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Cited by 534Stress Responses and CortisolCancer, Stress, Anesthesia, and Immune ResponseTryptophan and brain disorders

The DOI matches its Crossref record; 95 of the 97 references it cites were found in a registry or an index.

Stress and immunity: An integrated view of relationships between the brain and the immune system

Dantzer, Robert, Kelley, Keith W.·1989·Life Sciences
DOI 10.1016/0024-3205(89)90345-7
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Abstract

The old notion that stress exacerbates the progression of physical illness via its corticosteroid-mediated immunosuppressive effects must be revised. Experimental and clinical studies demonstrate that both laboratory and natural stressors alter the activities of lymphocytes and macrophages in a complex way that depends on the type of immune response, the physical and psychological characteristics of the stressor and the timing of stress relative to the induction and expression of the immune event. The influences of stress on immunity are mediated not only by glucocorticoids but also by catecholamines, endogenous opioids and pituitary hormones such as growth hormone. Sensitivity of the immune system to stress is not simply fortuitous but is an indirect consequence of the regulatory reciprocal influences that exist between the immune system and the central nervous system. The immune system receives signals from the brain and the neuroendocrine system via the autonomic nervous system and hormones and sends information to the brain via cytokines. These connections appear to be part of a long-loop regulatory feedback system that plays an important role in the coordination of behavioral and physiological responses to infection and inflammation.

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Crossref · 10.1016/0024-3205(89)90345-7

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Citations

Cites

Show all 97 references

Research works printed but not linked: 19

  1. Dorian, 1982, Clin. Exp. Immunol., 50, 132
  2. Glaser, 1986, Behav. Neurosci., 100, 675, 10.1037/0735-7044.100.5.675 · DOI
  3. Lancet, 1987, Editorial, 1, 1467
  4. Rasmussen, 1957, 96, 183
  5. Levine, 1962, 109, 294
  6. Kelley, 1980, Ann. Rech. Vet., 11, 445
  7. Sklar, 1981, Psychol. Med., 43, 331
  8. Blecha, 1982, 169, 239
  9. Vessey, 1964, 115, 252
  10. Coe, 1988, Immunological consequences of psychological disturbance and maternal loss in infancy, Vol. 5, 98
  11. Blecha, 1982, 169, 247
  12. Landmann, 1984, Clin. Exp. Immunol., 58, 127
  13. Yu, 1976, Clin. Exp. Immunol., 25, 472
  14. Shavit, 1986, 83, 7114
  15. Comsa, 1974, Immunol. Comm., 9, 11
  16. Melby, 1960, J. Lab. Clin. Med., 56, 50
  17. Besedovsky, 1975, 150, 466
  18. Sanders, 1985, Pharmacol. Rev., 37, 229
  19. Westly, 1987, 185, 211

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Metadata

Authors
Dantzer, R., & Kelley, K. W.
Affiliations
  • Inserm (FR)
  • University of Illinois Urbana-Champaign (US)
ORCID
Venue
Life Sciences
Publisher
Elsevier BV
Published
1989
Volume
44
Issue
26
Pages
1995-2008
ISSN
0024-3205 (ISSN-L)
DOI
10.1016/0024-3205(89)90345-7
OpenAlex
W2012740861
Cited by
534
References
97
Citations by year
2025: 2 · 2024: 8 · 2023: 10 · 2022: 7 · 2021: 16 · 2020: 9 · 2019: 11 · 2018: 9 · 2017: 7 · 2016: 8 · 2015: 18 · 2014: 9 · 2013: 15 · 2012: 16
FWCI
6.21
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Life Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • National Institutes of Health (AG 06246)
  • U.S. Department of Agriculture (86-CRCR-I-2003)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
stress, immunity, neuroimmune interactions, glucocorticoids, immunosuppression, catecholamines, endogenous opioids, growth hormone, cytokines, autonomic nervous system, neuroendocrine regulation, lymphocytes, macrophages, infection, inflammation
MeSH terms
Animals, Biological Factors, Brain, Hormones, Humans, Immune Tolerance, Stress, Physiological, Stress, Psychological, Cytokines, Neurotransmitter Agents

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