Cited by 140DNA Repair MechanismsCarcinogens and Genotoxicity AssessmentSkin Protection and Aging

The influence of caffeine on cell survival in excision-proficient and excision-deficient xeroderma pigmentosum and normal human cell strains following ultraviolet-light irradiation

Arlett, C.F., Harcourt, S.A., Broughton, B.C.·1975·Mutation Research

Abstract

A uniform response to UV of four normal cell strains was demonstrated. One excision-proficient xeroderma pigmentosum variant strain (XP7TA) had a wild-type UV response but a second (XP30RO) was more sensitive. An excision-deficient xeroderma pigmentosum strain XP4L0 was substantially more sensitive than wild-type cell strains. A continuous post-irradiation treatment with non-toxic levels of caffeine enhanced the lethal effect of UV light in both xeroderma pigmentosum variant cell strains but not in cells from normal individuals. There was no detectable effect on cells from a xeroderma pigmentosum individual from complementation group A. These results correlate well with observations on the influence of caffeine on post-replication repair in the three classes of cells.

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Crossref · 10.1016/0027-5107(75)90209-2

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14 of 14 references verified0 citation errors · 0 not checkable

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Authors
Arlett, C. F., Harcourt, S. A., & Broughton, B. C.
Affiliations
University of Sussex (GB)
Venue
Mutation Research
Publisher
Elsevier BV
Published
1975-12
Volume
33
Issue
2-3
Pages
341-346
ISSN
0027-5107 (ISSN-L)
OpenAlex
W2001741635
Cited by
140
References
14
Citations by year
2024: 1 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 7 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 4
FWCI
3.51
Type
journal article
Language
en
Open access
closed
Locations
  • Mutation research. Fundamental and molecular mechanisms of mutagenesis (publishedVersion)
  • PubMed (publishedVersion)
Funders
H2020 Euratom
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords
caffeine, xeroderma pigmentosum, ultraviolet radiation, cell survival, excision repair, postreplication repair
MeSH terms
Caffeine, Cell Survival, DNA Repair, Fibroblasts, Humans, Radiation Genetics, Ultraviolet Rays, Xeroderma Pigmentosum

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