Blunted norepinephrine responsiveness to changing energy states in obese subjects
Abstract
We have previously reported in lean subjects a significant relationship between plasma norepinephrine metabolism and energy state. The present study has examined in six obese men the response in plasma norepinephrine flux to ten day periods of overeating (+ 1000 kcal/m2 above isocaloric requirements) or undereating (400 kcal/d). Despite significant gains or losses in body weight, norepinephrine flux, measured during constant infusions of 3H-l-norepinephrine, failed to change significantly. Measurements of glucose utilization during constant infusions of insulin, showed significant changes with changing energy state, falling with overeating and rising with undereating. Insulin sensitivity was not correlated with plasma norepinephrine metabolism.
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A diet producing negative energy balance, with accompanying weight loss, reduces sympathetic activity and lowers blood pressure.
“A diet producing negative energy balance, with accompanying weight loss, reduces sympathetic activity and lowers blood pressure.111,112”
From Obesity Paradox in Hypertension: Is This Because Sympathetic Activation in Obesity-Hypertension Takes a Benign Form? (2018) · cites this paper as [111]
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Self-citation
- Authors
- Bazelmans, J., Nestel, P. J., O'Dea, K., & Esler, M. D.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- Corresponding author
- Nestel, P.J.
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 1985-02
- Volume
- 34
- Issue
- 2
- Pages
- 154-160
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2038193112
- Cited by
- 52
- References
- 32
- Citations by year
- 2023: 1 · 2017: 1
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- norepinephrine, obesity, energy state, overeating, undereating, glucose utilization, insulin sensitivity, weight change, sympathetic nervous system
- MeSH terms
- Adolescent, Adult, Blood Glucose, Body Surface Area, Body Weight, Energy Intake, Cholesterol, Energy Metabolism, Humans, Insulin, Kinetics, Male, Norepinephrine, Obesity, Random Allocation, Triglycerides
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