The effect of regular exercise on women receiving danazol for treatment of endometriosis
Abstract
OBJECTIVE: To determine the effects of regular exercise on women receiving danazol for the treatment of endometriosis. METHODS: Thirty-nine patients were randomized to a danazol-only or a danazol/exercise regimen in a prospective clinical trial carried out at tertiary care institutions. Patients in the danazol/exercise group were instructed to exercise four times per week, for 40 min per session, at an intensity of 20 metabolic units. Side effect profiles, pelvic symptoms, aerobic fitness, strength and hormone levels were compared for all subjects. The number of side effects of danazol was analyzed by the method of generalized estimating equations. RESULTS: The number of side effects reported during a 4-week period was 1.09-2.17 times greater for the danazol-only than for the danazol/exercise group. All patients had improvement of symptoms during treatment. The danazol/exercise group had significantly lower testosterone levels during treatment. The time to recurrence of endometriosis was not different between groups. CONCLUSIONS: Exercise during danazol therapy reduces the number of androgenic side effects. Relief of pain and time to recurrence are unaffected.
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Cardiovascular activity helps endometriosis patients maintain good energy levels, and exercise can increase serotonin levels.
“Cardiovascular activity helps endometriosis patients maintain good energy levels. Exercise is one of the most effective strategies for increasing serotonin levels; physical activity and deep breathing exercises can increase the rate of burning serotonin neurons in the brain, which can stimulate the production of mood-enhancing substances.”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [143]
Cites
Longitudinal Data Analysis for Discrete and Continuous Outcomes
Zeger, S. L., & Liang, K. (1986) · Biometrics · doi:10.2307/2531248 · Cited by 7,730 · see citing works
Danazol: Endocrine pharmacology and therapeutic applications
Barbieri, R. L., & Ryan, K. J. (1981) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(81)90611-6 · Cited by 208 · see citing works
Treatment of endometriosis with danazol: report of a 6-year prospective study
Buttram, V. C., Reiter, R. C., & Ward, S. (1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48431-1 · Cited by 131 · see citing works
Wheeler, G. D., SINGH, M., Pierce, W. D., Epling, W. F., & Cumming, D. C. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-2-422 · Cited by 120 · see citing works
Metabolic effects of anabolic steroid on skeletal muscle.
Rogozkin, V. A. (1979) · PubMed · Cited by 44 · see citing works
Free testosterone levels during danazol therapy
Nilsson, B., Södergård, R., Damber, M. ‐., et al. (1983) · Fertility and Sterility · doi:10.1016/s0015-0282(16)46941-4 · Cited by 42 · see citing works
Management of Pelvic Endometriosis with Low-Dose Danazol
Moore, E. E., Harger, J. H., Rock, J. A., et al. (1981) · Fertility and Sterility · doi:10.1016/s0015-0282(16)45611-6 · Cited by 38 · see citing works
Self-citationKoenig, H., Goldstone, A. D., & Lu, C. (1980) · Biochemical Journal · doi:10.1042/bj1920349 · Cited by 37 · see citing works
Management of pelvic endometriosis with low-dose danazol
Moore, E. E., Harger, J. H., Rock, J. A., & Archer, D. F. (1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48802-3 · Cited by 30 · see citing works
Self-citationInterference of Danazol with the radioimmunoassay of steroid hormones
Schwarz, S., & Boyd, J. (1982) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(82)90041-3 · Cited by 22 · see citing works
The effect of exercises on the content and reception of the steroid hormones in rat skeletal muscles
Tchaikovsky, V. S., Astratenkova, J. V., & Basharina, O. B. (1986) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(86)90059-2 · Cited by 21 · see citing works
Döberl, A., Bergqvist, A., Jeppsson, S., Koskimies, A. I., Rönnberg, L., Segerbrand, E., & Starup, J. (1984) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016348409156982 · Cited by 21 · see citing works
EFFECT OF CHRONIC EXERCISE ON THE PERSONALITY OF ADULTS
Ismail, A. H., & Young, R. J. (1977) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1977.tb38262.x · Cited by 17 · see citing works
Androgen cytosol binding during compensatory overload-induced skeletal muscle hypertrophy
Hickson, R. C., Kurowski, T. T., Galassi, T. M., Daniels, D. G., & Chatterton, R. J. (1985) · Canadian Journal of Biochemistry and Cell Biology · doi:10.1139/o85-051 · Cited by 16 · see citing works
The effect of swimming training on hormone levels in girls.
Carli, G., Martelli, G., Viti, A., et al. (1983) · PubMed · Cited by 16 · see citing works
Further studies on danazol interference in testosterone radioimmunoassays.
Sharp, A. M., Fraser, I. S., & Caterson, I. D. (1983) · Clinical Chemistry · doi:10.1093/clinchem/29.1.141 · Cited by 15 · see citing works
KEIZER, H. A., Beckers, E. J., de Haan, J., et al. (1987) · International Journal of Sports Medicine · doi:10.1055/s-2008-1025721 · Cited by 14 · see citing works
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Smolarz, B., Szyłło, K., & Romanowicz, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910554 · Cited by 560 · see citing works
Endometriosis and physical exercises: a systematic review
Bonocher, C. M., Montenegro, M. L., Rosa e Silva, J. C., Ferriani, R. A., & Meola, J. (2014) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-12-4 · Cited by 115 · see citing works
Brown, J., & Brown, S. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004142.pub2 · Cited by 82 · see citing works
RetractedEfficacy of exercise on pelvic pain and posture associated with endometriosis: within subject design
Awad, E., Ahmed, H. A. H., Yousef, A., & Abbas, R. (2017) · Journal of Physical Therapy Science · doi:10.1589/jpts.29.2112 · Cited by 61 · see citing works
- Authors
- Carpenter, S. E., Tjaden, B., Rock, J. A., & Kimball, A.
- Affiliations
- Emory University (US)
- Johns Hopkins University (US)
- ORCID
- Venue
- International Journal of Gynecology & Obstetrics
- Publisher
- Wiley
- Published
- 1995-06
- Volume
- 49
- Issue
- 3
- Pages
- 299-304
- ISSN
- 0020-6695 (ISSN-L)
- 0020-7292
- 1879-3479
- OpenAlex
- W2033344894
- Cited by
- 32
- References
- 17
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 3 · 2019: 1 · 2018: 2 · 2017: 2 · 2015: 3 · 2014: 2 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Gynecology & Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, danazol, physical activity, androgenic side effects, testosterone, cardiorespiratory fitness, strength, pelvic pain, recurrence, women
- MeSH terms
- Adult, Combined Modality Therapy, Danazol, Endometriosis, Estrogen Antagonists, Exercise Therapy, Female, Humans, Pain, Recurrence, Testosterone, Time Factors, Treatment Outcome
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