Reduction of aldosterone by anaerobic bacteria: origin of urinary 21-deoxy metabolites in man
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Reactions catalyzed by different strains of gut bacteria include A-ring reduction, reduction of the Δ5-double bond, reduction of 17-keto estrogens and 17-keto androstenes, 17,20-cleavage of 17α-hydroxysteroids, and 16α- and 21-dehydroxylation.
“Reactions catalyzed by different strains of gut bacteria include (1) A-ring reduction, (2) reduction of the Δ5-double bond, (3) reduction of 17-keto estrogens and 17-keto androstenes, (4) 17,20-cleavage of 17α-hydroxysteroids, and (5) 16α- and 21-dehydroxylation”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [149]
Cites
Shackleton, C. H. L., & Honour, J. W. (1976) · Clinica Chimica Acta · doi:10.1016/0009-8981(76)90505-2 · Cited by 163 · see citing works
Self-citationIsolation and characterization of human fecal bacteria capable of 21-dehydroxylating corticoids
Bokkenheuser, V. D., Winter, J., Dehazya, P., & Kelly, W. G. (1977) · Applied and Environmental Microbiology · doi:10.1128/aem.34.5.571-575.1977 · Cited by 78 · see citing works
Self-citationKelly, W. G., Bandi, L., Shoolery, J. Ν., & Lieberman, S. (1962) · Biochemistry · doi:10.1021/bi00907a026 · Cited by 61 · see citing works
Steroids in Germfree and Conventional Rats
Eriksson, H., Gustafsson, J.-Α., & Sjövall, J. (1969) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1969.tb00644.x · Cited by 53 · see citing works
21-dehydroxylation of corticoids by anaerobic bacteria isolated from human fecal flora
Winter, J., & Bokkenheuser, V. D. (1978) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(78)90604-0 · Cited by 51 · see citing works
Self-citationMetabolism of Deoxycorticosterone by Human Fecal Flora
Bokkenheuser, V. D., Suzuki, J. B., Polovsky, S. B., et al. (1975) · Applied Microbiology · doi:10.1128/am.30.1.82-90.1975 · Cited by 47 · see citing works
Self-citationFormation and metabolism of tetrahydrodeoxycorticosterone by human fecal flora
Bokkenheuser, V. D., Winter, J., Dehazyz, P., Leon, O. D., & Kelly, W. G. (1976) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(76)90187-4 · Cited by 45 · see citing works
Self-citation(1955) · JAMA · doi:10.1001/jama.1955.02960160038009 · Cited by 43 · see citing works
Feighner, S. D., Bokkenheuser, V. D., Winter, J., et al. (1979) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(79)90094-8 · Cited by 43 · see citing works
Self-citationKelly, W. G., Bandi, L., & Lieberman, S. (1962) · Biochemistry · doi:10.1021/bi00911a011 · Cited by 36 · see citing works
Mass spectrometric analysis for tetrahydroaldosterone
Honour, J. W., & Shackleton, C. H. L. (1977) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(77)90023-1 · Cited by 31 · see citing works
Self-citationABSENCE OF 21-DEHYDROXYLATION IN CONGENITAL ADRENAL HYPERPLASIA*
Fukushima, D. K., & Gallagher, T. F. (1958) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-18-7-694 · Cited by 27 · see citing works
Kelly, W. G., Bandi, L., & Lieberman, S. (1963) · Biochemistry · doi:10.1021/bi00906a013 · Cited by 22 · see citing works
Metabolism of Deoxycorticosterone by Human Fecal Flora
Bokkenheuser, V. D., Suzuki, J. B., Polovsky, S. B., et al. (1975) · Applied Microbiology · doi:10.1128/aem.30.1.82-90.1975 · Cited by 21 · see citing works
Self-citationEvered, D. C. (1975) · BMJ · doi:10.1136/bmj.3.5985.713 · Cited by 15 · see citing works
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Schiffer, L., Barnard, L., Baranowski, E. S., Gilligan, L. C., Taylor, A. E., Arlt, W., Shackleton, C. H. L., & Storbeck, K.-H. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105439 · Cited by 450 · see citing works
Self-citationBacterial formation of aldosterone metabolites
Winter, J., Shackleton, C. H. L., O'rourke, S., & Bokkenheuser, V. D. (1984) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(84)90332-7 · Cited by 16 · see citing works
- Authors
- Bokkenheuser, V. D., Winter, J., Honour, J. W., & Shackleton, C. H. L.
- Affiliations
- St. Luke's-Roosevelt Hospital Center (US)
- Space Sciences Laboratory (US)
- Corresponding author
- Shackleton, C.H.L.
- ORCID
- Honour, J.W.
- Venue
- Journal of Steroid Biochemistry
- Publisher
- Elsevier BV
- Published
- 1979-08
- Volume
- 11
- Issue
- 2
- Pages
- 1145-1149
- ISSN
- 0022-4731 (ISSN-L)
- OpenAlex
- W1998056202
- Cited by
- 30
- References
- 15
- Citations by year
- 2025: 2 · 2023: 3 · 2022: 1 · 2019: 2 · 2015: 1
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Steroid Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- aldosterone, Clostridium paraputrificum, Eubacterium lentum, tetrahydroaldosterone, urinary steroid metabolites, steroidogenesis
- MeSH terms
- Aldosterone, Clostridium, Eubacterium, Feces, Humans, Gas Chromatography-Mass Spectrometry
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