CoChat
Sign Up
Cited by 63Eating Disorders and BehaviorsNeuroendocrine regulation and behaviorRegulation of Appetite and Obesity

Effect of estrogen or insulin-induced hypoglycemia on plasma oxytocin levels in bulimia and anorexia nervosa

Chiodera, P., Volpi, R., Capretti, L., Marchesi, C., d'Amato, L., De Ferri, A., Bianconi, L., Coiro, V.·1991·Metabolism
DOI 10.1016/0026-0495(91)90220-q
Open this paper in CoChat — free account

Abstract

Plasma oxytocin (OT) levels were measured before and after stimulation with estrogens (1 mg ethynylestradiol orally) or with insulin (0.15 IU/kg)-induced hypoglycemia in seven underweight women with anorexia nervosa, eight normal weight bulimic women, and nine normal controls. Anorectic patients were amenorrhoic; they were tested at their first hospitalization (first tests) and again 8 to 9 weeks later (second tests) when they were eating normally, but were still at a low weight. In addition, anorectic women were tested 16 to 17 weeks after the first test (third tests), when their weight was restored to normal. Normal and bulimic women were tested on the fourth days of normal menstrual cycles. Insulin induced similar hypoglycemic responses in all groups. At each time point of the estrogen tests, plasma estrogen levels were similar in bulimic and normal women, whereas they were significantly lower in anorectic subjects. There were no differences in the basal levels of OT among groups. Both insulin-induced hypoglycemia and estrogen treatment produced striking OT increments in bulimic and control women, without significant differences between groups. During the first tests, no significant increase in plasma OT levels was observed in underweight anorectic women in response to both releasing stimuli. After partial weight recovery, the anorectic women showed a slight, but significant, increase in the OT responses to both insulin-induced hypoglycemia and estrogen administration. Both hypoglycemia- and estrogen-induced OT increases observed during the second tests were significantly lower in underweight anorectic patients than in normal controls. Anorectic subjects regained normal OT responsiveness to both stimuli after complete weight recovery.(ABSTRACT TRUNCATED AT 250 WORDS)

Integrity signals

Registry

Crossref · 10.1016/0026-0495(91)90220-q

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • OXT effects in women may vary as a function of steroid hormones.

    “Clearly, OXT effects in women may vary as a function of steroid hormones, which influence plasma levels of the peptide (Chiodera et al., 1991), regulate the expression of the OXTR gene (Quinones-Jenab et al., 1997) and affect OXTR function through a non-genomic mechanism (Grazzini et al., 1998).”

    From Hormonal contraceptives suppress oxytocin-induced brain reward responses to the partner’s face (2016) · cites this paper as Chiodera et al., 1991

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Chiodera, P., Volpi, R., Capretti, L., Marchesi, C., d'Amato, L., De Ferri, A., Bianconi, L., & Coiro, V.
Affiliations
University of Parma (IT)
Corresponding author
Chiodera, P.
ORCID
Volpi, R.
Venue
Metabolism
Publisher
Elsevier BV
Published
1991-11
Volume
40
Issue
11
Pages
1226-1230
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/0026-0495(91)90220-q
OpenAlex
W2147166849
Cited by
63
References
23
Citations by year
2026: 3 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 8 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 3
FWCI
1.08
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
oxytocin, anorexia nervosa, bulimia nervosa, insulin-induced hypoglycemia, estrogen, ethinyl estradiol, hypothalamic-pituitary-ovarian axis, neuroendocrine dysfunction, weight recovery, starvation, amenorrhea, eating disorders
MeSH terms
Anorexia Nervosa, Bulimia, Estrogens, Female, Humans, Hypoglycemia, Insulin, Oxytocin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review