Replication of damaged DNA: molecular defect in xeroderma pigmentosum variant cells

Cordonnier, Agnes M; Fuchs, Robert P.P

doi:10.1016/s0921-8777(99)00047-6

Cited by 113DNA Repair MechanismsGenetic factors in colorectal cancerNuclear Structure and Function

Replication of damaged DNA: molecular defect in xeroderma pigmentosum variant cells

Cordonnier, Agnes M, Fuchs, Robert P.P·1999·Mutation Research/DNA Repair

DOI 10.1016/s0921-8777(99)00047-6

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Abstract

Individuals with Xeroderma pigmentosum (XP) syndrome have a genetic predisposition to sunlight-induced skin cancer. Genetically different forms of XP have been identified by cell fusion. Cells of individuals expressing the classical form of XP (complementation groups A through G) are deficient in the nucleotide excision repair (NER) pathway. In contrast, the cells belonging to the variant class of XP (XPV) are NER-proficient and are only slightly more sensitive than normal cells to the killing action of UV light radiation. The XPV fibroblasts replicate damaged DNA generating abnormally short fragments either in vivo [A.R. Lehmann, The relationship between pyramidine dimers and replicating DNA in UV-irradiated human fibroblasts, Nucleic Acids Res. 7 (1979) 1901-1912; S.D. Park, J.E. Cleaver, Postreplication repair: question of its definition and possible alteration in Xeroderma pigmentosum cell strains, Proc. Natl. Acad. Sci. U.S.A. 76 (1979) 3927-3931.] or in vitro [S.M. Cordeiro, L.S. Zaritskaya, L.K. Price, W.K. Kaufmann, Replication fork bypass of a pyramidine dimer blocking leading strand DNA synthesis, J. Biol. Chem. 272 (1997) 13945-13954; D.L. Svoboda, L.P. Briley, J.M. Vos, Defective bypass replication of a leading strand cyclobutane thymine dimer in Xeroderma pigmentosum variant cell extracts, Cancer Res. 58 (1998) 2445-2448; I. Ensch-Simon, P.M. Burgers, J.S. Taylor, Bypass of a site-specific cis-syn thymine dimer in an SV40 vector during in vitro replication by HeLa and XPV cell-free extracts, Biochemistry 37 (1998) 8218-8226.], suggesting that in XPV cells, replication has an increased probability of being blocked at a lesion. Furthermore, extracts from XPV cells were found to be defective in translesion synthesis [A. Cordonnier, A.R. Lehmann, R.P.P. Fuchs, Impaired translesion synthesis in Xeroderma pigmentosum variant extracts, Mol. Cell. Biol. 19 (1999) 2206-2211.]. Recently, Masutani et al. [C. Masutani, M. Araki, A. Yamada, R. Kusomoto, T. Nogimori, T. Maekawa, S. Iwai, F. Hanaoka, Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity, EMBO J. 18 (1999) 3491-3501.] have shown that the XPV defect can be corrected by a novel human DNA polymerase, homologue to the yeast DNA polymerase eta, which is able to replicate past cyclobutane pyrimidine dimers in DNA templates. This review focuses on our current understanding of translesion synthesis in mammalian cells whose defect, unexpectedly, is responsible for the hypermutability of XPV cells and for the XPV pathology.

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Waga, S., Hannon, G. J., Beach, D., & Stillman, B. (1994) · Nature · doi:10.1038/369574a0 · Cited by 1,655 · see citing works
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η
Masutani, C., Kusumoto, R., Yamada, A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M., Iwai, S., Takio, K., & Hanaoka, F. (1999) · Nature · doi:10.1038/21447 · Cited by 1,292 · see citing works
Efficient Bypass of a Thymine-Thymine Dimer by Yeast DNA Polymerase, Polη
Johnson, R. E., Prakash, S., & Prakash, L. (1999) · Science · doi:10.1126/science.283.5404.1001 · Cited by 736 · see citing works
<i>hRAD30</i> Mutations in the Variant Form of Xeroderma Pigmentosum
Johnson, R. E., Kondratick, C. M., Prakash, S., & Prakash, L. (1999) · Science · doi:10.1126/science.285.5425.263 · Cited by 732 · see citing works
Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation
Lehman, A. R., Kirk-Bell, S., Arlett, C. F., Paterson, M. C., Lohman, P. H., de Weerd-Kastelein, E. A., & Bootsma, D. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.1.219 · Cited by 614 · see citing works
Deoxycytidyl transferase activity of yeast REV1 protein
Nelson, J. R., Lawrence, C. W., & Hinkle, D. C. (1996) · Nature · doi:10.1038/382729a0 · Cited by 573 · see citing works
The dinB Gene Encodes a Novel E. coli DNA Polymerase, DNA Pol IV, Involved in Mutagenesis
Wagner, J. E., Grúz, P., Kim, S.-R., Yamada, M., Matsui, K., Fuchs, R. P., & Nohmi, T. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80376-7 · Cited by 474 · see citing works
Self-citation
A model for replication repair in mammalian cells
Higgins, N. P., Kato, K., & Strauss, B. S. (1976) · Journal of Molecular Biology · doi:10.1016/0022-2836(76)90156-x · Cited by 444 · see citing works
Postreplication repair of DNA in ultraviolet-irradiated mammalian cells
Lehmann, A. R. (1972) · Journal of Molecular Biology · doi:10.1016/0022-2836(72)90418-4 · Cited by 437 · see citing works
Xeroderma pigmentosum variant (XP‐V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity
Masutani, C., Araki, M., Yamada, A., Kusumoto, R., Nogimori, T., Maekawa, T., Iwai, S., & Hanaoka, F. (1999) · The EMBO Journal · doi:10.1093/emboj/18.12.3491 · Cited by 434 · see citing works
Multiple pathways for SOS-induced mutagenesis in Escherichia coli: an overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA.
Kim, S.-R., Maenhaut-Michel, G., Yamada, M., Yamamoto, Y., Matsui, K., Sofuni, T., Nohmi, T., & Ohmori, H. (1997) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.94.25.13792 · Cited by 343 · see citing works
Frequency of ultraviolet light-induced mutations is higher in xeroderma pigmentosum variant cells than in normal human cells
MAHER, V. M., OUELLETTE, L. M., CURREN, R. D., & MCCORMICK, J. J. (1976) · Nature · doi:10.1038/261593a0 · Cited by 333 · see citing works
The Saccharomyces cerevisiae RAD30 Gene, a Homologue of Escherichia coli dinB and umuC, Is DNA Damage Inducible and Functions in a Novel Error-Free Postreplication Repair Mechanism
McDonald, J. P., Levine, A. S., & Woodgate, R. (1997) · Genetics · doi:10.1093/genetics/147.4.1557 · Cited by 314 · see citing works
A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase ζ
Gibbs, P., McGregor, W. G., Maher, V. M., Nisson, P. E., & Lawrence, C. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6876 · Cited by 301 · see citing works
Restricted ultraviolet mutational spectrum in a shuttle vector propagated in xeroderma pigmentosum cells.
Bredberg, A. C. A., Kraemer, K. H., & Seidman, M. M. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.21.8273 · Cited by 214 · see citing works
Persistence of pyrimidine dimers during post-replication repair in ultraviolet light-irradiated Escherichia coli K12
Ganesan, A. K. (1974) · Journal of Molecular Biology · doi:10.1016/0022-2836(74)90563-4 · Cited by 209 · see citing works
Activity of the purified mutagenesis proteins UmuC, UmuD', and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase III.
Rajagopalan, M. R., Lu, C., Woodgate, R., O’Donnell, M. E., Goodman, M. F., & Echols, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10777 · Cited by 203 · see citing works
UV light‐induced DNA synthesis arrest in HeLa cells is associated with changes in phosphorylation of human single‐stranded DNA‐binding protein.
Carty, M. P., Zernik-Kobak, M., McGrath, S., & Dixon, K. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06487.x · Cited by 186 · see citing works
DNA polymerase zeta and the control of DNA damage induced mutagenesis in eukaryotes.
Lawrence, C. W., & Hinkle, D. C. (1996) · PubMed · Cited by 166 · see citing works
Sequence Specificity of Point Mutations Induced During Passage of a UV-Irradiated Shuttle Vector Plasmid in Monkey Cells
Hauser, J. M., Seidman, M. M., Sidur, K., & Dixon, K. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.1.277 · Cited by 164 · see citing works
Evidence from Mutation Spectra that the UV Hypermutability of Xeroderma Pigmentosum Variant Cells Reflects Abnormal, Error-Prone Replication on a Template Containing Photoproducts
Wang, Y., Maher, V. M., Mitchell, D. L., & McCormick, J. J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.4276 · Cited by 161 · see citing works
The influence of caffeine on cell survival in excision-proficient and excision-deficient xeroderma pigmentosum and normal human cell strains following ultraviolet-light irradiation
Arlett, C. F., Harcourt, S. A., & Broughton, B. C. (1975) · Mutation Research · doi:10.1016/0027-5107(75)90209-2 · Cited by 140 · see citing works
Deletion of the Saccharomyces cerevisiae gene RAD30 encoding an Escherichia coli DinB homolog confers UV radiation sensitivity and altered mutability
Roush, A. A., Suarez, M., Friedberg, E. C., Radman, M., & Siede, W. (1998) · Molecular and General Genetics MGG · doi:10.1007/s004380050698 · Cited by 135 · see citing works
Replication Fork Bypass of a Pyrimidine Dimer Blocking Leading Strand DNA Synthesis
Cordeiro‐Stone, M., Zaritskaya, L., Price, L. K., & Kaufmann, W. K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.21.13945 · Cited by 123 · see citing works
Novel DNA Polymerases Offer Clues to the Molecular Basis of Mutagenesis
Friedberg, E. C., & Gerlach, V. L. (1999) · Cell · doi:10.1016/s0092-8674(00)81970-4 · Cited by 121 · see citing works
Differential replication of a single, UV-induced lesion in the leading or lagging strand by a human cell extract: fork uncoupling or gap formation.
Svoboda, D. L., & Vos, J. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.11975 · Cited by 111 · see citing works
Requirement of DNA Polymerase Activity of Yeast Rad30 Protein for Its Biological Function
Johnson, R. E., Prakash, S., & Prakash, L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.15975 · Cited by 106 · see citing works
Yeast DNA repair protein RAD5 that promotes instability of simple repetitive sequences is a DNA-dependent ATPase.
Johnson, R. E., Prakash, S., & Prakash, L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46922-0 · Cited by 105 · see citing works
T4-endonuclease V-sensitive sites in DNA from ultraviolet-irradiated human cells
Meneghini, R., & Hanawalt, P. C. (1976) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(76)90007-1 · Cited by 102 · see citing works
Analysis of DNA replication forks encountering a pyrimidine dimer in the template to the leading strand 1 1Edited by M. Yaniv
Cordeiro‐Stone, M., Makhov, A. M., Zaritskaya, L., & Griffith, J. D. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.2847 · Cited by 102 · see citing works
Postreplication repair: questions of its definition and possible alteration in xeroderma pigmentosum cell strains.
Park, S. D., & Cleaver, J. E. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.8.3927 · Cited by 98 · see citing works
Replication of ultraviolet-irradiated simian virus 40 in monkey kidney cells
Sarasin, A. R., & Hanawalt, P. C. (1980) · Journal of Molecular Biology · doi:10.1016/0022-2836(80)90288-0 · Cited by 86 · see citing works
Analysis of Damage Tolerance Pathways in Saccharomyces cerevisiae: a Requirement for Rev3 DNA Polymerase in Translesion Synthesis
Baynton, K., Roy, A. K., & Fuchs, R. P. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.2.960 · Cited by 81 · see citing works
Self-citation
Impaired Translesion Synthesis in Xeroderma Pigmentosum Variant Extracts
Cordonnier, A. M., Lehmann, A. R., & Fuchs, R. P. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.2206 · Cited by 77 · see citing works
Self-citation
Ultraviolet mutagenesis of normal and xeroderma pigmentosum variant human fibroblasts
Myhr, B., Turnbull, D., & DiPaolo, J. A. (1979) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(79)90089-7 · Cited by 76 · see citing works
Xeroderma pigmentosum variant cells are less likely than normal cells to incorporate dAMP opposite photoproducts during replication of UV-irradiated plasmids.
Wang, Y., Maher, V. M., & McCormick, J. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7810 · Cited by 71 · see citing works
Yeast ARS function and nuclear matrix association coincide in a short sequence from the human HPRT locus
Sykes, R. C., Lin, D., Hwang, S., Framson, P. E., & Chinault, A. C. (1988) · Molecular and General Genetics MGG · doi:10.1007/bf00334700 · Cited by 70 · see citing works
Defective postreplication repair in xeroderma pigmentosum variant fibroblasts.
Boyer, J. C., Kaufmann, W. K., Brylawski, B. P., & Cordeiro‐Stone, M. (1990) · PubMed · Cited by 69 · see citing works
Abnormal, Error-Prone Bypass of Photoproducts by Xeroderma Pigmentosum Variant Cell Extracts Results in Extreme Strand Bias for the Kinds of Mutations Induced by UV Light
McGregor, W. G., Dong, W., Maher, V. M., & McCormick, J. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.147 · Cited by 67 · see citing works
Identification of novel interaction partners for the conserved membrane proximal region of α‐integrin cytoplasmic domains
Wixler, V., Laplantine, E., Geerts, D., Sonnenberg, A., Petersohn, D., Eckes, B., Paulsson, M., & Aumailley, M. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00151-9 · Cited by 63 · see citing works
Distinct roles for Rev1p and Rev7p during translesion synthesis in Saccharomyces cerevisiae
Baynton, K., Bresson‐Roy, A., & Fuchs, R. P. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01583.x · Cited by 63 · see citing works
Self-citation
Replication and Mutagenesis of UV-Damaged DNA Templates in Human and Monkey Cell Extracts
Carty, M. P., Hauser, J. M., Levine, A. S., & Dixon, K. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.533 · Cited by 61 · see citing works
Translesion DNA synthesis in the dihydrofolate reductase domain of UV-irradiated CHO cells
Spivak, G., & Hanawalt, P. C. (1992) · Biochemistry · doi:10.1021/bi00144a021 · Cited by 56 · see citing works
Defective bypass replication of a leading strand cyclobutane thymine dimer in xeroderma pigmentosum variant cell extracts.
Svoboda, D. L., Briley, L. P., & Vos, J. H. (1998) · PubMed · Cited by 55 · see citing works
Complete Replication of Plasmid DNA Containing a Single UV-induced Lesion in Human Cell Extracts
Carty, M. P., Lawrence, C. W., & Dixon, K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9637 · Cited by 53 · see citing works
SOS factors involved in translesion synthesis
Napolitano, R. L., Lambert, I. B., & Fuchs, R. P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5733 · Cited by 52 · see citing works
Self-citation
Pyrimidine dimers block simian virus 40 replication forks.
Berger, C. A., & Edenberg, H. J. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.10.3443 · Cited by 51 · see citing works
Synergistic effect of caffeine on the cytotoxicity of ultraviolet irradiation and of hydrocarbon epoxides in strains of Xeroderma pigmentosum
Maher, V. M., Ouellette, L. M., MITTLESTAT, M., & McCormick, J. J. (1975) · Nature · doi:10.1038/258760a0 · Cited by 51 · see citing works
Defective Replication of Psoralen Adducts Detected at the Gene-Specific Level in Xeroderma Pigmentosum Variant Cells
Misra, R. R., & Vos, J. H. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.2.1002-1012.1993 · Cited by 44 · see citing works
The relationship between pyrimidine dimers and replicating DNA in UV-irradiated human fibro-blasts
Lehmann, A. R. (1979) · Nucleic Acids Research · doi:10.1093/nar/7.7.1901 · Cited by 44 · see citing works
Defective and enhanced postreplication repair in classical and variant xeroderma pigmentosum cells treated with N-acetoxy-2-acetylaminofluorene.
D’Ambrosio, S. M., & Setlow, R. B. (1978) · PubMed · Cited by 44 · see citing works
Specific in vivo protein-protein interactions between Escherichia coli SOS mutagenesis proteins
Jonczyk, P., & Nowicka, A. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.9.2580-2585.1996 · Cited by 42 · see citing works
Abnormal sensitivity of human fibroblasts from xeroderma pigmentosum variants to transformation to anchorage independence by ultraviolet radiation.
McCormick, J. J., Kohler, S. K., Watanabe, M., & Maher, V. M. (1986) · PubMed · Cited by 41 · see citing works
Mutagenic replication in human cell extracts of DNA containing site-specific N-2-acetylaminofluorene adducts.
Thomas, D. C., Veaute, X., Kunkel, T. A., & Fuchs, R. P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7752 · Cited by 40 · see citing works
Self-citation
A umuDC-independent SOS pathway for frameshift mutagenesis
Maenhaut-Michel, G., Janel‐Bintz, R., & Fuchs, R. P. (1992) · Molecular and General Genetics MGG · doi:10.1007/bf00279383 · Cited by 38 · see citing works
Self-citation
Relative probability of mutagenic translesion synthesis on the leading and lagging strands during replication of UV-irradiated DNA in a human cell extract
Thomas, D. C., Nguyen, D. C., Piegorsch, W. W., & Kunkel, T. A. (1993) · Biochemistry · doi:10.1021/bi00094a002 · Cited by 35 · see citing works
Recombination of parent and daughter strand DNA after UV-irradiation in mammalian cells
Fornace, A. J. (1983) · Nature · doi:10.1038/304552a0 · Cited by 34 · see citing works
Bypass of a Site-Specific Cis-Syn Thymine Dimer in an SV40 Vector during in Vitro Replication by HeLa and XPV Cell-Free Extracts
Ensch-Simon, I., Burgers, P., & Taylor, J. (1998) · Biochemistry · doi:10.1021/bi972460j · Cited by 33 · see citing works
Frequency and Fidelity of Translesion Synthesis of Site-specific N-2-Acetylaminofluorene Adducts during DNA Replication in a Human Cell Extract
Thomas, D. C., Veaute, X., Fuchs, R. P., & Kunkel, T. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.36.21226 · Cited by 27 · see citing works
Self-citation
Postreplication repair in Saccharomyces cerevisiae
Resnick, M. A., Boyce, J. M., & Cox, B. S. (1981) · Journal of Bacteriology · doi:10.1128/jb.146.1.285-290.1981 · Cited by 27 · see citing works
Inactivation of DNA proofreading obviates the need for SOS induction in frameshift mutagenesis
Fuchs, R. P., & Napolitano, R. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13114 · Cited by 26 · see citing works
Self-citation
Strand Specificity of Mutagenic Bypass Replication of DNA Containing Psoralen Monoadducts in a Human Cell Extract
Thomas, D. C., Svoboda, D. L., Vos, J. H., & Kunkel, T. A. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2537 · Cited by 25 · see citing works
Accommodation of pyrimidine dimers during replication of UV-damaged simian virus 40 DNA.
Stacks, P. C., White, J. H., & Dixon, K. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.8.1403 · Cited by 20 · see citing works
Differential Replication of a SingleN-2-Acetylaminofluorene Lesion in the Leading or Lagging Strand DNA in a Human Cell Extract
Veaute, X., & Sarasin, A. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15351 · Cited by 16 · see citing works
Xeroderma pigmentosum variant and normal fibroblasts show the same response to the inhibition of DNA replication by benzo[a] pyrene-diol-epoxide-I
Cordeiro‐Stone, M., Boyer, J. C., Smith, B. A., & Kaufmann, W. K. (1986) · Carcinogenesis · doi:10.1093/carcin/7.10.1783 · Cited by 14 · see citing works

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Mechanisms of accurate translesion synthesis by human DNA polymerase η
Masutani, C., Kusumoto, R., Iwai, S., & Hanaoka, F. (2000) · The EMBO Journal · doi:10.1093/emboj/19.12.3100 · Cited by 504 · see citing works
All three SOS‐inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesis
Napolitano, R. L., Janel‐Bintz, R., Wagner, J. E., & Fuchs, R. P. (2000) · The EMBO Journal · doi:10.1093/emboj/19.22.6259 · Cited by 403 · see citing works
Self-citation
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Ohashi, E., Ogi, T., Kusumoto, R., Iwai, S., Masutani, C., Hanaoka, F., & Ohmori, H. (2000) · Genes & Development · doi:10.1101/gad.14.13.1589 · Cited by 282 · see citing works
How DNA lesions are turned into mutations within cells?
Pagès, V., & Fuchs, R. P. (2002) · Oncogene · doi:10.1038/sj.onc.1206006 · Cited by 237 · see citing works
Self-citation
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Kawamoto, T., Araki, K., Sonoda, E., Yamashita, Y. M., Harada, K. H., Kikuchi, K., Masutani, C., Hanaoka, F., Nozaki, K., Hashimoto, N., et al. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.10.016 · Cited by 231 · see citing works
Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the β‐clamp
Bunting, K. A., Roe, S. M., & Pearl, L. H. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg568 · Cited by 225 · see citing works
Co-localization in replication foci and interaction of human Y-family members, DNA polymerase polη and REVl protein
Tissier, A., Kannouche, P. L., Reck, M.-P., Lehmann, A. R., Fuchs, R. P., & Cordonnier, A. M. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.06.015 · Cited by 207 · see citing works
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Managing DNA polymerases: Coordinating DNA replication, DNA repair, and DNA recombination
Sutton, M. D., & Walker, G. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111036998 · Cited by 184 · see citing works
DNA Damage in the Nucleosome Core Is Refractory to Repair by Human Excision Nuclease
Hara, R., Mo, J., & Sancar, A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.24.9173-9181.2000 · Cited by 184 · see citing works
Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations
He, J., Qiu, L., Wang, M., Hua, R., Zhang, R.-X., Yu, H.-P., Wang, Y.-N., Sun, M.-H., Zhou, X.-Y., Yang, Y.-J., et al. (2012) · Human Genetics · doi:10.1007/s00439-012-1152-8 · Cited by 177 · see citing works
Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation
Rapić-Otrin, V. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.11.2588 · Cited by 171 · see citing works
The β clamp targets DNA polymerase IV to DNA and strongly increases its processivity
Wagner, J. E., 藤井, 慎., Grúz, P., Nohmi, T., & Fuchs, R. P. (2000) · EMBO Reports · doi:10.1093/embo-reports/kvd109 · Cited by 168 · see citing works
Self-citation
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Wagner, J. E., & Nohmi, T. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.16.4587-4595.2000 · Cited by 159 · see citing works
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Arnould, S., Perez, C., Cabaniols, J., Smith, J. N. P., Gouble, A., Grizot, S., Epinat, J.-C., Duclert, A., Duchateau, P. N., & Pâques, F. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.04.079 · Cited by 141 · see citing works
PCNA Modifications for Regulation of Post-Replication Repair Pathways
Lee, K., & Myung, K. (2008) · Molecules and Cells · doi:10.1016/s1016-8478(23)13956-2 · Cited by 141 · see citing works
Human Telomeres Are Hypersensitive to UV-Induced DNA Damage and Refractory to Repair
Rochette, P. J., & Brash, D. E. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000926 · Cited by 133 · see citing works
Defining the position of the switches between replicative and bypass DNA polymerases
藤井, 慎., & Fuchs, R. P. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600438 · Cited by 132 · see citing works
Self-citation
Pivotal role of the β-clamp in translesion DNA synthesis and mutagenesis in E. coli cells
Bécherel, O. J. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00106-4 · Cited by 129 · see citing works
Translocation of Cockayne syndrome group A protein to the nuclear matrix: Possible relevance to transcription-coupled DNA repair
Kamiuchi, S., Saijo, M., Citterio, E., de Jager, M., Hoeijmakers, J. H. J., & Tanaka, K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012473199 · Cited by 129 · see citing works
A Water-Mediated and Substrate-Assisted Catalytic Mechanism forSulfolobus solfataricusDNA Polymerase IV
Wang, L., Yu, X., Hu, P., Broyde, S. B., & Zhang, Y. (2007) · Journal of the American Chemical Society · doi:10.1021/ja068821c · Cited by 124 · see citing works
DNA Damage Control by Novel DNA Polymerases: Translesion Replication and Mutagenesis
Livneh, Z. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100019200 · Cited by 119 · see citing works
Altered DNA Polymerase ι Expression in Breast Cancer Cells Leads to a Reduction in DNA Replication Fidelity and a Higher Rate of Mutagenesis
Jin, Y., Chen, Z., Liu, Y., Hickey, R. J., & Malkas, L. H. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0603 · Cited by 115 · see citing works
Structural and Biochemical Analysis of Sliding Clamp/Ligand Interactions Suggest a Competition Between Replicative and Translesion DNA Polymerases
Burnouf, D., Oliéric, V., Wagner, J. E., 藤井, 慎., Reinbolt, J., Fuchs, R. P., & Dumas, P. (2003) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.11.049 · Cited by 111 · see citing works
Self-citation
Quantitative measurement of translesion replication in human cells: Evidence for bypass of abasic sites by a replicative DNA polymerase
Avkin, S., Adar, S., Blander, G., & Livneh, Z. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062038699 · Cited by 112 · see citing works
Mechanisms of tandem repeat instability in bacteria
Bichara, M., Wagner, J. E., & Lambert, I. B. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.01.020 · Cited by 103 · see citing works
Properties and Functions of Escherichia Coli: Pol IV and Pol V
Fuchs, R. P., Fujii, S., & Wagner, J. (2004) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(04)69008-5 · Cited by 100 · see citing works
Self-citation
The genetics of the hereditary xeroderma pigmentosum syndrome
Stary, A., & Sarasin, A. R. (2002) · Biochimie · doi:10.1016/s0300-9084(01)01358-x · Cited by 94 · see citing works
Involvement of Vertebrate Polκ in Rad18-independent Postreplication Repair of UV Damage
Okada, T., Sonoda, E., Yamashita, Y. M., Koyoshi, S., Tateishi, S., Yamaizumi, M., Takata, M., Ogawa, O., & Takeda, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207957200 · Cited by 92 · see citing works
Proliferating Cell Nuclear Antigen-dependent Coordination of the Biological Functions of Human DNA Polymerase ι
Vidal, A. E., Kannouche, P. L., Podust, V. N., Yang, W., Lehmann, A. R., & Woodgate, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406511200 · Cited by 90 · see citing works
Genetics of mutagenesis in E. coli: various combinations of translesion polymerases (Pol II, IV and V) deal with lesion/sequence context diversity
Wagner, J. E., Etienne, H., Janel‐Bintz, R., & Fuchs, R. P. (2002) · DNA repair · doi:10.1016/s1568-7864(01)00012-x · Cited by 88 · see citing works
Self-citation
Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase
Yamada, A., Masutani, C., Iwai, S., & Hanaoka, F. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.13.2473 · Cited by 88 · see citing works
PSI-BLAST searches using hidden Markov models of structural repeats: prediction of an unusual sliding DNA clamp and of beta-propellers in UV-damaged DNA-binding protein
Neuwald, A. F. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.18.3570 · Cited by 81 · see citing works
Unraveling DNA Repair in Human: Molecular Mechanisms and Consequences of Repair Defect
Tuteja, N. K., & Tuteja, R. (2001) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/20014091074192 · Cited by 79 · see citing works
Tolerance of dividing cells to replication stress in UVB-irradiated Arabidopsis roots: Requirements for DNA translesion polymerases η and ζ
Curtis, M. J., & Hays, J. B. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.03.004 · Cited by 80 · see citing works
The Biochemical Requirements of DNA Polymerase V-mediated Translesion Synthesis Revisited
藤井, 慎., Gasser, V., & Fuchs, R. P. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.06.017 · Cited by 75 · see citing works
Self-citation
Observing Translesion Synthesis of an Aromatic Amine DNA Adduct by a High-fidelity DNA Polymerase
Hsu, G. W., Kiefer, J. R., Burnouf, D., Bécherel, O. J., Fuchs, R. P., & Beese, L. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409224200 · Cited by 72 · see citing works
Self-citation
Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome
Quinet, A., Vessoni, A. T., Rocha, C. R. R., Gottifredi, V., Biard, D., Sarasin, A., Menck, C. F. M., & Stary, A. (2014) · DNA Repair · doi:10.1016/j.dnarep.2013.12.005 · Cited by 70 · see citing works
Four radiation hypersensitivity cases and their implications for clinical radiotherapy
Rogers, P. B., Plowman, P. N., Harris, S., & Arlett, C. F. (2000) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(00)00249-8 · Cited by 68 · see citing works
The processing of a Benzo(a)pyrene adduct into a frameshift or a base substitution mutation requires a different set of genes in Escherichia coli
Lenne‐Samuel, N., Janel‐Bintz, R., Kolbanovskiy, A., Geacintov, N. E., & Fuchs, R. P. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.02116.x · Cited by 68 · see citing works
Self-citation
The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability
Sharma, S., Helchowski, C. M., & Canman, C. E. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2012.11.002 · Cited by 71 · see citing works
Aging: not all DNA damage is equal
Vermeij, W. P., Hoeijmakers, J. H. J., & Pothof, J. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.06.006 · Cited by 68 · see citing works
A Role for DNA Polymerase β in Mutagenic UV Lesion Bypass
Servant, L., Cazaux, C., Bieth, A., Iwai, S., Hanaoka, F., & Hoffmann, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207101200 · Cited by 64 · see citing works
Xeroderma pigmentosum variant and error-prone DNA polymerases
Kannouche, P. (2003) · Biochimie · doi:10.1016/j.biochi.2003.10.009 · Cited by 60 · see citing works
Translesion DNA synthesis in the context of cancer research
Knobel, P. A., & Marti, T. M. (2011) · Cancer Cell International · doi:10.1186/1475-2867-11-39 · Cited by 64 · see citing works
In Vitro (CTG)·(CAG) Expansions and Deletions by Human Cell Extracts
Panigrahi, G. B., Cleary, J. D., & Pearson, C. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109761200 · Cited by 59 · see citing works
Inhibition of Nucleotide Excision Repair by High Mobility Group Protein HMGA1
Adair, J. E., Kwon, Y., Dement, G. A., Smerdon, M. J., & Reeves, R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505600200 · Cited by 57 · see citing works
Mutations in human DNA polymerase η motif II alter bypass of DNA lesions
Glick, E., Vigna, K. L., & Loeb, L. A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.7303 · Cited by 54 · see citing works
Synthetic Activity of Sso DNA Polymerase Y1, an Archaeal DinB-like DNA Polymerase, Is Stimulated by Processivity Factors Proliferating Cell Nuclear Antigen and Replication Factor C
Grúz, P., Pisani, F. M., Shimizu, M., Yamada, M., Hayashi, I., Morikawa, K., & Nohmi, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107213200 · Cited by 55 · see citing works
Send in the Clamps: Control of DNA Translesion Synthesis in Eukaryotes
Jansen, J. G., Fousteri, M. I., & de Wind, N. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.11.005 · Cited by 55 · see citing works
Replication of UV-damaged DNA: new insights into links between DNA polymerases, mutagenesis and human disease
Lehmann, A. R. (2000) · Gene · doi:10.1016/s0378-1119(00)00250-x · Cited by 52 · see citing works
DNA excision repair at telomeres
Jia, P., Her, C., & Chai, W. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.09.017 · Cited by 51 · see citing works
Genetic and epigenetic features in radiation sensitivity
Bourguignon, M., Gisone, P. A., Perez, M. R., Michelin, S., Dubner, D., Giorgio, M. D., & Carosella, E. D. (2005) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-004-1731-6 · Cited by 47 · see citing works
A method to monitor replication fork progression in mammalian cells: nucleotide excision repair enhances and homologous recombination delays elongation along damaged DNA
Johansson, F. (2004) · Nucleic Acids Research · doi:10.1093/nar/gnh154 · Cited by 40 · see citing works
Human Variation in DNA Repair, Immune Function, and Cancer Risk
Cheong, A. W. Y., & Nagel, Z. D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.899574 · Cited by 36 · see citing works
Genetic variants in the nucleotide excision repair pathway genes and gastric cancer susceptibility in a southern Chinese population
He, J., Zhuo, Z., Zhang, A., Zhu, J., Hua, R., Xue, W., Zhang, S.-D., Zhang, J., Li, X., & Jia, W. (2018) · Cancer Management and Research · doi:10.2147/cmar.s160080 · Cited by 37 · see citing works
Translesion DNA Synthesis by Yeast DNA Polymerase η on Templates Containing N 2-Guanine Adducts of 1,3-Butadiene Metabolites
Minko, I. G., Washington, M. T., Prakash, L., Prakash, S., & Lloyd, R. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007867200 · Cited by 37 · see citing works
Association between genetic variants in the XPG gene and gastric cancer risk in a Southern Chinese population
Hua, R., Zhuo, Z., Zhu, J., Jiang, D.-H., Xue, W., Zhang, S.-D., Zhang, J., Li, X., Zhang, P., Jia, W.-H., et al. (2016) · Aging · doi:10.18632/aging.101119 · Cited by 34 · see citing works
Characterization of a Y‐Family DNA Polymerase eta from the Eukaryotic Thermophile Alvinella pompejana
Kashiwagi, S., Kuraoka, I., Fujiwara, Y., Hitomi, K., Cheng, Q. J., Fuss, J. O., Shin, D. S., Masutani, C., Tainer, J. A., Hanaoka, F., et al. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/701472 · Cited by 33 · see citing works
Regulation of HLTF-mediated PCNA polyubiquitination by RFC and PCNA monoubiquitination levels determines choice of damage tolerance pathway
Masuda, Y., Mitsuyuki, S., Kanao, R., Hishiki, A., Hashimoto, H., & Masutani, C. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky943 · Cited by 31 · see citing works
Synthetic Nucleotides as Probes of DNA Polymerase Specificity
Walsh, J. M., & Beuning, P. J. (2012) · Journal of Nucleic Acids · doi:10.1155/2012/530963 · Cited by 26 · see citing works
Kinetic Basis for the Differing Response to an Oxidative Lesion by a Replicative and a Lesion Bypass DNA Polymerase from Sulfolobus solfataricus
Maxwell, B. A., & Suo, Z. (2012) · Biochemistry · doi:10.1021/bi300246r · Cited by 25 · see citing works
Effects of non‐catalytic, distal amino acid residues on activity of E. coli DinB (DNA polymerase IV)
Walsh, J. M., Parasuram, R., Rajput, P. R., Rozners, E., Ondrechen, M. J., & Beuning, P. J. (2012) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21730 · Cited by 25 · see citing works
Xeroderma Pigmentosum Variant: From a Human Genetic Disorder to a Novel DNA PolymerasePreprint
Masutani, C., Kusumoto, R., Yamada, A., Yuasa, M., Araki, M., Nogimori, T., Yokoi, M., Eki, T., Iwai, S., & Hanaoka, F. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.71 · Cited by 24 · see citing works
Effects of Accessory Proteins on the Bypass of a cis-syn Thymine−Thymine Dimer by Saccharomyces cerevisiae DNA Polymerase η
McCulloch, S. D., Wood, A., Garg, P., Burgers, P., & Kunkel, T. A. (2007) · Biochemistry · doi:10.1021/bi700234t · Cited by 23 · see citing works
Polymorphisms in the XPC gene and gastric cancer susceptibility in a Southern Chinese population
He, J., Hua, R., Zhuo, Z., Shen, G., Zhu, J., Zhang, S., Xue, W., Li, X., Zhang, P., & Jia, W. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s113055 · Cited by 21 · see citing works
Ubiquitylation of Proliferating Cell Nuclear Antigen and Recruitment of Human DNA Polymerase η
Nikolaishvili‐Feinberg, N., Jenkins, G. S., Nevis, K. R., Staus, D. P., Scarlett, C. O., Ünsal-Kaçmaz, K., Kaufmann, W. K., & Cordeiro‐Stone, M. (2008) · Biochemistry · doi:10.1021/bi702329h · Cited by 20 · see citing works
Mutagenic nucleotide incorporation and hindered translocation by a food carcinogen C8-dG adduct in Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): modeling and dynamics studies
Zhang, L. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl425 · Cited by 20 · see citing works
XPG is Predictive Gene of Clinical Outcome in Advanced Non-small-cell Lung Cancer with Platinum Drug Therapy
Zhang, T., Sun, J., Lv, M., Zhang, L., Wang, X., Ren, J.-C., & Wang, B. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.2.701 · Cited by 19 · see citing works
XPG is a novel biomarker of clinical outcome in advanced non-small-cell lung cancer
Yi, Y., & Zhe, S. (2013) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.293.3664 · Cited by 18 · see citing works
The Fidelity of HPV16 E1/E2-mediated DNA Replication
Taylor, E. R., Dornan, E. S., Boner, W., Connolly, J. A., McNair, S., Kannouche, P. L., Lehmann, A. R., & Morgan, I. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308779200 · Cited by 18 · see citing works
Asymmetry of DNA replication and translesion synthesis of UV-induced thymine dimers
Cordeiro‐Stone, M., & Nikolaishvili‐Feinberg, N. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00255-5 · Cited by 17 · see citing works
Decreased UV sensitivity, mismatch repair activity and abnormal cell cycle checkpoints in skin cancer cell lines derived from UVB-irradiated XPA-deficient mice
Ichikawa, M., Nakane, H., Marra, G., Corti, C., Jiricny, J., Fitch, M., Ford, J. M., Ikejima, M., Shimada, T., Yoshino, M., et al. (2000) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(00)00005-7 · Cited by 18 · see citing works
Accommodation of a 1S-(−)-Benzo[c]phenanthrenyl-N6-dA Adduct in the Y-Family Dpo4 DNA Polymerase Active Site: Structural Insights through Molecular Dynamics Simulations
Wang, L., Wu, M., Yan, S. F., Patel, D. J., Geacintov, N. E., & Broyde, S. B. (2005) · Chemical Research in Toxicology · doi:10.1021/tx049786v · Cited by 17 · see citing works
Molecular mechanisms of UV-induced mutations as revealed by the study of DNA polymerase η in human cells
Stary, A., & Sarasin, A. R. (2002) · Research in Microbiology · doi:10.1016/s0923-2508(02)01343-8 · Cited by 17 · see citing works
The noncatalytic C‐terminus of AtPOLK Y‐family DNA polymerase affects synthesis fidelity, mismatch extension and translesion replication
García‐Ortiz, M. V., Roldán‐Arjona, T., & Ariza, R. R. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05868.x · Cited by 16 · see citing works
Hereditary Disorders with Defective Repair of UV-Induced DNA Damage
Moriwaki, S. (2013) · Japanese Clinical Medicine · doi:10.4137/jcm.s10730 · Cited by 14 · see citing works
Electrical Current Signatures of DNA Base Modifications in Single Molecules Immobilized in the α‐Hemolysin Ion Channel
Wolna, A. H., Fleming, A. M., An, N., He, L., White, H. S., & Burrows, C. J. (2013) · Israel Journal of Chemistry · doi:10.1002/ijch.201300022 · Cited by 13 · see citing works
Phosphorylation Alters the Properties of Pol η: Implications for Translesion Synthesis
Peddu, C., Zhang, S., Zhao, H. L., Wong, A., Lee, E. Y. C., Lee, M., & Zhang, Z. (2018) · iScience · doi:10.1016/j.isci.2018.07.009 · Cited by 13 · see citing works
Binding of Zinc Finger Protein Transcription Factor IIIA to Its Cognate DNA Sequence with Single UV Photoproducts at Specific Sites and Its Effect on DNA Repair
Kwon, Y., & Smerdon, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308645200 · Cited by 13 · see citing works
Caracterização genotípica de pacientes brasileiros com deficiência em processos de reparo de DNA.
Castro, L. P. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.87.2017.tde-22022017-155133 · Cited by 13 · see citing works
Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigen K164R mutant mice
Langerak, P., Krijger, P. H. L., Heideman, M. R., van den Berk, P. C. M., & Jacobs, H. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0223 · Cited by 12 · see citing works
Oncolytic Vaccinia virus safely and effectively treats skin tumors in mouse models of xeroderma pigmentosum
Brun, J., Mahoney, D. J., Bœuf, F. L., Lefebvre, C. A., Sanaei, C. A., Falls, T. J., McCart, J. A., & Stojdl, D. F. (2012) · International Journal of Cancer · doi:10.1002/ijc.27695 · Cited by 11 · see citing works
ATR/Chk1 Pathway is Activated by Oxidative Stress in Response to UVA Light in Human Xeroderma Pigmentosum Variant Cells
Moreno, N. C., Garcia, C. C. M., Rocha, C. R. R., Munford, V., & Menck, C. F. M. (2018) · Photochemistry and Photobiology · doi:10.1111/php.13041 · Cited by 9 · see citing works
Investigation on the role of XPG gene polymorphisms in breast cancer risk in a Chinese population
Ma, S., Ling, F. H., Sun, Y. X., Chen, S. F., & Li, Z. (2016) · Genetics and Molecular Research · doi:10.4238/gmr.15028066 · Cited by 8 · see citing works
The Saccharomyces cerevisiae mitochondrial DNA polymerase and its contribution to the knowledge about human POLG ‐related disorders
Gilea, A. I., Magistrati, M., Notaroberto, I., Tiso, N., Dallabona, C., & Baruffini, E. (2023) · IUBMB Life · doi:10.1002/iub.2770 · Cited by 10 · see citing works
Utility of DNA postreplication repair protein Rad6B in neoadjuvant chemotherapy response
Shekhar, M. P. V., Biernat, L. A., Pernick, N. L., Tait, L. R., Abrams, J., & Visscher, D. W. (2009) · Medical Oncology · doi:10.1007/s12032-009-9235-7 · Cited by 8 · see citing works
Functional Insights Gained from Structural Analyses of DNA Duplexes that Contain UV‐Damaged Photoproducts†
Park, C., Lee, J., & Choi, B. (2006) · Photochemistry and Photobiology · doi:10.1562/2006-02-28-ir-820 · Cited by 8 · see citing works
Age and insulin-like growth factor-1 impact PCNA monoubiquitination in UVB-irradiated human skin
Hutcherson, R. J., Gabbard, R. D., Castellanos, A. J., Travers, J. B., & Kemp, M. G. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100570 · Cited by 8 · see citing works
Insulin‐like Growth Factor‐1 Impacts p53 Target Gene Induction in UVB‐irradiated Keratinocytes and Human Skin
Alkawar, A. M. M., Castellanos, A. J., Carpenter, M. A., Hutcherson, R. J., Madkhali, M. A. O., Johnson, R. M., Bottomley, M. A., & Kemp, M. G. (2020) · Photochemistry and Photobiology · doi:10.1111/php.13279 · Cited by 7 · see citing works
The DNA-instability test as a specific marker of malignancy and its application to detect cancer clones in borderline malignancy
Fukuda, M., & Sun, A. (2009) · European Journal of Histochemistry · doi:10.4081/922 · Cited by 7 · see citing works
Association between the XPG gene rs2094258 polymorphism and risk of gastric cancer
Zhang, Z., Yin, J., Xu, Q., & Shi, J. (2018) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.22564 · Cited by 7 · see citing works
Chemotherapeutic intervention by inhibiting DNA polymerases
Dasari, A., Choi, J.-S., & Berdis, A. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803582-5.00007-3 · Cited by 7 · see citing works
Exploring DNA damage responses in human cells with recombinant adenoviral vectors
Armelini, M. G., Lima-Bessa, K. M., Marchetto, M. C., Muotri, A. R., Chiganças, V., Leite, R. A., Carvalho, H., & Menck, C. F. M. (2007) · Human & Experimental Toxicology · doi:10.1177/0960327107083556 · Cited by 5 · see citing works
Expansion of the Genetic Alphabet: Unnatural Nucleobases and Their Applications
Bag, S. S., Heemstra, J. M., Saito, Y., & Chenoweth, D. M. (2012) · Journal of Nucleic Acids · doi:10.1155/2012/718582 · Cited by 3 · see citing works
The Response of the Replication Apparatus to Leading Template Strand Blocks
Bellani, M., Shaik, A., Majumdar, I., Ling, C., & Seidman, M. M. (2023) · Cells · doi:10.3390/cells12222607 · Cited by 2 · see citing works
Chemotherapeutic Intervention by Inhibiting DNA Polymerases
Berdis, A. J. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-384999-1.10005-8 · Cited by 1 · see citing works
Repair and Mutagenesis of DNA
Devoret, R. (2006) · Wiley-VCH eBooks · doi:10.1002/3527600906.mcb.200500026
Mecanismos de resistência à cloroquina em células de glioma humano e o uso de neurônios humanos derivados de células-tronco pluripotentes induzidas como modelo de estudo da síndrome de Cockayne.
Vessoni, A. T. (2015) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2015.tde-06102015-200543
Defective Solar Protection in Xeroderma Pigmentosum and Cockayne Syndrome Patients
Aprhys, C., & Judge, D. P. (2006) · Springer eBooks · doi:10.1007/0-387-36802-7_10
In Vitro Studies of Exchanges between Replicative and Translesion DNA Polymerases in the Eukaryotic Post-replication Repair Pathway
Masuda, Y. (2012) · Genes and Environment · doi:10.3123/jemsge.34.70

Xeroderma Pigmentosum — A Human Model of Defective DNA Repair
Friedberg, E. C. (1981) · Springer eBooks · doi:10.1007/978-1-4684-7956-0_37 · Cited by 3 · see citing works
Abnormal, Error-Prone Bypass of Photoproducts by Xeroderma Pigmentosum Variant Cell Extracts Results in Extreme Strand Bias for the Kinds of Mutations Induced by UV Light
McGregor, W. G., Dong, W., Maher, V. M., & McCormick, J. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.147 · Cited by 67 · see citing works
Xeroderma pigmentosum variants have decreased repair of ultraviolet-damaged DNA
DAY, R. S. (1975) · Nature · doi:10.1038/253748a0 · Cited by 70 · see citing works
Defective bypass replication of a leading strand cyclobutane thymine dimer in xeroderma pigmentosum variant cell extracts.
Svoboda, D. L., Briley, L. P., & Vos, J. H. (1998) · PubMed · Cited by 55 · see citing works
Dna Repair in Tumor Cells from the Variant form of Xeroderma Pigmentosum
Robbins, J. H., Kraemer, K. H., & Flaxman, B. A. (1975) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12533310 · Cited by 22 · see citing works

Authors: Cordonnier, A. M., & Fuchs, R. P. P.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Fuchs, Robert P.P
ORCID: Cordonnier, Agnes M
Fuchs, Robert P.P
Venue: Mutation Research/DNA Repair
Publisher: Elsevier BV
Published: 1999-10
Volume: 435
Issue: 2
Pages: 111-119
ISSN: 0921-8777 (ISSN-L)
DOI: 10.1016/s0921-8777(99)00047-6
OpenAlex: W2014999904
Cited by: 113
References: 67
Citations by year: 2026: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 10
FWCI: 3.68
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Mutation Research/DNA Repair (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords: DNA replication, DNA damage, thymine dimers, cyclobutane thymine dimers, postreplication repair, translesion synthesis, nucleotide excision repair, replication fork stalling, DNA polymerase, UV-induced DNA damage, skin cancer predisposition
MeSH terms: Animals, DNA Damage, DNA Replication, Humans, Xeroderma Pigmentosum

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Replication of damaged DNA: molecular defect in xeroderma pigmentosum variant cells

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