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Circadian variation in gastric emptying of meals in humans
Abstract
Circadian changes in drug absorption have been documented for several orally administered drugs in humans. To determine whether gastric emptying could account for these changes, morning (8 AM) and evening (8 PM) gastric emptying rates were measured in 16 healthy male subjects synchronized with diurnal activity and nocturnal rest. Gastric emptying half-times for the evening meal were significantly (p less than 0.001) longer for solids but not liquids when compared with morning emptying half-times. The increase in evening meal emptying time (53.6%) may account for the evening delay in reaching peak plasma concentrations documented for several drugs.
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“Accordingly, the rate of gastric emptying for solids was reported to be higher in the evening compared to the morning [30].”
From Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption (2013) · cites this paper as [30]
In the citing paper
“The arguments in favor of limiting and/or avoiding food intake late in the night are supported by data demonstrating diurnal variations in glucose tolerance [1], gastric emptying [2], resting energy expenditure [3].”
From The Health Impact of Nighttime Eating: Old and New Perspectives (2015) · cites this paper as [2]
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Metadata
- Authors
- Goo, R. H., Moore, J. G., Greenberg, E., & Alazraki, N. P.
- Affiliations
- United States Department of Veterans Affairs (US)
- ORCID
- Moore, J.G.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1987-09
- Volume
- 93
- Issue
- 3
- Pages
- 515-518
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1472243025
- Cited by
- 345
- References
- 15
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 9 · 2023: 12 · 2022: 10 · 2021: 14 · 2020: 33 · 2019: 9 · 2018: 11 · 2017: 15 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 11 · 2012: 10
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- circadian rhythm, gastric emptying, meal timing, drug absorption, oral bioavailability, food effect on absorption
- MeSH terms
- Adult, Circadian Rhythm, Food, Gastric Emptying, Humans, Male
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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