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Cited by 67Diet and metabolism studiesMuscle metabolism and nutritionDietary Effects on Health

Protein sparing during treatment of obesity: ketogenic versus nonketogenic very low calorie diet

Vazquez, Jorge A., Adibi, Siamak A.·1992·Metabolism
DOI 10.1016/0026-0495(92)90076-m
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Abstract

Although it is generally agreed that both ketogenic and nonketogenic very low calorie diets promote weight reduction, there is no consensus on a preference of one diet over the other in regard to protein sparing. In the present study, we compared the effects of isocaloric (600 kcal/d) and isonitrogenous (8 g nitrogen/d) ketogenic (low carbohydrate) and nonketogenic diets on parameters of protein and amino acid metabolism, in 16 morbidly obese women maintained on these diets for 4 weeks while confined to a metabolic ward. Cumulative urinary nitrogen excretion (g/4 wk) was significantly (P less than .01) greater (248 +/- 6 v 207 +/- 12, mean +/- SEM, n = 8), and cumulative nitrogen balance significantly (P less than .02) more negative (-50.4 +/- 4.4 v -18.8 +/- 5.7), during treatment with the ketogenic than with the nonketogenic diet. Plasma leucine concentration (mumol/L) was significantly higher (P less than .05) during treatment with the ketogenic than with the nonketogenic diet at day 14 (210 +/- 17 v 150 +/- 8), but not at day 28 (174 +/- 9 v 148 +/- 8). Whole-body rates of leucine oxidation (mmol/h) were significantly higher (P less than .05) during treatment with the ketogenic than with the nonketogenic diet at day 14 (1.29 +/- 0.20 v 0.92 +/- 0.10) and at day 28 (1.00 +/- 0.16 v 0.75 +/- 0.10). Conversely, proteolysis, as measured by leucine turnover rate and urinary excretion of 3-methylhistidine, was not significantly different between the diets.(ABSTRACT TRUNCATED AT 250 WORDS)

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Authors
Vazquez, J. A., & Adibi, S. A.
Affiliations
University of Pittsburgh (US)
Venue
Metabolism
Publisher
Elsevier BV
Published
1992-04
Volume
41
Issue
4
Pages
406-414
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/0026-0495(92)90076-m
OpenAlex
W1980209192
Cited by
67
References
56
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 5 · 2014: 1 · 2013: 1 · 2012: 2
FWCI
1.08
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01dk015855-22, 7r29dk039157-04)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK15855, DK-39157)
  • National Center for Research Resources (M01RR000056, 5 M01 RR00056)
Topics
  • Health Sciences › Medicine › Physiology › Diet and metabolism studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords
protein sparing, ketogenic diet, very low calorie diet, morbid obesity, nitrogen balance, urinary nitrogen excretion, leucine oxidation, leucine turnover, proteolysis, 3-methylhistidine, amino acid metabolism, weight loss
MeSH terms
Amino Acids, Blood Proteins, Energy Intake, Creatinine, Diet, Reducing, Dietary Proteins, Energy Metabolism, Female, Hormones, Humans, Ketone Bodies, Methylhistidines, Middle Aged, Nitrogen, Obesity, Morbid, Time Factors, Weight Loss, Body Mass Index

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