The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Prevention of exercise-induced muscle membrane damage by oestradiol
Abstract
Exercise can damage the muscle membrane, followed by leakage of certain muscle proteins into the bloodstream. This postexercise response differs for males and females; as an explanation for this difference it has been suggested that oestrogens have a protective effect on the female muscle membrane. We recently developed an animal exercise model in which postexercise damage can be studied in laboratory animals in vivo. A postexercise dimorphism, similar to that in humans, exists in rats and indirect evidence for the involvement of oestradiol (E2) was found. We report here 1) that ovariectomized females show postexercise damage like males, 2) that this response can be prevented by E2-replacement before exercise, and 3) that males, after E2-treatment, no longer show postexercise muscle damage. We therefore conclude that oestradiol indeed plays an important role in protecting skeletal muscle, both in females and in males.
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“Studies on muscle repair following exercise-induced injury highlight a sex-based difference in which higher levels of muscle creatine kinase (indicative of injury) are observed in male than in female rats following injury. Following OVX, levels of muscle creatine kinase in females are similar to levels in injured males (3, 4, 8).”
From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [8]
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Self-citation
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Metadata
- Authors
- Bär, P. R., Amelink, G. J., Oldenburg, B., & Blankenstein, M. A.
- Affiliations
- Utrecht University (NL)
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 1988-01
- Volume
- 42
- Issue
- 26
- Pages
- 2677-2681
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2029497561
- Cited by
- 133
- References
- 10
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 2 · 2019: 6 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 7 · 2014: 5 · 2013: 3 · 2012: 4
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Surgery › Muscle and Compartmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- exercise-induced muscle damage, estradiol, ovariectomy, sex differences, estrogen replacement therapy, rats
- MeSH terms
- Animals, Aspartate Aminotransferases, Cell Membrane Permeability, Creatine Kinase, Estradiol, Physical Exertion, Female, Male, Ovariectomy, Sarcolemma, Rats
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