Cited by 649Gastrointestinal motility and disordersInfant Health and DevelopmentGut microbiota and health

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Epidemiology of colonic symptoms and the irritable bowel syndrome

Talley, Nicholas J., Zinsmeister, Alan R., van Dyke, Carol, Melton, L.Joseph·1991·Gastroenterology

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Abstract

Functional gastrointestinal disease is believed to be very common, but reports of its prevalence have not usually evaluated random community samples, and validated questionnaires have not been used to elicit symptoms. The prevalence of specific colonic symptoms and the irritable bowel syndrome among representative middle-aged whites was determined from a defined population, and the impact of these symptoms on presentation for medical care was measured. An age- and sex-stratified random sample of 1021 residents of Olmsted County, Minnesota, aged 30-64 years, was obtained. All subjects were mailed a valid self-report questionnaire that identified gastrointestinal symptoms and functional gastrointestinal disorders. The response rate was 82% (n = 835). The age- and sex-adjusted prevalence of abdominal pain (more than six times in the prior year) was 26.2 per 100 (95% confidence interval, 23.1-29.2). The prevalence of chronic constipation (hard stools and straining and/or less than 3 stools per week greater than 25% of the time) was 17.4 (95% confidence interval, 14.8-20.0), whereas the prevalence of chronic diarrhea (loose watery stools, and/or greater than 3 stools per day greater than 25% of the time) was 17.9 (95% confidence interval, 15.3-20.5). The prevalence of abdominal pain and disturbed defecation was similar in women and men, except that infrequent defecation and straining at stool were more common in women. Using the Manning symptom criteria to identify irritable bowel syndrome (greater than or equal to 2 of 6 symptoms in those with abdominal pain more than six times in the prior year), the prevalence of irritable bowel syndrome was 17.0 per 100 (95% confidence interval, 14.4-19.6). Overall, 71 persons (9%) reported visiting a physician for abdominal pain or disturbed defecation in the prior year; a subset of variables related to pain severity were the best predictors of health care seeking after adjustment for age and gender. However, these accounted for only 22% of the log likelihood. In conclusion, more than one third of an unselected middle-aged population reported chronic abdominal pain or disturbed defecation, and more than one in six had symptoms compatible with the irritable bowel syndrome. Only a minority had presented for medical evaluation; moreover, the characteristics of the abdominal complaints did not explain the seeking of health care in most cases.

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Chitkara, D. K., Talley, N. J., Schleck, C. D., Zinsmeister, A. R., Shah, N. D., & Locke, G. R. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802555975 · Cited by 26
“The strengths of this study are that the participants were drawn from a population-based sample, and it was administered as a validated assessment of GI symptoms that have been previously utilized in other epidemiologic assessments of functional GI symptoms [21,22].”
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Irritable Bowel Syndrome: Update on Pathogenesis and Management
Alaradi, O., & Barkin, J. S. (2002) · Medical Principles and Practice · doi:10.1159/000048654 · Cited by 25
Why do functional gastrointestinal disorders come and go?
Talley, N. J. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02087407 · Cited by 26
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Laxative Use in the Community: A Literature Review
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“An extremely wide range was found for both chronic [9,14,22,23,29,36,38,41,42,45] and any constipation [5,18,19,21,36,37,40,43,46] (Tables 2 and 3).”
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A Monoclonal Anti–Calcitonin Gene-Related Peptide Antibody Decreases Stress-Induced Colonic Hypersensitivity
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“Specifically, childhood adversity increases the likelihood of developing adult GI disorders, such as IBS (Whitehead et al., 1990; Talley et al., 1991).”
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Endometriosis, need for a multidisciplinary clinical setting: the internist’s point of view
Montalto, M., Santoro, L., D’Onofrio, F., Gallo, A., Campo, S., Campo, V., Gasbarrini, A., & Gasbarrini, A. (2010) · Internal and Emergency Medicine · doi:10.1007/s11739-010-0404-7 · Cited by 25
“The clinical features of IBS, mainly pain or abdominal discomfort and alvus disorders, may often overlap with the clinical pattern of endometriosis [26].”
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“Depending on different criteria, the prevalence of irritable bowel syndrome (IBS) in the Western population has been estimated at 12 17% [1,2].”
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Multiple food hypersensitivity as a cause of refractory chronic constipation in adults
Carroccio, A., Prima, L. D., Iacono, G., Florena, A. M., D’Arpa, F., Sciumè, C., Cefalu, A. B., Noto, D., & Averna, M. R. (2006) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520500367400 · Cited by 25
“However, the severity of abdominal pain (nocturnal and sleep-disturbing) observed in our patients is uncommon in IBS, and previous treatments were not effective (data not shown).”
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“Irritable bowel syndrome (IBS) is one of the most common functional disorders of the gastrointestinal tract, with major symptoms such as abdominal discomfort or pain accompanied by constipation or diarrhea (Talley et al., 1991; Drossman et al., 1993).”
BackgroundMethod
The effects of the 5‐HT3 antagonist, alosetron, on brain serotonin synthesis in patients with irritable bowel syndrome
Nakai, A., Dikšić, M., Kumakura, Y., D'Souza, D. L., & Kersey, K. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00615.x · Cited by 24
Disturbances in large bowel motility
Spiller, R. E. (1999) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.1999.0035 · Cited by 24
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Usai, P., Manca, R., Lai, M. A., Russo, L., Boi, M. F., Ibba, I., Giolitto, G., & Cuomo, R. (2010) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2010.05.009 · Cited by 23
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“FGIDs are common both in general and clinical populations.(3-5) Although they are usually not life threatening, they may persist in the majority of those affected, resulting in significant distress in social, family and academic lives of the sub-”
Effect of several recruitment strategies on response rates at baseline in a prospective cohort investigation The Olmsted county study of urinary symptoms and health status among men
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Is irritable bowel syndrome more likely to be persistent in those with relatives who suffer from gastrointestinal symptoms? A population‐based study at three time points
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Choung, R. S., Locke, G. R., Schleck, C. D., Zinsmeister, A. R., & Talley, N. J. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12082 · Cited by 21
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Romero, Y., Thistle, J. L., Longstreth, G. F., Harmsen, S. W., Schleck, C. D., Zinsmeister, A. R., Pardi, D. S., Zein, C. O., Dyke, C. T. V., Arora, A. S., et al. (2003) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(03)00148-5 · Cited by 21
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Linaclotide inhibits colonic and urinary bladder hypersensitivity in adult female rats following unpredictable neonatal stress
Ligon, C. O., Mohammadi, E., Ge, P., Hannig, G., Higgins, C. S., & Meerveld, B. G. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13375 · Cited by 20

Authors: Talley, N. J., Zinsmeister, A. R., van Dyke, C., & Melton, L. J.
Affiliations: Mayo Clinic (US)
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 1991-10
Volume: 101
Issue: 4
Pages: 927-934
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1016/0016-5085(91)90717-y
OpenAlex: W1606920119
Cited by: 648
References: 33
Citations by year: 2026: 2 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 10 · 2020: 7 · 2019: 4 · 2018: 9 · 2017: 10 · 2016: 8 · 2015: 19 · 2014: 26 · 2013: 16 · 2012: 25
FWCI: 17.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p30dk034988-05)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 34988)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR030582, AR30582)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: irritable bowel syndrome, functional gastrointestinal disorders, prevalence, abdominal pain, chronic constipation, chronic diarrhea, health-seeking behavior, middle-aged adults, sex differences, Olmsted County, Minnesota, community survey, unmet care needs
MeSH terms: Colonic Diseases, Functional, Constipation, Diarrhea, Female, Humans, Male, Middle Aged, Minnesota, Patient Acceptance of Health Care, Surveys and Questionnaires, Abdominal Pain, Prevalence

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Epidemiology of colonic symptoms and the irritable bowel syndrome

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