Cited by 362Clinical Nutrition and GastroenterologySepsis Diagnosis and TreatmentAbdominal vascular conditions and treatments

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The prevalence of gut translocation in humans

Sedman, Peter C, Macfle, John, Sagar, Peter, Mitchell, Charles J, May, John, Mancey-Jones, Ben, Johnstone, Derek·1994·Gastroenterology

DOI 10.1016/0016-5085(94)90110-4

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Abstract

Background/aims Gut translocation of enteric organisms across the intact intestinal mucosa has been postulated as a potential source of sepsis in susceptible patients. However, little is known of its occurrence or significance in humans. The aim of this study was to determine the prevalence of gut translocation of bacteria in humans and attempt to identify any predisposing factors to its occurrence.Methods A consecutive series of 267 general surgical patients were examined for evidence of bacterial translocation by bacterial analysis of intestinal serosa and mesenteric lymph nodes taken at the time of surgery.Results Translocation occurred in 10.3% of patients overall. Both aerobic and anaerobic bacteria translocated. Excluding patients with distal intestinal obstruction and those with inflammatory bowel disease in whom translocation was more common, the prevalence was 5%. Neither jaundice, nutritional status, nor total parenteral nutrition predisposed to translocation. Similarly, mucosal atrophy did not predispose to this phenomenon. The development of postoperative septic complications was twice as common in patients with translocation as in those without, but mortality was unaffected.Conclusions Translocation occurs as a spontaneous event in humans, but its clinical significance remains to be defined.

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Authors: Sedman, P. C., Macfle, J., Sagar, P., Mitchell, C. J., May, J., Mancey-Jones, B., & Johnstone, D.
Affiliations: Scarborough General Hospital (GB)
ORCID: Sagar, Peter
May, John
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 1994-09
Volume: 107
Issue: 3
Pages: 643-649
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1016/0016-5085(94)90110-4
OpenAlex: W2081580608
Cited by: 362
References: 54
Citations by year: 2026: 1 · 2025: 6 · 2024: 12 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 12 · 2019: 8 · 2018: 9 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 11 · 2012: 4
FWCI: 24.66
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
Keywords: bacterial translocation, gut translocation, prevalence, sepsis, mesenteric lymph nodes, general surgical patients, postoperative septic complications, anaerobic bacteria, aerobic bacteria, predisposing factors, inflammatory bowel disease, mucosal atrophy, total parenteral nutrition
MeSH terms: Bacterial Infections, Cell Movement, Humans, Intestines, Lymph Nodes, Mesentery, Postoperative Complications, Serous Membrane, Incidence, Bacterial Physiological Phenomena

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The prevalence of gut translocation in humans

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