The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Controlled trial of metronidazole treatment for prevention of crohn's recurrence after ileal resection
Abstract
Background/aims New lesions recur within weeks to months after ileal resection and ileocolonic anastomosis for Crohn's ileitis. A double-blind controlled trial was performed using metronidazole to prevent recurrence after ileal resection.Methods Sixty patients who underwent curative ileal resection and primary anastomosis were included within 1 week after surgery. Thirty patients received metronidazole (20 mg/kg body wt) daily for 3 months, and 30 patients received placebo. Treatment was then discontinued. Nine patients dropped out during treatment, 7 in the metronidazole group and 2 in the placebo arm.Results At 12 weeks, 21 of 28 patients (75%) in the placebo group had recurrent lesions in the neoterminal ileum as compared with 12 of 23 patients (52%) in the metronidazole group (P = 0.09). The incidence of severe endoscopic recurrence was significantly reduced by metronidazole (3 of 23; 13%) as compared with placebo (12 of 28; 43%; P = 0.02). Patients in the metronidazole arm had more frequent side effects. Metronidazole therapy statistically reduced the clinical recurrence rates at 1 year (4% vs. 25%). Reductions at 2 years (26% vs. 43%) and 3 years (30% vs. 50%) were not significant.Conclusions Metronidazole therapy for 3 months decreases the severity of early recurrence of Crohn's disease in the neoterminal ileum after resection and seems to delay symptomatic recurrence.
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“Patients who have had a resection for CD have a decreased rate of endoscopic and clinical recurrence when metronidazole or ornidazole are used as prophylactic therapies.78”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [78]
In the citing paper
“Antibiotics demonstrate efficacy in particular groups of patients with CD”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [78]
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“Antibiotics have been proved to be efficacious in inducing and maintaining IBD remission [38-40] .”
BackgroundAzathioprine as a postoperative prophylaxis reduces symptoms in aggressive Crohn's disease
Myrelid, P., Svärm, S., Andersson, P., Almer, S. H., Bodemar, G., & Olaison, G. (2006) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520600587378 · Cited by 21
“Budesonide reduced endoscopic recurrence only in a subset of patients operated on for an inflammatory indication [6] and antibiotics such as metronidazole have been tried with some efficacy during the first postoperative year [7].”
BackgroundUstekinumab is a promising option for the treatment of postoperative recurrence of Crohn's disease
Macaluso, F. S., Grova, M., Mocciaro, F., Mitri, R. D., Privitera, A. C., Distefano, M. E., Vitello, A., Camilleri, S., Ferracane, C., Pluchino, D., et al. (2023) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16208 · Cited by 20
Adherence to an elemental diet for preventing postoperative recurrence of Crohn’s disease
Ohara, N., Mizushima, T., Iijima, H., Takahashi, H., Hiyama, S., Haraguchi, N., Inoue, T., Nishimura, J., Shinzaki, S., Hata, T., et al. (2017) · Surgery Today · doi:10.1007/s00595-017-1543-5 · Cited by 19
Conventional therapy for Crohn’s disease
Büning, C., & Lochs, H. H. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.12.4794 · Cited by 20
Treatment of Postoperative Crohn’s Disease
Froehlich, F., Juillerat, P., Felley, C. P., Mottet, C., Vader, J.-P., Burnand, B., Michetti, P., & Gonvers, J. (2005) · Digestion · doi:10.1159/000083873 · Cited by 20
Vasquez, N., Suau, A., Magne, F., Pochart, P., & Pélissier, M. A. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.01731-08 · Cited by 19
Medical Management of Crohn Disease
Scott, F. I., & Osterman, M. T. (2013) · Clinics in Colon and Rectal Surgery · doi:10.1055/s-0033-1348043 · Cited by 20
Fortinsky, K. J., Kevans, D., Qiang, J. K., Xu, W., Bellolio, F., Steinhart, H., Milgrom, R., Greenberg, G. R., Cohen, Z., MacRae, H., et al. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4351-7 · Cited by 19
Antioxidant Effects of Metronidazole in Colonic Tissue
Pélissier, M. A., Marteau, P. R., & Pochart, P. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9231-0 · Cited by 19
“Metronidazole (MTZ; 1-[2-hydroxyethyl]-2-methyl-5nitroimidazole), a narrow-spectrum antibiotic effective against anaerobic bacteria and various protozoans, decreases the risk of postoperative recurrence of CD [10] and is effective in pouchitis [11].”
BackgroundIleal Crohn's disease is best treated by surgery
Windsor, A. C. J. (2002) · Gut · doi:10.1136/gut.51.1.11 · Cited by 19
Poulsen, A., Rasmussen, J., Wewer, M. D., Hansen, E. H., Nordestgaard, R. L. M., Jespersen, H. S. R., Christiansen, D., Surnacheva, E., Lin, V. A., Aydemir, N., et al. (2024) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjae070 · Cited by 18
From Aphthous Ulcer to Full-Blown Crohn’s Disease
Rutgeerts, P. J. (2011) · Digestive Diseases · doi:10.1159/000323922 · Cited by 18
Self-citationLimitations in assessment of mucosal healing in inflammatory bowel disease.
Freeman, H. J. (2010) · PubMed Central · doi:10.3748/wjg.v16.i1.15 · Cited by 18
Management of post-operative Crohn’s disease in 2017: where do we go from here?
Nguyen, V. Q. C., Kanth, R., Gazo, J. G., & Sorrentino, D. R. (2016) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2016.1241708 · Cited by 18
Perioperative management of ileocecal Crohn’s disease in the current era
Yamamoto, T., Lightner, A. L., Spinelli, A., & Kotze, P. G. (2020) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2020.1802245 · Cited by 18
The Yin and Yang of host-commensal mutualism
Tchaptchet, S., & Hansen, J. J. (2011) · Gut Microbes · doi:10.4161/gmic.19089 · Cited by 22
“Antibiotics may effectively treat Crohn-related fistulae and decrease postoperative recurrence of Crohn ileitis.(24,25) Altered composition of commensal microbial communities is associated with IBD.”
BackgroundSurgical Considerations in the Treatment of Small Bowel Crohn’s Disease
Maguire, L. H., Alavi, K., Sudan, R., Wise, P. E., Kaiser, A. M., & Bordeianou, L. (2016) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-016-3330-9 · Cited by 18
PERSISTENCE OF HEMOSTATIC ALTERATIONS IN PATIENTS AFFECTED BY CROHN'S DISEASE AFTER BOWEL SURGERY
Chiarantini, E., Valanzano, R., Liotta, A. A., Cellai, A. P., Ilari, I., Prisco, D., Antonucci, E., Tonelli, F., & Abbate, R. (1997) · Thrombosis Research · doi:10.1016/s0049-3848(97)00183-7 · Cited by 18
Maintenance Therapy in Crohn's Disease
Steinhart, H. (2000) · Canadian Journal of Gastroenterology · doi:10.1155/2000/480782 · Cited by 18
Management of Inflammatory Bowel Disease: Does Rifaximin Offer Any Promise?
Gionchetti, P., Rizzello, F., Morselli, C., Romagnoli, R., & Campieri, M. (2005) · Chemotherapy · doi:10.1159/000081995 · Cited by 18
Kennedy, E. D., Urbach, D. R., Krahn, M. D., Steinhart, H., Cohen, Z., & McLeod, R. S. (2004) · Diseases of the Colon & Rectum · doi:10.1007/s10350-004-0725-6 · Cited by 18
Recent Advances in Inflammatory Bowel Disease
Farrell, R. J., Banerjee, S., & Peppercorn, M. A. (2001) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/20014091084173 · Cited by 18
Antibiotics in pediatric inflammatory bowel diseases: a systematic review
Verburgt, C. M., Heutink, W. P., Kuilboer, L. I. M., Dickmann, J. D., van Etten‐Jamaludin, F. S., Benninga, M. A., de Jonge, W. J., Limbergen, J. V., & Tabbers, M. M. (2021) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2021.1940956 · Cited by 17
Metadata
- Authors
- Rutgeerts, P., Hiele, M., Geboes, K., Peeters, M., Penninckx, F., Aerts, R., & Kerremans, R.
- Affiliations
- Universitair Ziekenhuis Leuven (BE)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1995-06
- Volume
- 108
- Issue
- 6
- Pages
- 1617-1621
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1980212383
- Cited by
- 743
- References
- 24
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 14 · 2023: 14 · 2022: 6 · 2021: 13 · 2020: 18 · 2019: 17 · 2018: 13 · 2017: 26 · 2016: 27 · 2015: 28 · 2014: 28 · 2013: 25 · 2012: 28
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Surgery › Diverticular Disease and Complications
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- metronidazole, Crohn's disease, ileal resection, ileocolic anastomosis, postoperative recurrence, recurrence prevention, endoscopic recurrence
- MeSH terms
- Adult, Crohn Disease, Double-Blind Method, Follow-Up Studies, Humans, Ileum, Metronidazole, Middle Aged, Recurrence
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