Biological and social predictors of health in an aging cohort
Abstract
A cohort of over 5000 men of Japanese ancestry, aged 46-69 and free of chronic disease at entry examination were studied for factors associated with remaining free of major chronic diseases during a 12 yr followup period. Over 1600 disease-free men were compared with 3400 individuals who developed coronary heart disease (CHD), stroke, cancer or a variety of other conditions. From more than 30 variables examined in multivariate analyses, blood pressure, obesity, cigarette smoking, alcohol consumption, serum glucose, uric acid and triglyceride, were inversely associated with staying healthy while forced vital capacity and years spent in Japan were directly associated with health. Of these nine variables, blood pressure was the strongest discriminator between healthy status and all categories of disease, while cigarette smoking and alcohol consumption were the next most important factors. This study suggests that the use of individuals who remain free of disease as a "standard" for health can facilitate the evaluation of risk factors for both total illness and a broad range of specific chronic diseases in a single population.
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Higher total serum and LDL cholesterol, lower HDL cholesterol, and higher relative weight are recognized risk factors for poor health outcomes including mortality, cardiovascular disease, and functioning loss.
“Metabolic parameters, including higher total serum and LDL cholesterol, lower HDL cholesterol, and higher relative weight, are also recognized risk factors for poor health outcomes including mortality, cardiovascular disease, and functioning loss.7,[11][12][13][14]”
From Socio‐economic differentials in peripheral biology: Cumulative allostatic load (2010) · cites this paper as [11]
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Socio‐economic differentials in peripheral biology: Cumulative allostatic load
Seeman, T., Epel, E., Gruenewald, T., Karlamangla, A., & McEwen, B. S. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05341.x · Cited by 579 · see citing works
- Authors
- Benfante, R., Reed, D., & Brody, J.
- Affiliations
- Kuakini Medical Center (US)
- National Institutes of Health (US)
- Venue
- Journal of Chronic Diseases
- Publisher
- Elsevier BV
- Published
- 1985-01
- Volume
- 38
- Issue
- 5
- Pages
- 385-395
- ISSN
- 0021-9681 (ISSN-L)
- OpenAlex
- W2027246399
- Cited by
- 55
- References
- 31
- Citations by year
- 2022: 1 · 2020: 1 · 2016: 2 · 2013: 1 · 2012: 3
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Chronic Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (N01 HV 02901)
- National Institute on Minority Health and Health Disparities (263-MD-319204)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
- Keywords
- chronic disease, coronary artery disease, stroke, cancer, risk factors, blood pressure, cigarette smoking, alcohol consumption, obesity, serum glucose, uric acid, triglycerides, forced vital capacity, Japanese ancestry, older men, predictors of health
- MeSH terms
- Aged, Aging, Alcohol Drinking, Anthropometry, Blood Glucose, Blood Pressure, Chronic Disease, Epidemiologic Methods, Follow-Up Studies, Hawaii, Health, Health Status, Hematocrit, Humans, Japan, Male, Middle Aged, Obesity, Risk, Smoking, Triglycerides, Uric Acid, Vital Capacity
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