The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Enteric neuronal autoantibodies in pseudoobstruction with small-cell lung carcinoma
Abstract
Severe gastrointestinal dysmotility is a newly recognized paraneoplastic syndrome that occurs with small-cell lung carcinoma. Thirty-four patients with small-cell carcinoma, of whom 5 had chronic intestinal pseudoobstruction and 29 had no digestive symptoms, were studied serologically. Four of the 5 patients with gut dysmotility had immunoglobulin G antibodies reactive with neurons of the myenteric and submucosal plexuses of jejunum and stomach in an indirect immunofluorescence assay. Antibodies of this type were not found in any of the 29 patients who had no gut dysmotility, nor were they found in patients with chronic idiopathic intestinal pseudoobstruction (n = 8), ovarian cancer (n = 20), or epilepsy (n = 4) or in normal subjects (n = 9). In 4 of the patients with paraneoplastic pseudoobstruction, antibodies in highly diluted serum (1:4000-1:8000) bound selectively to nuclei and cytoplasm of neuronal elements in the gut. This novel autoantibody activity suggests that intestinal pseudoobstruction occurring in patients with small-cell carcinoma may have an autoimmune basis. From a clinical standpoint, serological testing offers a simple means for determining which patients with gut dysmotility syndromes may have associated small-cell carcinoma, thereby enabling earlier diagnosis and treatment of the tumor.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Circulating IgG autoantibodies such as ANNA-1 (anti-Hu), directed against neuronal nuclear antigens, support an immune attack on the enteric nervous system in paraneoplastic dysmotility (Lennon et al., 1991).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Lennon et al., 1991
Citations
Cites
Neuronal antinuclear antibody in sensory neuronopathy from lung cancer
Graus, F., Cordon‐Cardo, C., & Posner, J. B. (1985) · Neurology · doi:10.1212/wnl.35.4.538 · Cited by 367
AUTOIMMUNE AETIOLOGY FOR MYASTHENIC (EATON-LAMBERT) SYNDROME
Lang, B., Wray, D., Newsom–Davis, J., Vincent, A. C., & Murray, N. M. F. (1981) · The Lancet · doi:10.1016/s0140-6736(81)90474-8 · Cited by 366
Chronic idiopathic intestinal pseudo-obstruction: clinical and intestinal manometric findings.
Stanghellini, V., Camilleri, M., & Malagelada, J. (1987) · Gut · doi:10.1136/gut.28.1.5 · Cited by 282
Self-citationVellenga, E., Imhoff, G. W. V., & Aarnoudse, J. G. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90209-x · Cited by 265
Paraneoplastic myasthenic syndrome IgG inhibits 45Ca2+ flux in a human small cell carcinoma line
Roberts, A., Perera, S., Lang, B., Vincent, A. C., & Newsom–Davis, J. (1985) · Nature · doi:10.1038/317737a0 · Cited by 245
Pathology of neuromuscular disorders of the small intestine and colon
Krishnamurthy, S., & Schuffler, M. D. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90926-7 · Cited by 235
ISLET-CELL ANTIBODIES IN JUVENILE DIABETES MELLITUS OF RECENT ONSET
Lendrum, R., Walker, G., & Gamble, D. R. (1975) · The Lancet · doi:10.1016/s0140-6736(75)91683-9 · Cited by 222
Intestinal Pseudo-Obstruction as the Presenting Manifestation of Small-Cell Carcinoma of the Lung
Schuffler, M. D., BAIRD, H. W., FLEMING, C. R., BELL, C. E., BOULDIN, T. W., Malagelada, J. R., McGILL, D. B., LeBAUER, S. M., ABRAMS, M., & LOVE, J. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-98-2-129 · Cited by 157
Self-citationParaneoplastic visceral neuropathy as a cause of severe gastrointestinal motor dysfunction
Chinn, J. S., & Schuffler, M. D. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90362-9 · Cited by 140
Manometric Diagnosis of Gastrointestinal Motility Disorders
Christensen, J. C. (1986) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62645-7 · Cited by 138
Research works printed but not linked: 2
- Lhermitte, 1980, Paralysis of digestive tract with lesions of myenteric plexus: a new paraneoplastic syndrome, Rev Neurol (Paris), 136, 825
- Sonsino, 1984, Intestinal pseudo-obstruction related to cytomegalovirus infection of the myenteric plexus (letter), N Engl J Med, 196, 311
Cited by
Sorted by citations
Goyal, R. K., & Hirano, I. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604253341707 · Cited by 774
Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies
Vernino, S., Low, P. A., Fealey, R. D., Stewart, J. D., Farrugia, G., & Lennon, V. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009213431204 · Cited by 674
Self-citationLucchinetti, C. F., Kimmel, D. W., & Lennon, V. A. (1998) · Neurology · doi:10.1212/wnl.50.3.652 · Cited by 499
Self-citationInflammatory neuropathies of the enteric nervous system☆
GIORGIO, R. D., Guerrini, S., Barbara, G., Stanghellini, V., Ponti, F. D., Corinaldesi, R., Moses, P. L., Sharkey, K. A., & Mawe, G. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.02.024 · Cited by 303
Autonomic peripheral neuropathy
Freeman, R. L. (2005) · The Lancet · doi:10.1016/s0140-6736(05)74815-7 · Cited by 268
Metadata
- Authors
- Lennon, V. A., Sas, D. F., Busk, M. F., Scheithauer, B., Malagelada, J.-R., Camilleri, M., & Miller, L. J.
- Affiliations
- Mayo Clinic (US)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1991-01
- Volume
- 100
- Issue
- 1
- Pages
- 137-142
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1609538723
- Cited by
- 250
- References
- 33
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 7 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 9 · 2013: 6 · 2012: 7
- FWCI
- 8.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca037343-11, 5p30dk034988-05)
- National Cancer Institute (CA-37343)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 34988, DK-32878)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Keywords
- small cell lung cancer, gastrointestinal motility disorders, paraneoplastic syndrome, myenteric plexus, submucosal plexus, serological diagnosis, indirect immunofluorescence
- MeSH terms
- Aged, Autoantibodies, Chronic Disease, Female, Humans, Intestinal Pseudo-Obstruction, Lung Neoplasms, Male, Middle Aged, Myenteric Plexus, Neurons, Paraneoplastic Syndromes, Carcinoma, Small Cell
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
