Carbohydrate metabolism in primary growth hormone resistance (Laron syndrome) before and during insulin-like growth factor-I treatment
Abstract
Among 43 patients with Laron syndrome followed in our clinic, we were able to study the carbohydrate metabolism from infancy into adult age in 30 patients. During infancy, fasting blood glucose levels were in the hypoglycemic range (mean +/- SD, 3.5 +/- 1.2 mmol/L) and increased at the end of a delayed puberty to 4.6 +/- 0.6 mmol/L. Fasting plasma insulin was higher than expected for concomitant glucose levels, and several of the 20 patients who underwent an oral glucose tolerance test (OGTT) had glucose intolerance and relatively high insulin levels. In adult patients, insulinopenia developed and one 38-year-old patient developed non-insulin-dependent diabetes mellitus (NIDDM) with subsequent need for insulin therapy. Continuous insulin-like growth factor-I (IGF-I) treatment of a pubertal patient with glucose intolerance and hyperinsulinemia normalized both responses. In conclusion, long-term IGF-I deficiency leads to insulin resistance, which is reversed by exogenous IGF-I administration.
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Administration of IGF1 in humans results in decreased blood glucose levels and improved insulin sensitivity in those with and without type 2 diabetes.
“Administration of IGF1 in humans results in decreased blood glucose levels and improved insulin sensitivity in those with and without type 2 diabetes [[234], [235], [236]].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [234]
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Ekström, K. (2013) · Figshare
Generation and characterization of a pig model for Laron syndrome
Hinrichs, A. (2018) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.22856
Influence of Male Hyperinsulinemia on IVF Outcome
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Cali, G. M. L., Ruiz, L. F. N., & Reyes-Pérez, M. A. (2022) · Dilemas contemporáneos Educación Política y Valores · doi:10.46377/dilemas.v10i18.3430
Metabolism and Metabolic Regulation
Sackmann‐Sala, L., Miles, D. R. B., & Kopchick, J. J. (2010) · Springer eBooks · doi:10.1007/978-3-642-11183-9_52
Hinrichs, A., Pafili, K., Sancar, G., Laane, L., Zettler, S., Torgeman, M., Kessler, B., Nono, J. L., Kunz, S. L., Rathkolb, B., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102273
- Authors
- Laron, Z., Avitzur, Y., & Klinger, B.
- Affiliations
- Tel Aviv University (IL)
- Corresponding author
- Laron, Z.
- ORCID
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 1995-10
- Volume
- 44
- Issue
- 10 Suppl 4
- Pages
- 113-118
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2077327282
- Cited by
- 76
- References
- 30
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 2 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 2 · 2015: 4 · 2014: 5 · 2013: 4 · 2012: 3
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Keywords
- Laron syndrome, growth hormone resistance, carbohydrate metabolism, insulin-like growth factor I, insulin resistance, insulin deficiency, impaired glucose tolerance, hypoglycemia, fasting blood glucose, fasting insulin, type 2 diabetes, puberty, oral glucose tolerance test
- MeSH terms
- Blood Glucose, Growth Disorders, Humans, Insulin Resistance, Insulin-Like Growth Factor I, Obesity, Growth Hormone, Carbohydrate Metabolism
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