Depot leuprolide versus danazol in treatment of women with symptomatic endometriosis
Abstract
Objective We aimed to assess the efficacy of depot leuprolide versus danazol in the treatment of endometriosis. Study design A double-blind randomized trial of 270 patients from 22 centers compared the pretreatment and posttreatment laparoscopic extent of endometriosis. Pretreatment and posttreatment endometriosis symptoms and signs were assessed with standardized methods. Results When compared with danazol, leuprolide depot caused a more rapid and profound suppression of estradiol. Leuprolide depot and danazol were similarly efficacious in decreasing the extent of endometriosis, as well as the pain and tenderness associated with endometriosis. Conclusion Depot leuprolide is an effective alternative to danazol in decreasing the extent of endometriosis and endometriosis-related pain.
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Change in endometriosis score has been used to assess treatment effect under the assumption, unsupported by evidence, that lesion score correlates with pain score.
“Third, change in endometriosis score has been used to assess treatment effect with the assumption, but no evidence, that lesion score correlates with pain score”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Wheeler et al., 1992
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von Bruchhausen, F., Ebel, S., Hackenthal, E., Dannhardt, G., Frahm, A. W., Holzgrabe, U., Keller, K., Nürnberg, E., Rimpler, H., Schneider, G., et al. (1993) · Springer eBooks · doi:10.1007/978-3-642-57994-3_8
- Authors
- Wheeler, J. M., Knittle, J. D., & Miller, J. D.
- Affiliations
- Houston Methodist (US)
- Deerfield (United States) (US)
- Corresponding author
- Miller, James D.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1992-11
- Volume
- 167
- Issue
- 5
- Pages
- 1367-1371
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W16600810
- Cited by
- 106
- References
- 11
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 1
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, danazol, estradiol suppression, endometriosis-associated pain, GnRH agonist therapy, treatment efficacy comparison
- MeSH terms
- Adolescent, Adult, Danazol, Delayed-Action Preparations, Double-Blind Method, Endometriosis, Estradiol, Female, Genital Neoplasms, Female, Humans, Laparoscopy, Leuprolide
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