Controlled trial of bowel rest and nutritional support in the management of Crohn's disease
Open accessAbstract
To define the role of bowel rest as an independent variable from nutritional support a prospective, randomised controlled trial was undertaken in 51 patients with active Crohn's disease unresponsive to other medical management. Nutritional support for 21 days was randomised to total parenteral nutrition and nil by mouth (n = 17), defined formula diet administered through a nasogastric tube (n = 19), or partial parenteral nutrition and oral food (n = 15). Nutrient input in the first two groups provided 40 non-protein kcal/kg ideal body weight /d and 1g/ kg/d protein respectively, while the third group received 15 non-protein kcal/kg/d and 0.3 g/kg/d protein intravenously and ate unrestricted food. Clinical remissions occurred in 71% of patients on parenteral nutrition, in 58% on the defined formula diet and in 60% on partial parenteral nutrition; the probability for each group of being in remission at one year, after successful therapy was 42%, 55%, and 56% respectively. These differences were not significant. In patients with active Crohn's disease bowel rest was not a major factor in achieving a remission during nutritional support and did not influence outcome during one year's follow-up.
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A subsequent randomized controlled trial of nutritional interventions in CD found that bowel rest was not a major factor in achieving remission.
“A subsequent randomized controlled trial evaluating various nutritional interventions for patients with CD showed that bowel rest was not a major factor in achieving remission74.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [74]
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- Authors
- Greenberg, G. R., Fleming, C. R., Jeejeebhoy, K. N., Rosenberg, I. H., Sales, D., & Tremaine, W. J.
- Affiliations
- University of Toronto (CA)
- ORCID
- Rosenberg, I H
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1988-10
- Volume
- 29
- Issue
- 10
- Pages
- 1309-1315
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1434018
- OpenAlex
- W2101831405
- Cited by
- 296
- References
- 21
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 6 · 2021: 4 · 2020: 4 · 2019: 8 · 2018: 3 · 2017: 4 · 2016: 10 · 2015: 7 · 2014: 4 · 2013: 5 · 2012: 10
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Gastroenterological Association
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- Crohn's disease, bowel rest, nutritional support, total parenteral nutrition, partial parenteral nutrition, nasogastric tube feeding, clinical remission, protein intake, energy intake
- MeSH terms
- Adolescent, Adult, Clinical Trials as Topic, Crohn Disease, Eating, Enteral Nutrition, Female, Food, Formulated, Humans, Male, Middle Aged, Parenteral Nutrition, Parenteral Nutrition, Total, Prospective Studies, Random Allocation
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