The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Enteric neuronal autoantibodies in pseudoobstruction with small-cell lung carcinoma
Abstract
Severe gastrointestinal dysmotility is a newly recognized paraneoplastic syndrome that occurs with small-cell lung carcinoma. Thirty-four patients with small-cell carcinoma, of whom 5 had chronic intestinal pseudoobstruction and 29 had no digestive symptoms, were studied serologically. Four of the 5 patients with gut dysmotility had immunoglobulin G antibodies reactive with neurons of the myenteric and submucosal plexuses of jejunum and stomach in an indirect immunofluorescence assay. Antibodies of this type were not found in any of the 29 patients who had no gut dysmotility, nor were they found in patients with chronic idiopathic intestinal pseudoobstruction (n = 8), ovarian cancer (n = 20), or epilepsy (n = 4) or in normal subjects (n = 9). In 4 of the patients with paraneoplastic pseudoobstruction, antibodies in highly diluted serum (1:4000-1:8000) bound selectively to nuclei and cytoplasm of neuronal elements in the gut. This novel autoantibody activity suggests that intestinal pseudoobstruction occurring in patients with small-cell carcinoma may have an autoimmune basis. From a clinical standpoint, serological testing offers a simple means for determining which patients with gut dysmotility syndromes may have associated small-cell carcinoma, thereby enabling earlier diagnosis and treatment of the tumor.
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“Circulating IgG autoantibodies such as ANNA-1 (anti-Hu), directed against neuronal nuclear antigens, support an immune attack on the enteric nervous system in paraneoplastic dysmotility (Lennon et al., 1991).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Lennon et al., 1991
Citations
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Metadata
- Authors
- Lennon, V. A., Sas, D. F., Busk, M. F., Scheithauer, B., Malagelada, J.-R., Camilleri, M., & Miller, L. J.
- Affiliations
- Mayo Clinic (US)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1991-01
- Volume
- 100
- Issue
- 1
- Pages
- 137-142
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1609538723
- Cited by
- 250
- References
- 33
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 7 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 9 · 2013: 6 · 2012: 7
- FWCI
- 8.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca037343-11, 5p30dk034988-05)
- National Cancer Institute (CA-37343)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 34988, DK-32878)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Keywords
- small cell lung cancer, gastrointestinal motility disorders, paraneoplastic syndrome, myenteric plexus, submucosal plexus, serological diagnosis, indirect immunofluorescence
- MeSH terms
- Aged, Autoantibodies, Chronic Disease, Female, Humans, Intestinal Pseudo-Obstruction, Lung Neoplasms, Male, Middle Aged, Myenteric Plexus, Neurons, Paraneoplastic Syndromes, Carcinoma, Small Cell
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