The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Adrenal glands of mouse and rat do not synthesize androgens
Abstract
Human adrenal glands produce considerable amounts of the C-19 steroids dehydroepiandrosterone (DHEA) and androstenedione. To investigate the capability of rodent adrenals to produce these steroids, cell suspensions of mouse and rat adrenal glands were incubated in the absence and presence of adrenocorticotropic hormone (ACTH). Corticosterone levels in the incubation medium increased dramatically in the presence of ACTH, but no significant amounts of 17-hydroxyprogesterone or androstenedione could be detected. This indicates that the adrenals of rat and mouse lack the enzyme 17 alpha-hydroxylase. Absence of plasma cortisol in the presence of high levels of corticosterone confirmed these data. Plasma levels of androstenedione were significantly decreased in castrated male rats as compared to levels observed in intact males, showing the contribution of the testes to the plasma content of androstenedione. Very low levels of androstenedione were observed in female, male and castrated male mice. Plasma concentrations of DHEA were not detectable in intact and castrated male mice and rats. It is concluded that rat and mouse lack the enzyme necessary to synthesize adrenal C-19 steroids and that the adrenals in these animals, therefore, do not contribute to plasma levels of androstenedione and DHEA.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Therefore, unlike humans, mouse and rat adrenals do not produce significant levels of androgen precursors (van Weerden et al., 1992) which can serve as substrates for intracrine action and are therefore not valid models for studies of human androgen intracrinology.”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as van Weerden et al., 1992
Citations
Cites
Bélanger, B., Bélanger, A., Labrie, F., Dupont, A., Cusan, L., & Monfette, G. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90514-1 · Cited by 212
STEROIDS OF ADRENAL ORIGIN METABOLIZED BY HUMAN PROSTATIC TISSUE BOTH IN VIVO AND IN VITRO
Harper, M. E., Pike, A. W., Peeling, W. B., & Griffiths, K. (1974) · Journal of Endocrinology · doi:10.1677/joe.0.0600117 · Cited by 190
Control of secretion and the function of C19-Δ5-steroids of the human adrenal gland
Adams, J. B. (1985) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(85)90138-8 · Cited by 161
Etomidate Suppresses Adrenocortical Function by Inhibition of 1 lβ-Hydroxylation
de Jong, F. H., Mallios, C., JANSEN, C., Scheck, P., & Lamberts, S. W. J. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-6-1143 · Cited by 159
Bruchovsky, N. (1971) · Endocrinology · doi:10.1210/endo-89-5-1212 · Cited by 151
Studies of Androgen Production by the Rat: Testosterone and Androstenedione Content of Blood1
Bardin, C. W., & Peterson, R. E. (1967) · Endocrinology · doi:10.1210/endo-80-1-38 · Cited by 129
de Jong, F. H., Baird, D. T., & van der Molen, H. J. (1974) · European Journal of Endocrinology · doi:10.1530/acta.0.0770575 · Cited by 100
Kyprianou, N., & Isaacs, J. T. (1987) · The Prostate · doi:10.1002/pros.2990110106 · Cited by 89
Kyprianou, N., & Isaacs, J. T. (1987) · The Prostate · doi:10.1002/pros.2990100405 · Cited by 63
Ellis, W. J., & Isaacs, J. T. (1985) · PubMed · Cited by 51
Research works printed but not linked: 3
- Ellis, 1985, Cancer Res., 45, 6041
- Labrie, 1988, Baillière's Clinical Oncology, 2, 597
- Arvola, 1961, Annls. Chir. Gynaec. Fenn., 50 suppl., 1
Cited by
Sorted by citations
Items 101–200 of 261
Dehydroepiandrosterone and Body Fat
Clore, J. N. (1995) · Obesity Research · doi:10.1002/j.1550-8528.1995.tb00234.x · Cited by 32
Williams, P., Jones, R., & Rademacher, T. W. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400519 · Cited by 32
Diethylstilboestrol for the treatment of prostate cancer: past, present and future
Turo, R., Smolski, M., Esler, R. C., Kujawa, M., Bromage, S. J., Oakley, N. E., Adeyoju, A., Brown, S. C., Brough, R., Sinclair, A. M., et al. (2013) · Scandinavian Journal of Urology · doi:10.3109/21681805.2013.861508 · Cited by 31
Grosser, G., Fietz, D., Günther, S., Bakhaus, K., Schweigmann, H., Ugele, B., Brehm, R., Petzinger, E., Bergmann, M., & Geyer, J. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.03.009 · Cited by 31
Effect of a novel 17,20-lyase inhibitor, orteronel (TAK-700), on androgen synthesis in male rats
Hara, T., Kouno, J., Kaku, T., Takeuchi, T., Kusaka, M., Tasaka, A., & Yamaoka, M. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.10.020 · Cited by 31
Shuid, A. N., El-arabi, E., Effendy, N. M., Razak, H. S. A., Muhammad, N., Mohamed, N., & Soelaiman, I. N. (2012) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-12-152 · Cited by 31
Sinha, P. S., Halasz, I., Choi, J. F., McGivern, R. F., & Redei, E. E. (1997) · Endocrinology · doi:10.1210/endo.138.11.5477 · Cited by 30
Ben-Yehuda, A., Danenberg, H. D., Zakay‐Rones, Z., Gross, D. J., & Friedman, G. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00017-7 · Cited by 30
Measurement of 11-dehydrocorticosterone in mice, rats and songbirds: Effects of age, sex and stress
Hamden, J. E., Salehzadeh, M., Jalabert, C., O’Leary, T. P., Snyder, J. S., Gómez-Sánchez, C. E., & Soma, K. K. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.05.018 · Cited by 31
Weldon, S. M., Cerny, M. A., Gueneva-Boucheva, K., Cogan, D. A., Guo, X., Moss, N., Parmentier, J. H., Richman, J. R., Reinhart, G. A., & Brown, N. F. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.236463 · Cited by 28
Will treating diabetes with 11β-HSD1 inhibitors affect the HPA axis?
Harno, E., & White, A. E. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.06.004 · Cited by 27
Kohut, M. L., Thompson, J. R., Campbell, J., Brown, G. A., Vukovich, M. D., Jackson, D. A., & King, D. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719319 · Cited by 27
Inhibitors of Aldosterone Synthase
Weldon, S. M., & Brown, N. F. (2018) · Vitamins and hormones · doi:10.1016/bs.vh.2018.10.002 · Cited by 26
Radojević, K., Arsenović-Ranin, N., Kosec, D. J., Pesic, V., Pilipović, I., Perišić, M., Plećaš‐Solarović, B., & Leposavić, G. (2007) · Journal of Endocrinology · doi:10.1677/joe.1.07019 · Cited by 26
Local glucocorticoid production in the thymus
Talabér, G., Jondal, M., & Okret, S. (2015) · Steroids · doi:10.1016/j.steroids.2015.06.010 · Cited by 26
Kalliokoski, O., Teilmann, A. C., Abelson, K., & Hau, J. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.12.008 · Cited by 25
Cumberland, A. L., Hirst, J. J., Badoer, E., Wudy, S. A., Greaves, R. F., Zacharin, M., & Walker, D. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094296 · Cited by 26
Gulfo, J., Castel, R., Ledda, A., Romero, M. D. M., Esteve, M., & Grasa, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-50355-1 · Cited by 23
HE3235 Inhibits Growth of Castration-Resistant Prostate Cancer
Koreckij, T. D., Trauger, R. J., Montgomery, B., Pitts, T. E. M., Coleman, I. M., Nguyen, H. M., Reading, C. L., Nelson, P. S., Vessella, R. L., & Corey, E. (2009) · Neoplasia · doi:10.1593/neo.09960 · Cited by 23
Dart, D. A., Brooke, G. N., Sita-Lumsden, A. R., Waxman, J., & Bevan, C. L. (2011) · Oncogene · doi:10.1038/onc.2011.591 · Cited by 23
Oksala, R., Moilanen, A., Riikonen, R., Rummakko, P., Karjalainen, A., Passiniemi, M., Wohlfahrt, G., Taavitsainen, P., Mälmström, C., Ramela, M., et al. (2018) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.02.004 · Cited by 23
Cloutier, M., Fleury, A., Courtemanche, J., Ducharme, L., Mason, J. I., & Lehoux, J. (1997) · DNA and Cell Biology · doi:10.1089/dna.1997.16.357 · Cited by 23
Bitter Taste Receptor Ligand Improves Metabolic and Reproductive Functions in a Murine Model of PCOS
Wu, S., Xue, P., Grayson, N., Bland, J. S., & Wolfe, A. (2018) · Endocrinology · doi:10.1210/en.2018-00711 · Cited by 22
Adrenals Contribute to Growth of Castration-Resistant VCaP Prostate Cancer Xenografts
Huhtaniemi, R., Oksala, R., Knuuttila, M., Mehmood, A., Aho, E., Laajala, T. D., Nicorici, D., Aittokallio, T. A., Laiho, A., Elo, L. L., et al. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.07.029 · Cited by 28
Lardy, H. A., Marwah, A. K., & Marwah, P. (2005) · Vitamins and hormones · doi:10.1016/s0083-6729(05)71009-8 · Cited by 22
Zhao, H., Thong, A. E. C., Nolley, R., Reese, S. W., Santos, J., Ingels, A., & Peehl, D. M. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-199 · Cited by 21
Vaňková, M., Hill, M., Velíková, M., Včelák, J., Vacínová, G., Dvořáková, K., Lukášová, P., Vejražková, D., Rusina, R., Holmerová, I., et al. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.12.011 · Cited by 21
Wright, S. K., & Fokidis, H. B. (2016) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2016.05.020 · Cited by 21
Analysis of Corticosterone and Testosterone Synthesis in Rat Salivary Gland Homogenates
Ieko, T., Sasaki, H., Maeda, N., Fujiki, J., Iwano, H., & Yokota, H. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00479 · Cited by 21
Effects of dietary equol administration on the mammary gland in ovariectomized Sprague-Dawley rats
Rachoń, D., Menche, A., Vortherms, T., Seidlová‐Wuttke, D., & Wuttke, W. (2008) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e318093df58 · Cited by 21
Mathieu, A. P., Auchus, R. J., & Lehoux, J. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(01)00172-8 · Cited by 21
A Novel Tissue-Specific Insight into Sex Steroid Fluctuations Throughout the Murine Estrous Cycle
Unger, C. A., Hope, M. C., Al-Adhami, A., Cotham, W. E., Socia, C. E., Rice, B. C., Clegg, D. J., Velázquez, K. T., LaVoie, H. A., Hollis, F., et al. (2023) · Endocrinology · doi:10.1210/endocr/bqad175 · Cited by 20
Testosterone and the heart: friend or foe?
Davis, S. R. (2023) · Climacteric · doi:10.1080/13697137.2023.2250252 · Cited by 20
Cell transplantation: A tool to study adrenocortical cell biology, physiology, and senescence
Hornsby, P. J., Thomas, M., Northrup, S. R., Popnikolov, N. K., Wang, X., Tunstead, J. R., & Zheng, J. Y. (1998) · Endocrine Research · doi:10.3109/07435809809032706 · Cited by 20
Testosterone deficiency reduces cardiac hypertrophy in a rat model of severe volume overload
Beaumont, C., Walsh‐Wilkinson, É., Drolet, M., Roussel, É., Melançon, N., Fortier, É., Harpin, G., Beaudoin, J., Arsenault, M., & Couët, J. (2019) · Physiological Reports · doi:10.14814/phy2.14088 · Cited by 19
González, F. B., Villar, S. R., Pacini, M. F., Bottasso, O. A., & Pérez, A. R. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165642 · Cited by 19
Gehrand, A. L., Phillips, J. M., Malott, K., & Raff, H. (2020) · Endocrinology · doi:10.1210/endocr/bqaa085 · Cited by 18
Barsky, S. T., & Monks, D. A. (2025) · Biology of Sex Differences · doi:10.1186/s13293-025-00707-6 · Cited by 20
Moll, J. M., Hofland, J., Teubel, W. J., Ridder, C. M. A. D., TAYLOR, A. E. R., Graeser, R., Arlt, W., Jenster, G. W., & van Weerden, W. M. (2022) · The Prostate · doi:10.1002/pros.24297 · Cited by 17
Diethylstilbestrol and docetaxel
Montgomery, B., Nelson, P. S., Lin, D. W., Ryan, C. W., Garzotto, M. G., & Beer, T. M. (2007) · Cancer · doi:10.1002/cncr.22917 · Cited by 18
Androgen receptor and 17β-HSD type 2 regulation in neonatal mouse lung development
Boucher, É. L., Provost, P. R., Plante, J., & Tremblay, Y. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.06.012 · Cited by 18
He, Y., Li, X., Li, Y., Kuai, D., Zhang, H., Wang, Y., & Tian, W. (2024) · Steroids · doi:10.1016/j.steroids.2024.109424 · Cited by 17
The role of androgens in experimental rodent mammary carcinogenesis
Choi, J. P., Psarommatis, B., Gao, Y., Zheng, Y., Handelsman, D. J., & Simanainen, U. (2014) · Breast Cancer Research · doi:10.1186/s13058-014-0483-x · Cited by 17
Reinwald, S., Mayer, L. P., Hoyer, P. B., Turner, C. H., Barnes, S., & Weaver, C. M. (2009) · Journal of Osteoporosis · doi:10.4061/2010/145170 · Cited by 17
Transplantation of Adrenocortical Cells
Hornsby, P. J. (2001) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/a:1011524701385 · Cited by 17
Current perspective on circadian function of the kidney
Benjamin, J. I., & Pollock, D. M. (2023) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00247.2023 · Cited by 18
Sexual dimorphism during integrative endocrine and immune responses to ionizing radiation in mice
Burke, M., Wong, K., Talyansky, Y., Mhatre, S. D., Mitchell, C., Juran, C. M., Olson, M., Iyer, J. S., Puukila, S., Tahimic, C. G. T., et al. (2024) · Scientific Reports · doi:10.1038/s41598-023-33629-7 · Cited by 16
Effects of separated pair housing of female C57BL/6JRj mice on well-being
Hohlbaum, K., Merle, R., Frahm, S., Rex, A., Palme, R., Thöne‐Reineke, C., & Ullmann, K. (2022) · Scientific Reports · doi:10.1038/s41598-022-12846-6 · Cited by 16
Challa, S. R., Fornal, C. A., Wang, B. C., Boyineni, J., DeVera, R. E., Unnam, P., Song, Y., Soares, M. B., Malchenko, S., Gyarmati, P., et al. (2023) · Chronic Stress · doi:10.1177/24705470231207010 · Cited by 16
Astrocyte Neuroprotection and Dehydroepiandrosterone
Arbo, B. D., Ribeiro, F. S., & Ribeiro, M. F. M. (2018) · Vitamins and hormones · doi:10.1016/bs.vh.2018.01.004 · Cited by 15
Dreyer, A., Jensen, R., Glintborg, D., Schmedes, A., Brandslund, I., Nielsen, F., Kyhl, H., Jensen, T., & Andersen, M. (2020) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/clinem/dgaa292 · Cited by 8
Lam, H., Nguyen, H. M., & Corey, E. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7845-8_1 · Cited by 14
Spörndly‐Nees, E., Boberg, J., Ekstedt, E., Holm, L., Fakhrzadeh, A., Dunder, L., Kushnir, M. M., Lejonklou, M. H., & Lind, P. (2018) · Reproductive Toxicology · doi:10.1016/j.reprotox.2018.08.007 · Cited by 16
Poulsen, C. B., Mortensen, M. B., Koechling, W., Sørensen, C. B., & Bentzon, J. F. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002800 · Cited by 14
Mathieu, A. P., Lehoux, J., & Auchus, R. J. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00488-9 · Cited by 14
Quinn, T., Ratnayake, U., Dickinson, H., Castillo-Meléndez, M., & Walker, D. W. (2015) · Developmental Neuroscience · doi:10.1159/000438986 · Cited by 13
Munley, K. M., Trinidad, J. C., Deyoe, J. E., Adaniya, C. H., Nowakowski, A. M., Ren, C. C., Murphy, G. V., Reinhart, J. M., & Demas, G. E. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12940 · Cited by 15
The genetic basis of adrenal gland weight and structure in BXD recombinant inbred mice
Curzio, D. L. D., & Goldowitz, D. (2011) · Mammalian Genome · doi:10.1007/s00335-011-9315-9 · Cited by 13
Steroid sulfates in domestic mammals and laboratory rodents
Schuler, G. C. (2021) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2021.106622 · Cited by 15
Kobayashi, Y., Tagawa, N., Muraoka, K., Okamoto, Y., & Nishida, M. (2003) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.26.1596 · Cited by 13
McGivern, R. F., & Handa, R. J. (1996) · PsycEXTRA Dataset · doi:10.1037/e495662006-005 · Cited by 13
Neuroendocrine contribution to sex-related variations in adverse air pollution health effects
Alewel, D. I., & Kodavanti, U. P. (2024) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937404.2024.2383637 · Cited by 12
Aoki, K., Tajima, K., Taguri, M., & Terauchi, Y. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.03.011 · Cited by 12
Female Reproductive Systems: Hormone Dependence and Receptor Expression
Kuan, K., & Saunders, P. T. K. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-11836-4_2 · Cited by 12
New insights into the protective effects of DHEA 1)
Niro, S., Hennebert, O., & Morfin, R. F. (2010) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2010.050 · Cited by 11
A seasonal switch hypothesis for the neuroendocrine control of aggression
Demas, G. E., Munley, K. M., & Jasnow, A. M. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.08.015 · Cited by 11
Cai, T., Stribling, S., Tong, X., Xu, L., Wısnıewskı, T., Fontenot, J. A., Struthers, M. D., & Akinsanya, K. (2014) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2014.09.011 · Cited by 11
Yao, Y., & Silver, R. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.877256 · Cited by 11
Peripubertal orchidectomy transitorily affects age-associated thymic involution in rats
Pesic, V., Radojević, K., Kosec, D. J., Plecas-Solarovic, B., Perisic, M., Pilipović, I., & Leposavić, G. (2007) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2007001100009 · Cited by 11
dos Santos, A. C., Viana, D. C., Bertassoli, B. M., Vasconcelos, B. G., de Oliveira, D. M., Rici, R. E. G., de Oliveira, M. F., Miglino, M. A., & Neto, A. C. D. A. (2016) · Brazilian Journal of Biology · doi:10.1590/1519-6984.23514 · Cited by 11
Does taste aversion play a role in the effect of dehydroepiandrosterone in zucker rats?
Wright, B. E., Abadie, J. M., Svec, F., & Porter, J. R. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90127-9 · Cited by 11
Mayer, D. (1998) · The Aging Male · doi:10.3109/13685539809148603 · Cited by 11
Comparative review of the brain development in Acomys cahirinus
Merkulyeva, N. S. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105939 · Cited by 10
Haider, A., Bengs, S., Portmann, A., Fröhlich, S., Etter, D., Marędziak, M., Warnock, G., Akhmedov, A. T., Kozerke, S., Keller, C., et al. (2025) · Biology of Sex Differences · doi:10.1186/s13293-024-00673-5 · Cited by 10
Mimicking women’s endocrine milieu in mice for women’s health-related studies
Constantin, C., Matvienko, D., László, C., Scabia, V., Battista, L., Binz, P., Bruce, S. J., & Brisken, C. (2025) · npj Women s Health · doi:10.1038/s44294-025-00060-4 · Cited by 9
Fokidis, H. B. (2016) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2016.05.024 · Cited by 10
Nyce, J. W. (2018) · Endocrine Related Cancer · doi:10.1530/erc-18-0241 · Cited by 10
Corticosterone biosynthesis in mouse clonal myoblastic C2C12 cells
Fujiki, J., Maeda, N., Sato, M., Ieko, T., Inoue, H., Iwasaki, T., Iwano, H., & Yokota, H. (2018) · Steroids · doi:10.1016/j.steroids.2018.07.001 · Cited by 9
Isenbrandt, A., Coulombe, K., Morissette, M., Bourque, M., Lamontagne‐Proulx, J., Paolo, T. D., & Soulet, D. (2023) · Pharmaceuticals · doi:10.3390/ph16020152 · Cited by 12
Consecutive Low Doses of Streptozotocin Induce Polycystic Ovary Syndrome Features in Mice
Ryu, Y., Kim, Y. J., Kim, Y. Y., Kim, J.-W., Kim, S. W., Kim, H., & Ku, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031299 · Cited by 9
Sex-Specific Impacts of Prenatal Stress
Barrett, E. S., & Lessing, J. (2021) · Springer eBooks · doi:10.1007/978-3-030-60159-1_10 · Cited by 8
The novel use of urinary androgens to optimise detection of the fertile window in giant pandas
Wilson, K. S., Li, D., Valentine, I., McNeilly, A. S., Girling, S. J., Li, R., Zhou, Y., Vanhaecke, L., Duncan, W. C., & Wauters, J. (2022) · Reproduction and Fertility · doi:10.1530/raf-22-0031 · Cited by 8
Rougée, L. R. A., Collier, A. C., & Richmond, R. H. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.608056 · Cited by 8
Goto, H., Yamashita, S., & Makita, T. (1998) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.47.257 · Cited by 8
Zatra, Y., Aknoun-Sail, N., Kheddache, A., Benmouloud, A., Charallah, S., Moudilou, E., Exbrayat, J., Khammar, F., & Amirat, Z. (2017) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.08.012 · Cited by 8
Catalina, F., Milewich, L., Kumar, V., & Bennett, M. (2003) · Experimental Biology and Medicine · doi:10.1177/153537020322801109 · Cited by 8
Human adrenocortical organoids for tissue regeneration and disease modeling
Li, Q., Li, X., Zhang, Y., Shen, Y., Lu, Z., Chen, W., Liu, Y., Wu, S., Gong, X., Li, X., et al. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102679 · Cited by 7
Moon, H. H., Clines, K. L., Cooks, M. A., Cialek, C. A., Esvelt, M. A., & Clines, G. A. (2019) · Endocrinology · doi:10.1210/en.2019-00261 · Cited by 7
Konishi, K., Cherkerzian, S., Jacobs, E. G., Richards, C. E., Remington, A., Aizley, H. G., Misra, M., Lasley, B. L., & Goldstein, J. M. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146303 · Cited by 7
Goto, H., Yamashita, S., & Makita, T. (1998) · Journal of Veterinary Medical Science · doi:10.1292/jvms.60.513 · Cited by 7
Schubert, C., Nishino, Y., & Michna, H. (1995) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/s0940-9602(11)80061-0 · Cited by 7
Joseph, S., Ubba, V., Wang, Z., Feng, M., Dsilva, M. K., Suero, S., Waheed, D., Snyder, N. W., Yang, X., Wang, H., et al. (2025) · Endocrinology · doi:10.1210/endocr/bqaf071 · Cited by 6
What does the research say about androgen use and cerebrovascular events?
Sadaie, M. R., Farhoudi, M., Zamanlu, M., Aghamohammadzadeh, N., Amouzegar, A., Rosenbaum, R. E., & Thomas, G. A. (2018) · Therapeutic Advances in Drug Safety · doi:10.1177/2042098618773318 · Cited by 7
Fernandez, N., Petit, A., Pianos, A., Haddad, L., Schumacher, M., Lière, P., & Guennoun, R. (2022) · Endocrinology · doi:10.1210/endocr/bqac183 · Cited by 6
Lehoux, J., Cloutier, M., Brière, N., & Martel, D. (1997) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549704501009 · Cited by 6
Role of Dehydroepiandrosterone in Experimental and Human Carcinogenesis
Feo, F., Pascale, R. M., Simile, M. M., & Miglio, M. R. D. (2011) · De Gruyter eBooks · doi:10.1515/9783110811162.215 · Cited by 6
Li, Z., Hales, B. F., & Robaire, B. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae154 · Cited by 5
Chen, K. L., Kenney, H. M., Schwarz, E. M., & Rahimi, H. (2024) · Journal of the Endocrine Society · doi:10.1210/jendso/bvae169 · Cited by 5
Venkatesh, V. S., Nie, T., Zajac, J. D., Grossmann, M., & Davey, R. A. (2023) · Current Osteoporosis Reports · doi:10.1007/s11914-023-00818-2 · Cited by 6
Endocrine control of sexual behavior
Ågmo, A. (2007) · Elsevier eBooks · doi:10.1016/b978-012370590-7/50006-2 · Cited by 5
Metadata
- Authors
- van Weerden, W. M., Bierings, H. G., Van Steenbrugge, G. J., De Jong, F. H., & Schröder, F. H.
- Affiliations
- Erasmus MC (NL)
- Erasmus University Rotterdam (NL)
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 1992-01
- Volume
- 50
- Issue
- 12
- Pages
- 857-861
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2041880296
- Cited by
- 260
- References
- 23
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 12 · 2023: 13 · 2022: 8 · 2021: 10 · 2020: 9 · 2019: 13 · 2018: 18 · 2017: 9 · 2016: 15 · 2015: 8 · 2014: 12 · 2013: 8 · 2012: 5
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- adrenal gland, androgen production, C19 steroids, dehydroepiandrosterone, androstenedione, 17α-hydroxylase, ACTH, corticosterone, 17-hydroxyprogesterone, testicular androgen production, castration
- MeSH terms
- Adrenal Cortex Hormones, Adrenal Glands, Adrenal Hyperplasia, Congenital, Adrenocorticotropic Hormone, Androgens, Animals, Castration, Female, Hydroxyprogesterones, Male, Mice, Inbred BALB C, Progesterone, Rats, Inbred Strains, Testis, 17-alpha-Hydroxyprogesterone, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review