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Cited by 250Autoimmune Neurological Disorders and TreatmentsGastrointestinal motility and disordersPeripheral Neuropathies and Disorders

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Enteric neuronal autoantibodies in pseudoobstruction with small-cell lung carcinoma

Lennon, Vanda A., Sas, Daryl F., Busk, Michael F., Scheithauer, Bernd, Malagelada, Juan-R., Camilleri, Michael, Miller, Laurence J.·1991·Gastroenterology
DOI 10.1016/0016-5085(91)90593-a
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Abstract

Severe gastrointestinal dysmotility is a newly recognized paraneoplastic syndrome that occurs with small-cell lung carcinoma. Thirty-four patients with small-cell carcinoma, of whom 5 had chronic intestinal pseudoobstruction and 29 had no digestive symptoms, were studied serologically. Four of the 5 patients with gut dysmotility had immunoglobulin G antibodies reactive with neurons of the myenteric and submucosal plexuses of jejunum and stomach in an indirect immunofluorescence assay. Antibodies of this type were not found in any of the 29 patients who had no gut dysmotility, nor were they found in patients with chronic idiopathic intestinal pseudoobstruction (n = 8), ovarian cancer (n = 20), or epilepsy (n = 4) or in normal subjects (n = 9). In 4 of the patients with paraneoplastic pseudoobstruction, antibodies in highly diluted serum (1:4000-1:8000) bound selectively to nuclei and cytoplasm of neuronal elements in the gut. This novel autoantibody activity suggests that intestinal pseudoobstruction occurring in patients with small-cell carcinoma may have an autoimmune basis. From a clinical standpoint, serological testing offers a simple means for determining which patients with gut dysmotility syndromes may have associated small-cell carcinoma, thereby enabling earlier diagnosis and treatment of the tumor.

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Crossref · 10.1016/0016-5085(91)90593-a

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33 of 33 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 2

  1. Lhermitte, 1980, Paralysis of digestive tract with lesions of myenteric plexus: a new paraneoplastic syndrome, Rev Neurol (Paris), 136, 825
  2. Sonsino, 1984, Intestinal pseudo-obstruction related to cytomegalovirus infection of the myenteric plexus (letter), N Engl J Med, 196, 311

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Metadata

Authors
Lennon, V. A., Sas, D. F., Busk, M. F., Scheithauer, B., Malagelada, J.-R., Camilleri, M., & Miller, L. J.
Affiliations
Mayo Clinic (US)
ORCID
Venue
Gastroenterology
Publisher
Elsevier BV
Published
1991-01
Volume
100
Issue
1
Pages
137-142
ISSN
0016-5085 (ISSN-L)
DOI
10.1016/0016-5085(91)90593-a
OpenAlex
W1609538723
Cited by
250
References
33
Citations by year
2026: 3 · 2025: 2 · 2024: 7 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 9 · 2013: 6 · 2012: 7
FWCI
8.06
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ca037343-11, 5p30dk034988-05)
  • National Cancer Institute (CA-37343)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 34988, DK-32878)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Autoimmune Neurological Disorders and Treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
Keywords
small cell lung cancer, gastrointestinal motility disorders, paraneoplastic syndrome, myenteric plexus, submucosal plexus, serological diagnosis, indirect immunofluorescence
MeSH terms
Aged, Autoantibodies, Chronic Disease, Female, Humans, Intestinal Pseudo-Obstruction, Lung Neoplasms, Male, Middle Aged, Myenteric Plexus, Neurons, Paraneoplastic Syndromes, Carcinoma, Small Cell

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