches its Crossref record; 14 of the 15 references it cites were found in a registry or an index.
Circadian variation in gastric emptying of meals in humans
Abstract
Circadian changes in drug absorption have been documented for several orally administered drugs in humans. To determine whether gastric emptying could account for these changes, morning (8 AM) and evening (8 PM) gastric emptying rates were measured in 16 healthy male subjects synchronized with diurnal activity and nocturnal rest. Gastric emptying half-times for the evening meal were significantly (p less than 0.001) longer for solids but not liquids when compared with morning emptying half-times. The increase in evening meal emptying time (53.6%) may account for the evening delay in reaching peak plasma concentrations documented for several drugs.
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In the citing paper
“Accordingly, the rate of gastric emptying for solids was reported to be higher in the evening compared to the morning [30].”
From Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption (2013) · cites this paper as [30]
In the citing paper
“The arguments in favor of limiting and/or avoiding food intake late in the night are supported by data demonstrating diurnal variations in glucose tolerance [1], gastric emptying [2], resting energy expenditure [3].”
From The Health Impact of Nighttime Eating: Old and New Perspectives (2015) · cites this paper as [2]
Citations
Cites
Gastric emptying in patients with gastroesophageal reflux
McCallum, R. W., Berkowitz, D. M., & Lerner, E. (1981) · Gastroenterology · doi:10.1016/0016-5085(81)90716-2 · Cited by 408
Circadian Changes of Drug Disposition in Man
Reinberg, A., & Smolensky, M. H. (1982) · Clinical Pharmacokinetics · doi:10.2165/00003088-198207050-00002 · Cited by 220
Gastric emptying of varying meal weight and composition in man
Moore, J. G., Christian, P. E., & Coleman, R. E. (1981) · Digestive Diseases and Sciences · doi:10.1007/bf01307971 · Cited by 217
Self-citationTechniques and errors in scintigraphic measurements of gastric emptying.
Tothill, P., McLoughlin, G. P., & Heading, R. C. (1978) · PubMed · Cited by 168
Circadian variation in the propagation velocity of the migrating motor complex
Kumar, D., Wingate, D. L., & Ruckebusch, Y. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90696-7 · Cited by 135
Pathogenesis of esophagitis in patients with gastroesophageal reflux.
Little, A. G., DeMeester, T. R., Kirchner, P. T., O’Sullivan, G. C., & Skinner, D. B. (1980) · PubMed · Cited by 130
Circadian changes in the bioavailability and effects of indomethacin in healthy subjects
Clench, J., Reinberg, A., Dziewanowska, Z. E., Ghata, J., & Smolensky, M. H. (1981) · European Journal of Clinical Pharmacology · doi:10.1007/bf00615406 · Cited by 113
Effect of prolonged exercise on the passage of a solid meal through the stomach and small intestine.
Cammack, J., Read, N. W., Cann, P., Greenwood, B., & Holgate, A. (1982) · Gut · doi:10.1136/gut.23.11.957 · Cited by 107
Radiation dose estimates for oral agents used in upper gastrointestinal disease.
Siegel, J. A., Wu, R. K., KNIGHT, L. C., Zelac, R. E., Stern, H. S., & Malmud, L. S. (1983) · PubMed · Cited by 96
Gastric emptying measurements: delayed and complex emptying patterns without appropriate correction.
Moore, J. G., Christian, P. E., Taylor, A. T., & Alazraki, N. P. (1985) · PubMed · Cited by 52
Self-citation
Research works printed but not linked: 1
- Reinberg, 1986, Clinical chronokinetic changes in a sustained release preparation of ketoprofen (SRK), Ann Rev Chronopharmacol, 3, 317
Cited by
Sorted by citations
Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures
Potter, G. D., Skene, D. J., Arendt, J., Cade, J. E., Grant, P. J., & Hardie, L. J. (2016) · Endocrine Reviews · doi:10.1210/er.2016-1083 · Cited by 781
Circadian Variation in Sports Performance
Atkinson, G., & Reilly, T. (1996) · Sports Medicine · doi:10.2165/00007256-199621040-00005 · Cited by 576
Gut instincts: Explorations in intestinal physiology and drug delivery
McConnell, E. L., Fadda, H. M., & Basit, A. W. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.05.012 · Cited by 442
Pathophysiology of Gastroesophageal Reflux Disease
Tack, J. F., & Pandolfino, J. E. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.09.047 · Cited by 430
Timing of food intake and obesity: a novel association
Garaulet, M., & Gómez-Abellán, P. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.01.001 · Cited by 362
Metadata
- Authors
- Goo, R. H., Moore, J. G., Greenberg, E., & Alazraki, N. P.
- Affiliations
- United States Department of Veterans Affairs (US)
- ORCID
- Moore, J.G.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1987-09
- Volume
- 93
- Issue
- 3
- Pages
- 515-518
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1472243025
- Cited by
- 345
- References
- 15
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 9 · 2023: 12 · 2022: 10 · 2021: 14 · 2020: 33 · 2019: 9 · 2018: 11 · 2017: 15 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 11 · 2012: 10
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- circadian rhythm, gastric emptying, meal timing, drug absorption, oral bioavailability, food effect on absorption
- MeSH terms
- Adult, Circadian Rhythm, Food, Gastric Emptying, Humans, Male
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