The DOI matches its Crossref record; 53 of the 54 references it cites were found in a registry or an index.
The prevalence of gut translocation in humans
Abstract
Background/aims Gut translocation of enteric organisms across the intact intestinal mucosa has been postulated as a potential source of sepsis in susceptible patients. However, little is known of its occurrence or significance in humans. The aim of this study was to determine the prevalence of gut translocation of bacteria in humans and attempt to identify any predisposing factors to its occurrence.Methods A consecutive series of 267 general surgical patients were examined for evidence of bacterial translocation by bacterial analysis of intestinal serosa and mesenteric lymph nodes taken at the time of surgery.Results Translocation occurred in 10.3% of patients overall. Both aerobic and anaerobic bacteria translocated. Excluding patients with distal intestinal obstruction and those with inflammatory bowel disease in whom translocation was more common, the prevalence was 5%. Neither jaundice, nutritional status, nor total parenteral nutrition predisposed to translocation. Similarly, mucosal atrophy did not predispose to this phenomenon. The development of postoperative septic complications was twice as common in patients with translocation as in those without, but mortality was unaffected.Conclusions Translocation occurs as a spontaneous event in humans, but its clinical significance remains to be defined.
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“In animals (including humans), bacteria regularly cross barriers in the skin, mouth, gut, lungs, and other mucosal surfaces due to routine damage and intrinsic leakiness ( 13, 14 ); mirror bacteria would be expected to do the same.”
From Confronting risks of mirror life (2024) · cites this paper as [13]
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“Substantial clinical and experimental evidence supports the gut-lymph hypothesis.”
From The microbiome and critical illness (2016) · cites this paper as [103]
In the citing paper
“detection of bacteria in mesenteric lymph is predictive of subsequent sepsis and infectious complications.”
From The microbiome and critical illness (2016) · cites this paper as [103]
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Multimodal approach to control postoperative pathophysiology and rehabilitation
Kehlet, H. (1997) · British Journal of Anaesthesia · doi:10.1093/bja/78.5.606 · Cited by 2,830
Host–microbiota interactions in inflammatory bowel disease
Caruso, R., Lo, B. C., & Núñez, G. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-019-0268-7 · Cited by 808
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Metadata
- Authors
- Sedman, P. C., Macfle, J., Sagar, P., Mitchell, C. J., May, J., Mancey-Jones, B., & Johnstone, D.
- Affiliations
- Scarborough General Hospital (GB)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1994-09
- Volume
- 107
- Issue
- 3
- Pages
- 643-649
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2081580608
- Cited by
- 362
- References
- 54
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 12 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 12 · 2019: 8 · 2018: 9 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 11 · 2012: 4
- FWCI
- 24.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Keywords
- bacterial translocation, gut translocation, prevalence, sepsis, mesenteric lymph nodes, general surgical patients, postoperative septic complications, anaerobic bacteria, aerobic bacteria, predisposing factors, inflammatory bowel disease, mucosal atrophy, total parenteral nutrition
- MeSH terms
- Bacterial Infections, Cell Movement, Humans, Intestines, Lymph Nodes, Mesentery, Postoperative Complications, Serous Membrane, Incidence, Bacterial Physiological Phenomena
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