Possible role of regional superoxide dismutase activity and lipid peroxide levels in cadmium neurotoxicity: in vivo and in vitro studies in growing rats
Abstract
Cd2+ (0.4 mg/kg) administration to growing rats (45 +/- 5 g) intraperitoneally, daily for 30 days was found to decrease the activity of superoxide dismutase (SOD) in all the brain regions, except hippocampus. The concentrations of lipid peroxides were significantly elevated in the cerebellum, cerebral cortex, corpus striatum and midbrain. A 100% inhibition in SOD activity was observed by 14 microM and 50 microM of Cd2+ in bovine blood and rat brain preparations, respectively. Cadmium-induced strong inhibitory effect on brain and purified bovine blood SOD suggested a direct effect of the metal on enzyme molecule. Furthermore, in vitro addition of a wide range of Cd2+ (1-100 microM) increased the rate of lipid peroxidation (LPO) reaction in fresh brain homogenate, however, did not affect boiled homogenate. The studies on LPO in reconstituted homogenate resulting from mixing of fresh and/or heated different subcellular fractions indicated the presence of some heat-labile Cd2+ -sensitive factor in 15000 x g pellet fraction. It is suggested that Cd2+ directly and indirectly through inhibition of SOD, increases the LPO of cell membranes and thus produces damage to the associated physiological functions leading to central nervous dysfunctions.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Lithium helps antioxidant defense mechanisms through the management of GST.
“while also helping antioxidant defense mechanisms through the management of GST [260].”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [260]
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,460 · see citing works
Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels
Beauchamp, C., & Fridovich, I. (1971) · Analytical Biochemistry · doi:10.1016/0003-2697(71)90370-8 · Cited by 12,892 · see citing works
Marklund, S. L., & MARKLUND, G. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03714.x · Cited by 10,382 · see citing works
Misra, H. P., & Fridovich, I. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45228-9 · Cited by 9,097 · see citing works
REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I
Glowinski, J., & Iversen, L. L. (1966) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1966.tb09873.x · Cited by 5,436 · see citing works
Fridovich (1978) · doi:10.1126/science.210504 · Cited by 3,329 · see citing works
Superoxide Radical: An Endogenous Toxicant
Fridovich, I. (1983) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.23.040183.001323 · Cited by 1,168 · see citing works
A simplified assay method of superoxide dismutase activity for clinical use
Masayasu, M., & Hiroshi, Y. (1979) · Clinica Chimica Acta · doi:10.1016/0009-8981(79)90211-0 · Cited by 557 · see citing works
Wilbur, K. M., Bernheim, F., & Shapiro, O. W. (1949) · PubMed · Cited by 490 · see citing works
Effect of sulfhydryl reagents on peroxidation in microsomes
Utley, H. G., Bernheim, F., & Hochstein, P. E. (1967) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(67)90273-1 · Cited by 446 · see citing works
New aspects in the biological role of zinc: A stabilizer of macromolecules and biological membranes
Chvapil, M. S. (1973) · Life Sciences · doi:10.1016/0024-3205(73)90372-x · Cited by 385 · see citing works
Clinical Chemistry and Chemical Toxicology of Metals
Delves, H. T. (1978) · Biochemical Society Transactions · doi:10.1042/bst0060700a · Cited by 326 · see citing works
Hair Element Content in Learning Disabled Children
Pihl, R. O., & Parkes, M. (1977) · Science · doi:10.1126/science.905825 · Cited by 230 · see citing works
Cadmium toxicity and lipid peroxidation in isolated rat hepatocytes
Stacey, N. H., Cantilena, L. R., & Klaassen, C. D. (1980) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(80)90359-2 · Cited by 230 · see citing works
Protection by zinc against cadmium toxicity
Webb, M. H. (1972) · Biochemical Pharmacology · doi:10.1016/0006-2952(72)90024-x · Cited by 209 · see citing works
Hussain, T., Shukla, G. S., & Chandra, S. V. (1987) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1987.tb01526.x · Cited by 207 · see citing works
Self-citationShukla, G. S., & Singhal, R. L. (1984) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y84-171 · Cited by 163 · see citing works
Self-citationStacey, N. H., & Klaassen, C. D. (1981) · Journal of Toxicology and Environmental Health · doi:10.1080/15287398109529965 · Cited by 116 · see citing works
Developmental toxicology of energy-related pollutants
MAHLUM, D. D., Hackett, P., & Andrew, F. (1978) · University of North Texas Digital Library (University of North Texas) · Cited by 114 · see citing works
Lipid Peroxide Distribution in Brain and the Effect of Hyperbaric Oxygen
Noda, Y., McGeer, P. L., & McGeer, E. G. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb13574.x · Cited by 108 · see citing works
Bauer, R., Demeter, I., Hasemann, V., & Johansen, J. (1980) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(80)90560-4 · Cited by 100 · see citing works
Anosmia in Alkaline Battery Workers
Adams, R. G., & Crabtree, N. (1961) · Occupational and Environmental Medicine · doi:10.1136/oem.18.3.216 · Cited by 89 · see citing works
Rastogi, R. B., Merali, Z., & Singhal, R. L. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10629.x · Cited by 88 · see citing works
CADMIUM-INDUCED SELECTIVE LESIONS OF SENSORY GANGLIA
Gabbiani, G., Gregory, A., & Baić, D. (1967) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-196707000-00010 · Cited by 77 · see citing works
Enhancement of rat and human phagocyte superoxide anion radical production by cadmium in vitro
Amoruso, M. A., Witz, G., & Goldstein, B. D. (1982) · Toxicology Letters · doi:10.1016/0378-4274(82)90064-9 · Cited by 76 · see citing works
Hexum, T. D., & Fried, R. (1979) · Neurochemical Research · doi:10.1007/bf00963833 · Cited by 68 · see citing works
Shukla, G. S., & Chandra, S. (1987) · Archives of Environmental Contamination and Toxicology · doi:10.1007/bf01054947 · Cited by 64 · see citing works
Self-citationPrakash, N. J., Fontana, J., & Henkin, R. I. (1973) · Life Sciences · doi:10.1016/0024-3205(73)90106-9 · Cited by 54 · see citing works
Distribution of superoxide dismutase in rat brain
Thomas, T. N., Priest, D. G., & Zemp, J. W. (1976) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1976.tb01585.x · Cited by 45 · see citing works
Ascorbic acid—a naturally occurring mediator of lipid peroxide formation in rat brain1
Sharma, O. P., & Murti, C. R. K. (1976) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1976.tb01582.x · Cited by 43 · see citing works
Specificity of zinc pathway in the rabbit: zinc-cadmium exchange
Cotzias, G. C., Borg, D. C., & Selleck, B. (1961) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1961.201.1.63 · Cited by 39 · see citing works
Chandra, S. V., Murthy, R. C., Husain, T., & Bansal, S. K. (1984) · Acta Pharmacologica et Toxicologica · doi:10.1111/j.1600-0773.1984.tb01919.x · Cited by 34 · see citing works
Self-citationEarly Development of X-Cells in Kitten Lateral Geniculate Nucleus
Norman, J. L., Pettigrew, J. D., & Daniels, J. D. (1977) · Science · doi:10.1126/science.905824 · Cited by 34 · see citing works
Dopamine uptake in striatal synaptosomes exposed to peroxidation “in vitro”
Pastuszko, A., Gordon-Majszak, W., & Dąbrowiecki, Z. (1983) · Biochemical Pharmacology · doi:10.1016/0006-2952(83)90666-4 · Cited by 33 · see citing works
Species variation in manganese induced changes in brain biogenic amines
Shukla, G. S., & Chandra, S. V. (1979) · Toxicology Letters · doi:10.1016/0378-4274(79)90042-0 · Cited by 19 · see citing works
Self-citationCadmium-induced behavioral changes in growing rats.
Chandra, S. V., Murthy, R. C., & Ali, M. M. (1985) · Industrial Health · doi:10.2486/indhealth.23.159 · Cited by 16 · see citing works
Self-citationHussain, T., Ali, M. M., & Chandra, S. V. (1985) · Industrial Health · doi:10.2486/indhealth.23.199 · Cited by 14 · see citing works
Self-citationShank, K. E., & Vetter, R. J. (1974) · Environmental Letters · doi:10.1080/00139307409437340 · Cited by 10 · see citing works
Experimental Cadmium Poisoning III
Abe, T., & Itokawa, Y. (1973) · Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) · doi:10.1265/jjh.28.243 · Cited by 10 · see citing works
Op, S. (1977) · PubMed · Cited by 5 · see citing works
Oxygen Free Radicals and Tissue Damage: Ciba Foundation Symposium 65 (New Series)
Matteis, F. D. (1980) · Biochemical Society Transactions · doi:10.1042/bst0080775 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Lead neurotoxicity in children: basic mechanisms and clinical correlates
Lidsky, T. I., & Schneider, J. S. (2002) · Brain · doi:10.1093/brain/awg014 · Cited by 1,169 · see citing works
Heavy metals: Implications associated to fish consumption
Castro-González, M., & Armenta, M. M. (2008) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2008.06.001 · Cited by 709 · see citing works
Molecular inhibitory mechanisms of antioxidant enzymes in rat liver and kidney by cadmium
Casalino, E., Calzaretti, G., Sblano, C., & Landriscina, C. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00245-7 · Cited by 396 · see citing works
Manca, D., Ricard, A. C., Trottier, B. L., & Chevalier, G. (1991) · Toxicology · doi:10.1016/0300-483x(91)90030-5 · Cited by 320 · see citing works
Méndez‐Armenta, M., & Rı́os, C. (2006) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2006.11.009 · Cited by 313 · see citing works
Goering, P. L., Waalkes, M. P., & Klaassen, C. D. (1995) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-79162-8_9 · Cited by 307 · see citing works
Environmental occurrence, health effects and management of lead poisoning
Flora, S. J. S., Flora, G., & Saxena, G. (2006) · Elsevier eBooks · doi:10.1016/b978-044452945-9/50004-x · Cited by 282 · see citing works
Apoptosis and necrosis: two distinct events induced by cadmium in cortical neurons in culture
López, E., Figueroa, S., Oset‐Gasque, M. J., & González, M. P. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705111 · Cited by 270 · see citing works
Possible Role of Oxidative Damage in Metal-Induced Carcinogenesis
Kasprzak, K. S. (1995) · Cancer Investigation · doi:10.3109/07357909509031921 · Cited by 259 · see citing works
Cadmium-induced neurotoxicity: still much ado
Pacini, A., Branca, J. J. V., & Morucci, G. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.239434 · Cited by 249 · see citing works
Shukla, A., Shukla, G. S., & Srimal, R. (1996) · Human & Experimental Toxicology · doi:10.1177/096032719601500507 · Cited by 223 · see citing works
Self-citationCadmium-induced Lipid Peroxidation and the Status of the Antioxidant System in Rat Tissues
Sarkar, S., Yadav, P., Trivedi, R., Bansal, A. K., & Bhatnagar, D. (1995) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/s0946-672x(11)80038-6 · Cited by 213 · see citing works
Ognjanović, B. I., Marković, S., Djordjević, N. Z., Trbojević, I. S., Štajn, A. Š., & Saičić, Z. S. (2009) · Reproductive Toxicology · doi:10.1016/j.reprotox.2009.11.009 · Cited by 197 · see citing works
Candelario‐Jalil, E., Mhadu, N. H., Al-Dalain, S. M., Martı́nez, G., & León, O. S. (2001) · Neuroscience Research · doi:10.1016/s0168-0102(01)00282-6 · Cited by 193 · see citing works
Neurotoxicity of Metal Mixtures
Andrade, V. M., Aschner, M., & dos Santos, A. P. M. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-60189-2_12 · Cited by 180 · see citing works
Faverney, C. R.-D., Devaux, A., Lafaurie, M., Girard, J. P., Bailly‐Maitre, B., & Rahmani, R. (2001) · Aquatic Toxicology · doi:10.1016/s0166-445x(00)00154-5 · Cited by 169 · see citing works
An update on oxidative stress-mediated organ pathophysiology
Rashid, K., Sinha, K., & Sil, P. C. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.09.026 · Cited by 139 · see citing works
Hansen, B. H., Rømma, S., Søfteland, L., Olsvik, P. A., & Andersen, R. A. (2006) · Chemosphere · doi:10.1016/j.chemosphere.2006.04.088 · Cited by 134 · see citing works
Role of cellular antioxidants in metal-induced damage
Sugiyama, M. (1994) · Cell Biology and Toxicology · doi:10.1007/bf00757183 · Cited by 130 · see citing works
Prasanthi, R., Devi, C. B., Davuljigari, C. B., Reddy, N. S., & Reddy, G. R. (2009) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2009.12.002 · Cited by 130 · see citing works
Faverney, C. R.-D., Orsini, N., de Sousa, G., & Rahmani, R. (2004) · Aquatic Toxicology · doi:10.1016/j.aquatox.2004.05.011 · Cited by 116 · see citing works
Cadmium-induced testes oxidative damage in rats can be influenced by dietary zinc intake
Oteiza, P. I., Adonaylo, V. N., & Keen, C. L. (1999) · Toxicology · doi:10.1016/s0300-483x(99)00067-0 · Cited by 111 · see citing works
Enhanced brain regional lipid peroxidation in developing rats exposed to low level lead acetate
Villeda‐Hernández, J., Barroso-Moguel, R., Méndez‐Armenta, M., Nava-Ruíz, C., Huerta-Romero, R., & Rı́os, C. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00512-3 · Cited by 104 · see citing works
Balmus, I. M., Ciobica, A., Antioch, I., Dobrin, R., & Timofte, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3975101 · Cited by 103 · see citing works
“It also appears that lithium can boost GSH rates and also the expression of glutamatecysteine ligase [31], while also helping antioxidant defense mechanisms through the management of GST [260].”
BackgroundOxidative stress-mediated neurotoxicity of cadmium
Kumar, R., Agarwal, A. K., & Seth, P. K. (1996) · Toxicology Letters · doi:10.1016/s0378-4274(96)03780-0 · Cited by 101 · see citing works
Autophagy in Neurodegenerative Diseases and Metal Neurotoxicity
Zhang, Z., Miah, M. R., Culbreth, M. E., & Aschner, M. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1844-x · Cited by 101 · see citing works
Hansen, B. H., Rømma, S., Garmo, Ø. A., Pedersen, S. A., Olsvik, P. A., & Andersen, R. A. (2007) · Chemosphere · doi:10.1016/j.chemosphere.2006.12.048 · Cited by 98 · see citing works
İlhan, N., İlhan, N., & Simsek, M. (2002) · Clinical Biochemistry · doi:10.1016/s0009-9120(02)00336-3 · Cited by 94 · see citing works
O’Brien, P., & Salacinski, H. J. (1998) · Archives of Toxicology · doi:10.1007/s002040050562 · Cited by 94 · see citing works
Diving seals: are they a model for coping with oxidative stress?
Zenteno‐Savín, T., Clayton-Hernández, E., & Elsner, R. (2002) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/s1532-0456(02)00075-3 · Cited by 93 · see citing works
Das, J., Roy, A., & Sil, P. C. (2012) · Food & Function · doi:10.1039/c2fo30117b · Cited by 90 · see citing works
Neurochemical changes in newborn rat’s brain after gestational cadmium and lead exposure
Antonio, M. T., Corpas, I., & Leret, M. L. (1999) · Toxicology Letters · doi:10.1016/s0378-4274(98)00125-8 · Cited by 80 · see citing works
Milanés-Virelles, M. T., García‐García, I., Herrera, Y. S., Valdés-Quintana, M., Valenzuela‐Silva, C., Jiménez-Madrigal, G., Ramos, T. I., Rivero, I. B., Olivera, N. F., la Osa, R. B. S.-D., et al. (2008) · BMC Infectious Diseases · doi:10.1186/1471-2334-8-17 · Cited by 76 · see citing works
Cadmium induced testicular pathophysiology: Prophylactic role of taurine
Manna, P., Sinha, M., & Sil, P. C. (2008) · Reproductive Toxicology · doi:10.1016/j.reprotox.2008.09.009 · Cited by 76 · see citing works
Prabu, S. M., Muthumani, M., & Shagirtha, K. (2013) · PubMed · Cited by 76 · see citing works
Sinha, M., Manna, P., & Sil, P. C. (2009) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2009.03.010 · Cited by 75 · see citing works
Role of quercetin in cadmium-induced oxidative stress, neuronal damage, and apoptosis in rats
Ünsal, C., Kanter, M., Aktaş, C., & Erboğa, M. (2013) · Toxicology and Industrial Health · doi:10.1177/0748233713486960 · Cited by 75 · see citing works
CAO, D., Xu, J., Xue, R., ZHENG, W., & LIU, Z. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.09.016 · Cited by 73 · see citing works
Ajamieh, H., Berlanga, J., Merino, N., Martı́nez-Sánchez, G., Carmona, A. M., Cepero, S. A. M., Giuliani, A., Re, L., & León, O. S. (2005) · Transplant International · doi:10.1111/j.1432-2277.2005.00101.x · Cited by 72 · see citing works
Selective vulnerability to kainate‐induced oxidative damage in different rat brain regions
Candelario‐Jalil, E., Al‐Dalain, S. M., Castillo, R., Martı́nez, G., & Fernández, O. (2001) · Journal of Applied Toxicology · doi:10.1002/jat.768 · Cited by 72 · see citing works
Amelioration of cadmium-induced cardiac impairment by taurine
Manna, P., Sinha, M., & Sil, P. C. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.05.005 · Cited by 71 · see citing works
Heme oxygenase induction by cadmium chloride: evidence for oxidative stress involvement
Ossola, J. O. (1995) · Toxicology · doi:10.1016/0300-483x(95)03157-b · Cited by 69 · see citing works
Grosell, M. (2011) · Fish physiology · doi:10.1016/s1546-5098(11)31002-3 · Cited by 63 · see citing works
Shukla, G. S., Hussain, T., Srivastava, R. S., & Chandra, S. V. (1989) · Industrial Health · doi:10.2486/indhealth.27.59 · Cited by 63 · see citing works
Self-citationCadmium exposure induces mitochondria-dependent apoptosis in oligodendrocytes
Hossain, S., Liu, H., Nguyen, M., Shore, G. C., & Almazán, G. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2009.06.001 · Cited by 62 · see citing works
Shen, Y., & Sangiah, S. (1995) · Archives of Environmental Contamination and Toxicology · doi:10.1007/bf00212967 · Cited by 60 · see citing works
Sinha, C., Seth, K., Islam, F., Chaturvedi, R. K., Shukla, S., Mathur, N., Srivastava, N., & Agrawal, A. K. (2006) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2006.03.005 · Cited by 59 · see citing works
TNF-α and IL-10 downregulation and marked oxidative stress in Neuromyelitis Optica
Pentón‐Rol, G., Cervantes‐Llanos, M., Martı́nez-Sánchez, G., Cabrera-Gómez, J. A., Valenzuela‐Silva, C., Ramírez‐Núñez, O., Casanova-Orta, M., Robinson-Agramonte, M. A., Cabezas, I. L., & López-Saura, P. A. (2009) · Journal of Inflammation · doi:10.1186/1476-9255-6-18 · Cited by 55 · see citing works
Role of autophagy in environmental neurotoxicity
Pellacani, C., & Costa, L. G. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2017.12.102 · Cited by 53 · see citing works
Selective inhibition of the mouse brain Mn-SOD by methylmercury
Shinyashiki, M., Kumagai, Y., Homma‐Takeda, S., Nagafune, J., Takasawa, N., Suzuki, J. S., Matsuzaki, I., Satoh, S., Sagai, M., & Shimojo, N. (1996) · Environmental Toxicology and Pharmacology · doi:10.1016/s1382-6689(96)00070-1 · Cited by 53 · see citing works
del Pino, J., Zeballos, G., Anadón, M. J., Capo, M. A., Díaz, M. J. V., García, J., & Frejo, M. T. (2014) · Toxicology · doi:10.1016/j.tox.2014.09.004 · Cited by 50 · see citing works
Sumathi, T., Vedagiri, A., Somasundaram, S., Sakthimanogaran, R., & Murugesan, M. (2018) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2018.01.006 · Cited by 50 · see citing works
Nishimura, Y. H., Yamaguchi, J., Kanada, A., Horimoto, K., Kanemaru, K., Satoh, M., & Oyama, Y. (2005) · Toxicology in Vitro · doi:10.1016/j.tiv.2005.06.006 · Cited by 48 · see citing works
Time-varying associations between prenatal metal mixtures and rapid visual processing in children
Levin‐Schwartz, Y., Gennings, C., Schnaas, L., Chávez, M. D. C. H., Bellinger, D. C., Téllez‐Rojo, M. M., Baccarelli, A., & Wright, R. O. (2019) · Environmental Health · doi:10.1186/s12940-019-0526-y · Cited by 47 · see citing works
Glutathione status and cadmium neurotoxicity: Studies in discrete brain regions of growing rats
Shukla, G. S. (1988) · Fundamental and Applied Toxicology · doi:10.1016/0272-0590(88)90147-9 · Cited by 47 · see citing works
Self-citationHansen, B. H., Garmo, Ø. A., Olsvik, P. A., & Andersen, R. A. (2007) · Environmental Toxicology and Chemistry · doi:10.1897/06-380r.1 · Cited by 46 · see citing works
Shukla, G. S., & Chandra, S. (1989) · Journal of Applied Toxicology · doi:10.1002/jat.2550090209 · Cited by 42 · see citing works
Self-citationGupta, A., Gupta, A., & Shukla, G. S. (1995) · Human & Experimental Toxicology · doi:10.1177/096032719501400507 · Cited by 41 · see citing works
Self-citationWang, J., Ren, T., Wang, F., Han, Y., Liao, M., Jiang, Z., & Liu, H.-Y. (2016) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2016.01.029 · Cited by 41 · see citing works
Velázquez‐Pérez, L., Chanfrau, J. E. R., Rodríguez, J., Cruz, G. S., Aguilera‐Rodríguez, R., Rodríguez‐Labrada, R., Díaz, J. C. R., Canales‐Ochoa, N., Gotay, D. A., Mederos, L. E. A., et al. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0496-0 · Cited by 40 · see citing works
Serum vasoactive agents in rats poisoned with cadmium.
Martynowicz, H., Skoczyńska, A., Wojakowska, A., & Turczyn, B. (2004) · PubMed · Cited by 39 · see citing works
Saedi, S., Watson, S. E., Young, J. L., Tan, Y., Wintergerst, K. A., & Cai, L. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121385 · Cited by 38 · see citing works
Effects of dithiocarbamates on testicular toxicity in rats caused by acute exposure to cadmium
Kojima, S., Sugimura, Y., Hirukawa, H., KIYOZUMI, M., Shimada, H., & Funakoshi, T. (1992) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(92)90140-n · Cited by 37 · see citing works
Influence of antioxidants on cadmium toxicity of mouse preimplantation embryos in vitro
Peters, J. (1995) · Toxicology · doi:10.1016/0300-483x(94)02989-8 · Cited by 33 · see citing works
Effect of L-ascorbic acid tretreatment on cadmium toxicity in the male Fischer (F344/NCr) rat
Shiraishi, N., Uno, H., & Waalkes, M. P. (1993) · Toxicology · doi:10.1016/0300-483x(93)90034-p · Cited by 33 · see citing works
Gupta, A., Gupta, A., Nigam, D., Shukla, G. S., & Agarwal, A. K. (1999) · Journal of Applied Toxicology · doi:10.1002/(sici)1099-1263(199901/02)19:1 · Cited by 30 · see citing works
Self-citationCadmium-Induced Oxidative Stress in the Rat Testes: Protective Effects of Betaine
Kheradmand, A., Alirezaei, M., & Dezfoulian, O. (2013) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-013-9356-x · Cited by 29 · see citing works
Leão, L. K. R., Bittencourt, L. O., de Oliveira, A. C. A., Nascimento, P. C., Miranda, G. H. N., Ferreira, R. D. O., Nabiça, M. G., Dantas, K. D. G. F., Dionizio, A. S., Cartágenes, S. D. C., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103571 · Cited by 28 · see citing works
Faverney, C. R.-D., Lafaurie, M., Girard, J. P., & Rahmani, R. (2000) · Toxicology Letters · doi:10.1016/s0378-4274(99)00183-6 · Cited by 28 · see citing works
Acute exposure to cadmium causes time-dependent liver injury in rats
Theocharis, S. E., Margeli, A. P., Fasitsas, C. D., Loizidou, M., & Deliconstantinos, G. (1991) · Comparative Biochemistry and Physiology Part C Comparative Pharmacology · doi:10.1016/0742-8413(91)90087-a · Cited by 27 · see citing works
Upadhyay, T. K., Goel, H., Goyal, K., Pandey, A. K., Benjamin, M., Khan, F., Pandey, P., Mittan, S., Iqbal, D., Alsaweed, M., et al. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220329103610 · Cited by 25 · see citing works
The effect of combined administration of cadmium and furosemide on auditory function in the rat
Whitworth, C. A., Hudson, T. E., & Rybak, L. P. (1999) · Hearing Research · doi:10.1016/s0378-5955(98)00222-6 · Cited by 24 · see citing works
Gupta, A., Gupta, A., Datta, M., & Shukla, G. S. (2000) · Molecular and Cellular Biochemistry · doi:10.1023/a:1007000430394 · Cited by 23 · see citing works
Self-citationPrevention of cadmium‐induced effects on regional glutathione status of rat brain by vitamin E
Shukla, G. S., Srivastava, R. S., & Chandra, S. V. (1988) · Journal of Applied Toxicology · doi:10.1002/jat.2550080504 · Cited by 23 · see citing works
Self-citationSalovsky, P., Shopova, V., Dancheva, V., & Marev, R. (1992) · Human & Experimental Toxicology · doi:10.1177/096032719201100310 · Cited by 22 · see citing works
Time-dependent cadmium-neurotoxicity in rat brain synaptosomal plasma membranes
Fasitsas, C. D., Theocharis, S. E., Zoulas, D., Chrissimou, S., & Deliconstantinos, G. (1991) · Comparative Biochemistry and Physiology Part C Comparative Pharmacology · doi:10.1016/0742-8413(91)90167-r · Cited by 20 · see citing works
Villeda‐Hernández, J., Méndez‐Armenta, M., Barroso-Moguel, R., Trejo‐Solís, C., Guevara, J., & Rı́os, C. (2006) · PubMed · doi:10.14670/hh-21.609 · Cited by 20 · see citing works
Hispard, F., de Vaufleury, A., Martin, H., Devaux, S., Cosson, R. P., Scheifler, R., Richert, L., Berthelot, A., & Badot, P. (2007) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2007.04.005 · Cited by 20 · see citing works
Cell-based in vitro models in environmental toxicology: a review
Poteser, M. (2017) · Biomonitoring · doi:10.1515/bimo-2017-0002 · Cited by 19 · see citing works
Sujatha, R., Jayakumar, A. R., Krishnamoorthy, M. S., Paul, V., & Rajadas, J. (1999) · Environmental Toxicology and Pharmacology · doi:10.1016/s1382-6689(99)00013-7 · Cited by 18 · see citing works
Developmental neurotoxicity of cadmium on enzyme activities of crucial offspring rat brain regions
Stolakis, V., Tsakiris, S., Kalafatakis, K., Zarros, A. C., Skandali, N., Gkanti, V., Kyriakaki, A., & Liapi, C. A. (2013) · BioMetals · doi:10.1007/s10534-013-9678-3 · Cited by 17 · see citing works
Yargiçoğlu, P., Ağar, A., Oğuz, Y., i̇zgüt-Uysal, V. N., Şentürk, Ü. K., & Öneŕ, G. (1997) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(97)00016-0 · Cited by 17 · see citing works
Shukla, G. S., Hussain, T., & Chandra, S. V. (1988) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1988.tb00958.x · Cited by 15 · see citing works
Self-citationPrakash, P., Kumar, P. G., Laloraya, M., Javeri, T., & Parihar, M. S. (1997) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/s0742-8413(97)00082-0 · Cited by 13 · see citing works
Rana, S. V. S., & Singh, R. (1996) · Ichthyological Research · doi:10.1007/bf02347594 · Cited by 13 · see citing works
The Oxidative Damage Hypothesis of Metal-Induced Genotoxicity and Carcinogenesis
Kasprzak, K. S. (1997) · Springer eBooks · doi:10.1007/978-94-011-5780-3_5 · Cited by 13 · see citing works
Li, Y., Lan, W. A. N. G., Na, L. I. U., Qian, W. A. N. G., Yong-Ji, H. E., & Fan, M. E. N. G. (2008) · Acta Hydrobiologica Sinica · doi:10.3724/issn1000-3207-2008-3-373-j · Cited by 12 · see citing works
Aspects of Cadmium Neurotoxicity
Carageorgiou, H., & Katramadou, M. (2012) · Springer eBooks · doi:10.1007/978-1-4419-9663-3_33 · Cited by 10 · see citing works
Evaluation of Mesenchymal Stem Cells and Vitamin E in Treatment of Infertile Male Albino Rats
Hussein, Y. M., Rm, H., As, A. A. M., & Hs, H. (2015) · International Journal of Multidisciplinary and Current Research · Cited by 9 · see citing works
Agarwal, R., Gupta, A., & Shukla, G. S. (1999) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(99)00056-8 · Cited by 9 · see citing works
Self-citationCadmium and Fullerenes in Liver Diseases
Djurasevic, S. F., Todorović, Z., Pavlović, S. Z., & Pejić, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814466-4.00027-6 · Cited by 8 · see citing works
Iron ascorbate-stimulated lipid peroxidation in vitro. Why is the method controversial?
Łaszczyca, P., Kawka-Serwecińska, E., Witas, I., Doleżych, B., & Migula, P. (1995) · PubMed · Cited by 8 · see citing works
Iqbal, T., Jahan, S., Ain, Q. U., Ullah, H., Li, C., Chen, L., & Zhou, X. (2021) · Brazilian Journal of Biology · doi:10.1590/1519-6984.250865 · Cited by 7 · see citing works
Shen, Y., Sangiah, S., & Ye, M. Y. (1995) · Journal of Liquid Chromatography · doi:10.1080/10826079508010266 · Cited by 7 · see citing works
Developmental Neurotoxicity of Cadmium
Hastings, L., & Miller, M. M. (1998) · Elsevier eBooks · doi:10.1016/b978-012648860-9.50039-x · Cited by 6 · see citing works
Metals and Autophagy in Neurotoxicity
Su, P., Aschner, M., Chen, J., & Luo, W. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804562-6.00019-1 · Cited by 4 · see citing works
Cadmium-induced lipid peroxidation in rat liver slices: A possible involvement of hydroxyl radicals
Sarkar, S., Bhatnagar, D., & Yadav, P. (1994) · Toxicology in Vitro · doi:10.1016/0887-2333(94)90115-5 · Cited by 4 · see citing works
Lipid peroxidation induced by maternal cadmium exposure in mouse pups
Xu, B., Ya-pin, J., Feng, Z., Xu, Z., & Matsushita, T. (1993) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/bf00201657 · Cited by 4 · see citing works
On the Chemical Causation of Methyl Deficiency and its Attendant Pathologies
Poirier, L. A., Herrera, L. A., & Wise, C. (2003) · Cited by 4 · see citing works
Maternal cadmium intoxication: effects on fetal brain antioxidant defense parameters
Gupta, A., Gupta, A., & Shukla, G. S. (1996) · Redox Report · doi:10.1080/13510002.1996.11747049 · Cited by 3 · see citing works
Self-citation
- Authors
- Shukla, G. S., Hussain, T., & Chandra, S. V.
- Affiliations
- Indian Institute of Toxicology Research (IN)
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 1987-11
- Volume
- 41
- Issue
- 19
- Pages
- 2215-2221
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2017924999
- Cited by
- 113
- References
- 42
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 5 · 2012: 2
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- cadmium neurotoxicity, superoxide dismutase inhibition, lipid peroxidation, lipid hydroperoxides, brain, cadmium, oxidative stress, heat-labile factor, subcellular fractionation, growing rats
- MeSH terms
- Animals, Brain, Cadmium, Hot Temperature, Hippocampus, Lipid Peroxides, Male, Superoxide Dismutase, Rats, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review