Anabolic effect of dihydrotestosterone in testicular feminization syndrome
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Athletes with CAIS can compete fairly as females because the circulating testosterone, although at adult male levels, has no physiological effect, so that affected individuals are indistinguishable from females and gain no benefits of the sex difference arising from unimpeded testosterone action.
“Athletes with CAIS can compete fairly as females because the circulating testosterone, although at adult male levels, has no physiological effect so that, in terms of androgen action and the ensuing physical somatic advantages of male sex, affected individuals are indistinguishable from females and gain no benefits of the sex difference arising from unimpeded testosterone action.”
From Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance (2018) · cites this paper as [85]
Cites
The Conversion of Testosterone to 5α-Androstan-17β-ol-3-one by Rat Prostate in Vivo and in Vitro
Bruchovsky, N., & Wilson, J. D. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93542-8 · Cited by 1,027 · see citing works
Selective Retention of Dihydrotestosterone by Prostatic Nuclei
Anderson, K. M., & Liao, S. (1968) · Nature · doi:10.1038/219277a0 · Cited by 529 · see citing works
Wilson, J. D., & Walker, J. D. (1969) · Journal of Clinical Investigation · doi:10.1172/jci105994 · Cited by 275 · see citing works
Studies on testosterone metabolism in subjects with testicular feminization syndrome
MAUVAIS-JARVIS, P., Bercovici, J. P., Crépy, O., & Gauthier, F. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106219 · Cited by 111 · see citing works
Northcutt, R. C., Island, D. P., & Liddle, G. W. (1969) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-29-3-422 · Cited by 96 · see citing works
Testicular Feminization: Clinical, Morphological and Biochemical Studies
French, F. S., Baggett, B., Wyk, J. J. V., Talbert, L. M., Hubbard, W. R., JOHNSTON, F. R., WEAVER, R. P., Forchielli, E., Rao, G. S., & Sarda, I. R. (1965) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-25-5-661 · Cited by 82 · see citing works
Further Evidence of a Target Organ Defect in the Syndrome of Testicular Feminization1
French, F. S., Wyk, J. J. V., Baggett, B., EASTERLING, W. E., Talbert, L. M., JOHNSTON, R. F., Forchielli, E., & Dey, A. C. (1966) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-26-5-493 · Cited by 77 · see citing works
PRELIMINARY CHARACTERIZATION OF AN ANDROGEN-MACROMOLECULAR COMPLEX FROM THE RAT VENTRAL PROSTATE
Unhjem, O., Tveter, K. J., & Aakvaag, A. (1969) · European Journal of Endocrinology · doi:10.1530/acta.0.0620153 · Cited by 67 · see citing works
Plasma Concentration and Biosynthesis of Testosterone in the Syndrome of Feminizing Testes1
Southren, A. L., Ross, H., Sharma, D. C., Gordon, G. G., Weingold, A. B., & Dorfman, R. I. (1965) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-25-4-518 · Cited by 57 · see citing works
MAUVAIS-JARVIS, P., Bercovici, J. P., & Gauthier, F. (1969) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-29-3-417 · Cited by 56 · see citing works
Absence of response to dihydrotestosterone in the syndrome of testicular feminization
STRICKLAND, A. L., & FRENCH, F. S. (1969) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-29-9-1284 · Cited by 50 · see citing works
Studies of Androgens in the Syndrome of Male Pseudohermaphroditism with Testicular Feminization
Rivarola, M. A., Saez, J. M., Meyer, W. J., Kenny, F. M., & Migeon, C. J. (1967) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-27-3-371 · Cited by 50 · see citing works
Reduction of 5α-Position of Testosterone in the Rat Ventral Prostate
SHIMAZAKI, J., Matsushita, I., Furuya, N., Yamanaka, H., & Shida, K. (1969) · Endocrinologia Japonica · doi:10.1507/endocrj1954.16.453 · Cited by 42 · see citing works
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Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance
Handelsman, D. J., Hirschberg, A. L., & Bermon, S. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00020 · Cited by 594 · see citing works
Human male sexual maldevelopment: Teratogenetic classification of monogenic forms
Pinsky, L. (1974) · Teratology · doi:10.1002/tera.1420100216 · Cited by 3 · see citing works
- Authors
- Hamilton, C. R., & Kliman, B.
- Affiliations
- Massachusetts General Hospital (US)
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 1971-09
- Volume
- 20
- Issue
- 9
- Pages
- 870-877
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W1975428935
- Cited by
- 2
- References
- 13
- Citations by year
- 2018: 1
- FWCI
- 0.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- androgen insensitivity syndrome, dihydrotestosterone, anabolic response, gonadectomy, nitrogen balance, nuclear androgen receptor, hypogonadism, androgen resistance
- MeSH terms
- Adult, Olfaction Disorders, Body Weight, Castration, Cell Nucleus, Color Vision Defects, Creatinine, Estrogens, Eunuchism, Humans, Hypogonadism, Male, Intellectual Disability, Nitrogen, Phosphates, Receptors, Drug, Sex Chromosome Aberrations, Dihydrotestosterone, Stimulation, Chemical, Androgen-Insensitivity Syndrome, Testosterone, 17-Ketosteroids
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