CoChat
Sign Up
Cited by 743Inflammatory Bowel DiseaseDiverticular Disease and ComplicationsOcular Diseases and Behçet’s Syndrome

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Controlled trial of metronidazole treatment for prevention of crohn's recurrence after ileal resection

Rutgeerts, Paul, Hiele, Martin, Geboes, Karel, Peeters, Marc, Penninckx, Freddy, Aerts, Raymond, Kerremans, Raymond·1995·Gastroenterology
DOI 10.1016/0016-5085(95)90121-3
Open this paper in CoChat — free account

Abstract

Background/aims New lesions recur within weeks to months after ileal resection and ileocolonic anastomosis for Crohn's ileitis. A double-blind controlled trial was performed using metronidazole to prevent recurrence after ileal resection.Methods Sixty patients who underwent curative ileal resection and primary anastomosis were included within 1 week after surgery. Thirty patients received metronidazole (20 mg/kg body wt) daily for 3 months, and 30 patients received placebo. Treatment was then discontinued. Nine patients dropped out during treatment, 7 in the metronidazole group and 2 in the placebo arm.Results At 12 weeks, 21 of 28 patients (75%) in the placebo group had recurrent lesions in the neoterminal ileum as compared with 12 of 23 patients (52%) in the metronidazole group (P = 0.09). The incidence of severe endoscopic recurrence was significantly reduced by metronidazole (3 of 23; 13%) as compared with placebo (12 of 28; 43%; P = 0.02). Patients in the metronidazole arm had more frequent side effects. Metronidazole therapy statistically reduced the clinical recurrence rates at 1 year (4% vs. 25%). Reductions at 2 years (26% vs. 43%) and 3 years (30% vs. 50%) were not significant.Conclusions Metronidazole therapy for 3 months decreases the severity of early recurrence of Crohn's disease in the neoterminal ileum after resection and seems to delay symptomatic recurrence.

Overview

Integrity signals

Registry

Crossref · 10.1016/0016-5085(95)90121-3

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 1

  1. Malchow, 1987, The early signs of Crohn's disease after surgery: a prospective trial, Gastrointest Endosc, 33, 163

Cited by

Sorted by citations

See all 743

Related

See all

Metadata

Authors
Rutgeerts, P., Hiele, M., Geboes, K., Peeters, M., Penninckx, F., Aerts, R., & Kerremans, R.
Affiliations
Universitair Ziekenhuis Leuven (BE)
ORCID
Venue
Gastroenterology
Publisher
Elsevier BV
Published
1995-06
Volume
108
Issue
6
Pages
1617-1621
ISSN
0016-5085 (ISSN-L)
DOI
10.1016/0016-5085(95)90121-3
OpenAlex
W1980212383
Cited by
743
References
24
Citations by year
2026: 3 · 2025: 11 · 2024: 14 · 2023: 14 · 2022: 6 · 2021: 13 · 2020: 18 · 2019: 17 · 2018: 13 · 2017: 26 · 2016: 27 · 2015: 28 · 2014: 28 · 2013: 25 · 2012: 28
FWCI
10.61
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Surgery › Diverticular Disease and Complications
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords
metronidazole, Crohn's disease, ileal resection, ileocolic anastomosis, postoperative recurrence, recurrence prevention, endoscopic recurrence
MeSH terms
Adult, Crohn Disease, Double-Blind Method, Follow-Up Studies, Humans, Ileum, Metronidazole, Middle Aged, Recurrence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review