Cited by 649Gastrointestinal motility and disordersInfant Health and DevelopmentGut microbiota and health

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Epidemiology of colonic symptoms and the irritable bowel syndrome

Talley, Nicholas J., Zinsmeister, Alan R., van Dyke, Carol, Melton, L.Joseph·1991·Gastroenterology

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Abstract

Functional gastrointestinal disease is believed to be very common, but reports of its prevalence have not usually evaluated random community samples, and validated questionnaires have not been used to elicit symptoms. The prevalence of specific colonic symptoms and the irritable bowel syndrome among representative middle-aged whites was determined from a defined population, and the impact of these symptoms on presentation for medical care was measured. An age- and sex-stratified random sample of 1021 residents of Olmsted County, Minnesota, aged 30-64 years, was obtained. All subjects were mailed a valid self-report questionnaire that identified gastrointestinal symptoms and functional gastrointestinal disorders. The response rate was 82% (n = 835). The age- and sex-adjusted prevalence of abdominal pain (more than six times in the prior year) was 26.2 per 100 (95% confidence interval, 23.1-29.2). The prevalence of chronic constipation (hard stools and straining and/or less than 3 stools per week greater than 25% of the time) was 17.4 (95% confidence interval, 14.8-20.0), whereas the prevalence of chronic diarrhea (loose watery stools, and/or greater than 3 stools per day greater than 25% of the time) was 17.9 (95% confidence interval, 15.3-20.5). The prevalence of abdominal pain and disturbed defecation was similar in women and men, except that infrequent defecation and straining at stool were more common in women. Using the Manning symptom criteria to identify irritable bowel syndrome (greater than or equal to 2 of 6 symptoms in those with abdominal pain more than six times in the prior year), the prevalence of irritable bowel syndrome was 17.0 per 100 (95% confidence interval, 14.4-19.6). Overall, 71 persons (9%) reported visiting a physician for abdominal pain or disturbed defecation in the prior year; a subset of variables related to pain severity were the best predictors of health care seeking after adjustment for age and gender. However, these accounted for only 22% of the log likelihood. In conclusion, more than one third of an unselected middle-aged population reported chronic abdominal pain or disturbed defecation, and more than one in six had symptoms compatible with the irritable bowel syndrome. Only a minority had presented for medical evaluation; moreover, the characteristics of the abdominal complaints did not explain the seeking of health care in most cases.

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BackgroundInfluential
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BackgroundMethodResultInfluential
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“These criteria have subsequently been modi ed by various investigators (4, 8, 9) and other new criteria (10, 11), including the consensus criteria of Rome I (12) and its recent revision, Rome II (13), have been produced.”
Background
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Result
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Identification of distinct upper and lower gastrointestinal symptom groupings in an urban population
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Evidence of a Genetic Contribution to Functional Bowel Disorder
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“In this sample, the prevalence of functional bowel disorder is lower than in community-based studies of IBS, in which the prevalence has been found to range between 9% and 22% (3, 4).”
BackgroundSelf-citation
British Society of Gastroenterology guidelines for the management of the irritable bowel syndrome
Jones, J. R. A., Boorman, J., Cann, P., Forbes, A., Gomborone, J., Heaton, K., Hungin, P., Kumar, D., Libby, G., Spiller, R. E., et al. (2000) · Gut · doi:10.1136/gut.47.suppl_2.ii1 · Cited by 226
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Treatment of irritable bowel syndrome with herbal preparations: results of a double‐blind, randomized, placebo‐controlled, multi‐centre trial
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Background
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Tegaserod
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Self-citation
Risk factors for irritable bowel syndrome: role of analgesics and food sensitivities
Locke, G. R., Zinsmeister, A. R., Talley, N. J., Fett, S. L., & Melton, L. J. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.01678.x · Cited by 185
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ResultSelf-citation
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“We present the results organized in four themes reflecting the goals of the study: (1) Current knowledge and misconceptions about IBS, (2) educational needs regarding IBS, (3) subgroup analysis of the educational needs based on subgroups by clinic/Web use status, (4) current knowledge and misconceptions about IBS, and…”
BackgroundMethod
Meta‐analysis: do irritable bowel syndrome symptoms vary between men and women?
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Background
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Self-citation
Asian consensus on irritable bowel syndrome
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Authors: Talley, N. J., Zinsmeister, A. R., van Dyke, C., & Melton, L. J.
Affiliations: Mayo Clinic (US)
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 1991-10
Volume: 101
Issue: 4
Pages: 927-934
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1016/0016-5085(91)90717-y
OpenAlex: W1606920119
Cited by: 648
References: 33
Citations by year: 2026: 2 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 10 · 2020: 7 · 2019: 4 · 2018: 9 · 2017: 10 · 2016: 8 · 2015: 19 · 2014: 26 · 2013: 16 · 2012: 25
FWCI: 17.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p30dk034988-05)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 34988)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR030582, AR30582)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: irritable bowel syndrome, functional gastrointestinal disorders, prevalence, abdominal pain, chronic constipation, chronic diarrhea, health-seeking behavior, middle-aged adults, sex differences, Olmsted County, Minnesota, community survey, unmet care needs
MeSH terms: Colonic Diseases, Functional, Constipation, Diarrhea, Female, Humans, Male, Middle Aged, Minnesota, Patient Acceptance of Health Care, Surveys and Questionnaires, Abdominal Pain, Prevalence

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Epidemiology of colonic symptoms and the irritable bowel syndrome

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