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Cited by 113Heavy Metal Exposure and ToxicityTrace Elements in HealthAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Possible role of regional superoxide dismutase activity and lipid peroxide levels in cadmium neurotoxicity: in vivo and in vitro studies in growing rats

Shukla, Girja S., Hussain, T., Chandra, S.V.·1987·Life Sciences
DOI 10.1016/0024-3205(87)90518-2
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Abstract

Cd2+ (0.4 mg/kg) administration to growing rats (45 +/- 5 g) intraperitoneally, daily for 30 days was found to decrease the activity of superoxide dismutase (SOD) in all the brain regions, except hippocampus. The concentrations of lipid peroxides were significantly elevated in the cerebellum, cerebral cortex, corpus striatum and midbrain. A 100% inhibition in SOD activity was observed by 14 microM and 50 microM of Cd2+ in bovine blood and rat brain preparations, respectively. Cadmium-induced strong inhibitory effect on brain and purified bovine blood SOD suggested a direct effect of the metal on enzyme molecule. Furthermore, in vitro addition of a wide range of Cd2+ (1-100 microM) increased the rate of lipid peroxidation (LPO) reaction in fresh brain homogenate, however, did not affect boiled homogenate. The studies on LPO in reconstituted homogenate resulting from mixing of fresh and/or heated different subcellular fractions indicated the presence of some heat-labile Cd2+ -sensitive factor in 15000 x g pellet fraction. It is suggested that Cd2+ directly and indirectly through inhibition of SOD, increases the LPO of cell membranes and thus produces damage to the associated physiological functions leading to central nervous dysfunctions.

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Crossref · 10.1016/0024-3205(87)90518-2

Cites

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Citations

Cites

Show all 42 references

Research works printed but not linked: 12

  1. Vorobjeva, 1957, Zh. Nevropatol. Prikhiatr. im, S.S. Korsakova, 57, 385
  2. Adams, 1961, Br. J. Ind. Med., 18, 216
  3. Pihl, 1979, McGill J. Educ., 14, 353
  4. Wong, 1981, Toxicologists, 1, 225
  5. Smith, 1982, Neurobehav. Toxicol. Teratol., 4, 283
  6. Pfister, 1978, 37, 395
  7. Rozear, 1971, J. Pharmacol. Exp. Therp., 176, 109
  8. Wilber, 1949, Arch. Biochem. Biophys., 24, 305
  9. Banis, 1969, 130, 802
  10. Sharma, 1977, Indian J. Biochem. Biophys, 14, 264
  11. Early, 1978, Res. Commun. Chem. Pathol. Pharmacol., 19, 369
  12. Prasad, 1979, Ann. Rev. Pharmacol. Toxicol., 20, 293

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Related

Metadata

Authors
Shukla, G. S., Hussain, T., & Chandra, S. V.
Affiliations
Indian Institute of Toxicology Research (IN)
ORCID
Venue
Life Sciences
Publisher
Elsevier BV
Published
1987-11
Volume
41
Issue
19
Pages
2215-2221
ISSN
0024-3205 (ISSN-L)
DOI
10.1016/0024-3205(87)90518-2
OpenAlex
W2017924999
Cited by
113
References
42
Citations by year
2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 5 · 2012: 2
FWCI
2.38
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Life Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords
cadmium neurotoxicity, superoxide dismutase inhibition, lipid peroxidation, lipid hydroperoxides, brain, cadmium, oxidative stress, heat-labile factor, subcellular fractionation, growing rats
MeSH terms
Animals, Brain, Cadmium, Hot Temperature, Hippocampus, Lipid Peroxides, Male, Superoxide Dismutase, Rats, In Vitro Techniques

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