Metabolism of fetal and neonatal adrenal steroids
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During neonatal life, THA, 5α-THA and the polar metabolite 6α-hydroxy-THA are the more relevant corticosterone metabolites.
“during neonatal life, THA, 5α-THA and the polar metabolite 6α-hydroxy-THA are the more relevant corticosterone metabolites (Fig. 4(g)) [130].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [130]
Hydroxylation of the tetra- and hexahydro-metabolites of cortisol at the 1β- and 6α-carbon positions is quantitatively important in the neonatal period.
“Hydroxylation of the tetra- and hexahydro-metabolites of cortisol (e.g., THE and the cortolones) at 1β- and 6α-carbon position is quantitatively important in the neonatal period. [130].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [130]
Cites
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Self-citationThe Investigation of Steroid Metabolism in Early Infancy
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Self-citationALDOSTERONE AND SODIUM HOMEOSTASIS IN PRETERM INFANTS
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Self-citationCURRENT STATUS OF ESTROGEN ASSAYS IN OBSTETRICS AND GYNECOLOGY
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Urinary Steroid Levels in Newborn Infants with Intra-uterine Growth Retardation
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Identification of the androstenetriolones and androstenetetrols present in the urine of infants
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Self-citationUrinary Excretion of 17-Hydroxy- and 17-Deoxysteroids of the Pregn-4-ene Series by the Human Newborn
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Metabolism of Cortisol by the Human Newborn Infant1
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THE EFFECT OF EXOGENOUS HUMAN CHORIONIC GONADOTROPHIN ON STEROID EXCRETION IN THE NEWBORN
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Schiffer, L., Barnard, L., Baranowski, E. S., Gilligan, L. C., Taylor, A. E., Arlt, W., Shackleton, C. H. L., & Storbeck, K.-H. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105439 · Cited by 450 · see citing works
“are the more relevant corticosterone metabolites [130].”
Self-citationProfiling steroid hormones and urinary steroids
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Caulfield, M. P., Lynn, T., Gottschalk, M. E., Jones, K. L., Taylor, N. F., Malunowicz, E. M., Shackleton, C. H. L., Reitz, R. E., & Fisher, D. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.8.8712 · Cited by 120 · see citing works
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Self-citation
- Authors
- Shackleton, C. H. L., Honour, J. W., & Taylor, N. F.
- ORCID
- Honour, J.W.
- Venue
- Journal of Steroid Biochemistry
- Publisher
- Elsevier BV
- Published
- 1979-07
- Volume
- 11
- Issue
- 1
- Pages
- 523-529
- ISSN
- 0022-4731 (ISSN-L)
- OpenAlex
- W2021578672
- Cited by
- 49
- References
- 23
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2021: 1 · 2019: 1 · 2018: 2 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Steroid Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- corticosteroid metabolites, corticosterone, aldosterone, glucuronidation, sulfation, amniotic fluid, 21-hydroxylation, hydroxylase activity, pregnancy urine, infant urine
- MeSH terms
- Adrenal Cortex Hormones, Adrenal Glands, Adult, Androgens, Chromatography, Gas, Corticosterone, Female, Fetus, Glucuronates, Hormones, Humans, Hydrocortisone, Infant, Newborn, Placenta, Pregnancy, Pregnancy Trimester, Third, Steroids, Sulfatases
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