Cited by 80Growth Hormone and Insulin-like Growth FactorsGenetics, Aging, and Longevity in Model OrganismsHypothalamic control of reproductive hormones

The GH-IGF1 axis and longevity: the paradigm of IGF1 deficiency

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Laron, Zvi·2008·HORMONES

Abstract

Primary or secondary IGF1 deficiency has been implicated in shortening of lifespan. This paper reviews available data on the influence of IGF1 deficiency on lifespan and longevity in animals and man. It has been shown that inactivation of the IGF1 gene or of the GH receptor in both invertebrates (C-elegans, flies-Drosphila) and rodents (mice and rats), leading to IGF1 deficiency, prolong life, particularly in females. In man, evaluation of the 2 largest cohorts of patients with Laron syndrome (inactive GH receptor resulting in IGF1 deficiency) in Israel and Ecuador revealed that despite their dwarfism and marked obesity, patients are alive at the ages of 75-78 years, with some having reached even more advanced ages. It is assumed that a major contributing factor is their protection from cancer, a major cause of death in the general population.

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Crossref · 10.14310/horm.2002.1111034

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  1. hormone in adults, Cambridge University Press Cam- bridge; pp. 54-86.

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Authors
Laron, Z.
Affiliations
Tel Aviv University (IL)
Corresponding author
Laron, Zvi
Venue
HORMONES
Published
2008-01
Volume
7
Issue
1
Pages
24-27
ISSN
  • 1109-3099 (ISSN-L)
  • 2520-8721
OpenAlex
W2334256986
Cited by
80
References
35
Citations by year
2026: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 8 · 2017: 7 · 2016: 8 · 2015: 4 · 2014: 5 · 2013: 10 · 2012: 2
FWCI
1.01
Type
journal article
Language
en
Open access
Locations
  • HORMONES (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
somatotropic axis, longevity, lifespan, Laron syndrome, growth hormone receptor, growth hormone, cancer protection, aging, sex differences, obesity, dwarfism
MeSH terms
Humans, Insulin-Like Growth Factor I, Longevity, Neoplasms, Human Growth Hormone, Laron Syndrome

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