The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Sequence and spacing requirements of a retrovirus integration site
Open accessAbstract
Following infection, retroviruses insert a DNA copy of their RNA genome into the host cell genome. This integrative recombination reaction occurs at specific sites on the viral DNA: inverted repeat sequences near the termini of the linear DNA form of the viral genome. We have described elsewhere the generation and analysis of deletion mutations at one of the inverted repeat sequences in Moloney murine leukemia virus. We describe here the effects of insertion mutations made at this locus. Our results show that substantial sequence changes at the site of recombination can be tolerated, and that the spacing between the cleavage sites on the viral DNA can be expanded as well as contracted while still allowing efficient viral integration. After several rounds of virus replication, each of the insertion mutants gave rise to pseudorevertants with new alterations at the integration site.
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“Depending upon the retrovirus type, IN acts on ~16–20 terminal nucleotides of the LTR (Colicelli and Goff 1988, Withers-Ward et al. 1994, Masuda et al. 1998, Brown et al. 1999).”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Colicelli and Goff 1988
In the citing paper
“These cis-acting att sites are present in the form of imperfect inverted repeats and are both necessary and sufficient for integration both in vitro and in vivo (Fig. 7) (Colicelli and Goff 1988, Katzman et al. 1989, Bushman et al. 1990, Murphy et al. 1993, Brown et al. 1999).”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Colicelli and Goff 1988
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Metadata
- Authors
- Colicelli, J., & Goff, S. P.
- Affiliations
- Columbia University (US)
- ORCID
- Goff, Stephen P.
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1988-01
- Volume
- 199
- Issue
- 1
- Pages
- 47-59
- ISSN
- 0022-2836 (ISSN-L)
- OpenAlex
- W2041126567
- Cited by
- 198
- References
- 51
- Citations by year
- 2025: 2 · 2022: 2 · 2021: 1 · 2018: 3 · 2017: 2 · 2015: 2 · 2014: 8 · 2013: 2 · 2012: 7
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Molecular Biology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA 30488)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- retroviral integration, Moloney murine leukemia virus, inverted repeats, integration sites, insertion mutation, recombination, pseudorevertants, viral DNA
- MeSH terms
- Base Sequence, DNA, Circular, DNA, Viral, Genes, Viral, Molecular Sequence Data, Mutation, Phenotype, Recombination, Genetic, Retroviridae, Virus Replication
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