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Control of the transport of reducing equivalents across the mitochondrial membrane in perfused rat heart
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“The glycerol 3-phosphate shuttle is not considered the major route of NADH shuttling in most mammalian cells but has been shown to be particularly active in brown adipose tissue and may be implicated in thermoregulation (105, 106, 107).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [107]
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“The components of the shuttle were verified in vitro, and the shuttle was quickly adopted as the predominant mechanism driving cytosolic NADH oxidation in heart and other mammalian tissues (107, 111).”
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Metadata
- Authors
- Safer, B.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Safer, B
- Venue
- Journal of Molecular and Cellular Cardiology
- Publisher
- Elsevier BV
- Published
- 1971-06
- Volume
- 2
- Issue
- 2
- Pages
- 111-124
- ISSN
- 0022-2828 (ISSN-L)
- OpenAlex
- W2024564250
- Cited by
- 118
- References
- 38
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 1 · 2012: 1
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular and Cellular Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- malate-aspartate shuttle, NADH reoxidation, aspartate aminotransferase, aminooxyacetic acid, triiodothyronine, citric acid cycle intermediates, alanine aminotransferase, lactate oxidation, glucose oxidation, rat heart
- MeSH terms
- Alanine Transaminase, Animals, Antimetabolites, Aspartate Aminotransferases, Biological Transport, Citric Acid Cycle, Glucose, Glycerophosphates, Glycolates, Heart, Homeostasis, Lactates, Malates, Male, Mitochondria, Muscle, Myocardium, NAD, Oxidation-Reduction, Perfusion, Triiodothyronine, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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