The GH-IGF1 axis and longevity: the paradigm of IGF1 deficiency
Open accessAbstract
Primary or secondary IGF1 deficiency has been implicated in shortening of lifespan. This paper reviews available data on the influence of IGF1 deficiency on lifespan and longevity in animals and man. It has been shown that inactivation of the IGF1 gene or of the GH receptor in both invertebrates (C-elegans, flies-Drosphila) and rodents (mice and rats), leading to IGF1 deficiency, prolong life, particularly in females. In man, evaluation of the 2 largest cohorts of patients with Laron syndrome (inactive GH receptor resulting in IGF1 deficiency) in Israel and Ecuador revealed that despite their dwarfism and marked obesity, patients are alive at the ages of 75-78 years, with some having reached even more advanced ages. It is assumed that a major contributing factor is their protection from cancer, a major cause of death in the general population.
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Serum IGF-1 increases with age until puberty and then gradually declines into old age.
“Like GH, serum IGF-1 increases with age until puberty, and then gradually declines into old age (Figure 1C).61, 65”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [65]
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- Authors
- Laron, Z.
- Affiliations
- Tel Aviv University (IL)
- Corresponding author
- Laron, Zvi
- ORCID
- Laron, Zvi
- Venue
- HORMONES
- Published
- 2008-01
- Volume
- 7
- Issue
- 1
- Pages
- 24-27
- ISSN
- 1109-3099 (ISSN-L)
- 2520-8721
- OpenAlex
- W2334256986
- Cited by
- 80
- References
- 35
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 8 · 2017: 7 · 2016: 8 · 2015: 4 · 2014: 5 · 2013: 10 · 2012: 2
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- HORMONES (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- somatotropic axis, longevity, lifespan, Laron syndrome, growth hormone receptor, growth hormone, cancer protection, aging, sex differences, obesity, dwarfism
- MeSH terms
- Humans, Insulin-Like Growth Factor I, Longevity, Neoplasms, Human Growth Hormone, Laron Syndrome
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