Noradrenergic depression of synaptic responses in hippocampus of rat: Evidence for mediation by alpha1-receptors
Abstract
Norepinephrine (NE) has been shown to have a biphasic effect on evoked potentials in the CA1 region of the hippocampus of the rat in vitro, with a beta receptor mediating an increase and an alpha receptor eliciting a decrease in the amplitude of the population spike. The purpose of this study was to use selective alpha-adrenergic agonists and antagonists to determine the subtype of receptor mediating the depressant response of NE. The present investigations demonstrated that the selective alpha 1 agonist, phenylephrine (2-50 microM) elicited a dose-dependent depression of the amplitude of the population spike. Clonidine, a relatively selective alpha 2-agonist, also depressed the amplitude of the population spike, but only at concentrations (10 microM) that were inconsistent with a selective action upon alpha 2-receptors. Another alpha 2-agonist, alpha-methylnorepinephrine (100-400 nM) did not depress the amplitude of the population spike. The depressant effect of NE was antagonized by the nonselective alpha antagonist, phentolamine (0.5-50 microM) and the alpha 1-selective antagonist, prazosin (1 microM), but not by the alpha 2-selective antagonist, idazoxan (1-10 microM). Phentolamine and prazosin antagonized the response to phenylephrine but not to clonidine. The depressant effect of NE was not antagonized by the antagonist of serotonin and dopamine, spiperone (100 nM); conversely, the effect of 8-hydroxy-2-(di-n-propylamine) tetralin (50 microM), a 5-HT1A receptor-selective agonist, which also depresses the amplitude of the population spike, was not antagonized by phentolamine (5 microM).(ABSTRACT TRUNCATED AT 250 WORDS)
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Noradrenaline reduces excitatory synaptic transmission by acting on α-adrenergic receptors.
“Noradrenaline increases the excitability of neurons that express β-adrenergic receptors187–189 and reduces excitatory synaptic transmission by acting on α-adrenergic receptors190,191”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [191]
Cites
Noradrenaline blocks accommodation of pyramidal cell discharge in the hippocampus
Madison, D. V., & Nicoll, R. A. (1982) · Nature · doi:10.1038/299636a0 · Cited by 581 · see citing works
U’Prichard, D. C., Greenberg, D. A., & Snyder, S. H. (1977) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)11222-4 · Cited by 554 · see citing works
Bennett, J. P., & Snyder, S. H. (1976) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10753-0 · Cited by 509 · see citing works
Burt, D. R., Creese, I., & Snyder, S. H. (1976) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10800-6 · Cited by 482 · see citing works
Dunwiddie, T. V., & LYNCH, G. S. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012239 · Cited by 479 · see citing works
Madison, D. V., & Nicoll, R. A. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016006 · Cited by 391 · see citing works
The action of norepinephrine in the rat hippocampus. I. Iontophoretic studies
Segal, M., & Bloom, F. E. (1974) · Brain Research · doi:10.1016/0006-8993(74)90652-0 · Cited by 387 · see citing works
Studies on RX 781094: a selective, potent and specific antagonist of α2‐adrenoceptors
Doxey, J. C., Roach, A. G., & SMITH, C. F. C. (1983) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1983.tb08809.x · Cited by 355 · see citing works
The action of norepinephrine in the rat hippocampus. II. Activation of the input pathway
Segal, M., & Bloom, F. E. (1974) · Brain Research · doi:10.1016/0006-8993(74)90653-2 · Cited by 310 · see citing works
Drew, G. M. (1976) · European Journal of Pharmacology · doi:10.1016/0014-2999(76)90084-4 · Cited by 292 · see citing works
Williams, J., Henderson, G., & North, R. A. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90166-6 · Cited by 262 · see citing works
The actions of noradrenaline on neurones of the rat substantia gelatinosa in vitro.
North, R. A., & Yoshimura, M. (1984) · The Journal of Physiology · doi:10.1113/jphysiol.1984.sp015141 · Cited by 251 · see citing works
Mueller, A. L., Hoffer, B. J., & Dunwiddie, T. V. (1981) · Brain Research · doi:10.1016/0006-8993(81)90442-x · Cited by 195 · see citing works
Modulation of a transient outward current in serotonergic neurones by α1-adrenoceptors
Aghajanian, G. K. (1985) · Nature · doi:10.1038/315501a0 · Cited by 180 · see citing works
Dopamine decreases the calcium-activated afterhyperpolarization in hippocampal CA1 pyramidal cells
Malenka, R. C., & Nicoll, R. A. (1986) · Brain Research · doi:10.1016/0006-8993(86)90773-0 · Cited by 114 · see citing works
Hippocampal noradrenergic responses in vivo and in vitro
Mueller, A. L., Palmer, M. R., Hoffer, B. J., & Dunwiddie, T. V. (1982) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00501163 · Cited by 94 · see citing works
Adrenoceptors on central neurones: Microelectrophoretic studies
Szabadi, E. (1979) · Neuropharmacology · doi:10.1016/0028-3908(79)90079-0 · Cited by 71 · see citing works
Comparison of dopamine receptor sites labeled by [3H]-S-sulpiride and [3H]-spiperone in striatum.
Zahniser, N. R., & Dubocovich, M. L. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22033-x · Cited by 69 · see citing works
Spiperone differentiates multiple 5-hydroxytryptamine responses in rat hippocampal slices in vitro
Beck, S. G., Clarke, W. P., & Goldfarb, J. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90206-7 · Cited by 66 · see citing works
LOVELL, R. A., & Freedman, D. X. (1976) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10797-9 · Cited by 54 · see citing works
Beck, S. G., & Goldfarb, J. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90637-x · Cited by 33 · see citing works
Peroutka, S. J., Mauk, M. D., & Kocsis, J. D. (1987) · Neuropharmacology · doi:10.1016/0028-3908(87)90201-2 · Cited by 29 · see citing works
Polyphosphoinositide Research Updated
Marx, J. L. (1987) · Science · doi:10.1126/science.2881351 · Cited by 28 · see citing works
Dopaminergic and noradrenergic responses in the hippocampal slice preparation
Marciani, M. G., Calabresi, P., Stanzione, P., & Bernardi, G. (1984) · Neuropharmacology · doi:10.1016/0028-3908(84)90191-6 · Cited by 22 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Neuromodulation and cortical function: modeling the physiological basis of behavior
Hasselmo, M. E. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(94)00113-t · Cited by 552 · see citing works
Mongeau, R., Blier, P., & de Montigny, C. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00017-3 · Cited by 391 · see citing works
Mechanisms underlying gain modulation in the cortex
Ferguson, K. A., & Cardin, J. A. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0253-y · Cited by 327 · see citing works
Noradrenergic Suppression of Synaptic Transmission May Influence Cortical Signal-to-Noise Ratio
Hasselmo, M. E., Linster, C., Patil, M., Ma, D., & Cekic, M. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.6.3326 · Cited by 229 · see citing works
Vagus nerve stimulation…25 years later! What do we know about the effects on cognition?
Vonck, K. E. J., Raedt, R., Naulaerts, J., Vogelaere, F. D., Thiery, E. W., Roost, D. V., Aldenkamp, A. P., Miatton, M., & Boon, P. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.05.005 · Cited by 187 · see citing works
Vagus nerve stimulation potentiates hippocampal LTP in freely-moving rats
Zuo, Y., Smith, D. C., & Jensen, R. A. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.11.009 · Cited by 135 · see citing works
Scanziani, M., Gahwiler, B., & Thompson, S. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-12-05393.1993 · Cited by 124 · see citing works
Synaptic localization of adrenergic disinhibition in the rat hippocampus
Doze, V. A., Cohen, G. A., & Madison, D. V. (1991) · Neuron · doi:10.1016/0896-6273(91)90229-s · Cited by 123 · see citing works
Actions of noradrenaline on neocortical neurons in vitro
Dodt, H.-U., Pawelzik, H., & Zieglga¨nsberger, W. (1991) · Brain Research · doi:10.1016/0006-8993(91)91303-i · Cited by 104 · see citing works
Sirviö, J., & MacDonald, E. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(99)00017-0 · Cited by 88 · see citing works
Scheiderer, C. L., Dobrunz, L. E., & McMahon, L. L. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00420.2003 · Cited by 84 · see citing works
Gustafson, I., Westerberg, E., & Wieloch, T. W. (1990) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1990.145 · Cited by 83 · see citing works
Heginbotham, L., & Dunwiddie, T. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-08-02519.1991 · Cited by 80 · see citing works
Actions of norepinephrine in the rat hippocampus
Segal, M., Markram, H., & Richter‐Levin, G. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)63819-4 · Cited by 71 · see citing works
Law-Tho, D., Crépel, F., & Hirsch, J. C. (1993) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1993.tb00217.x · Cited by 65 · see citing works
Shen, H., Fuchino, Y., Miyamoto, D., Nomura, H., & Matsuki, N. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000708 · Cited by 56 · see citing works
Zilles, K., Gross, G., Schleicher, A., Schildgen, S., Bauer, A., Bahro, M., Schwendemann, G., Zech, K., & Kolassa, N. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90122-5 · Cited by 55 · see citing works
Ego‐Stengel, V., Bringuier, V., & Shulz, D. E. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00011-8 · Cited by 53 · see citing works
Alpha-1A adrenergic receptor activation increases inhibitory tone in CA1 hippocampus
Hillman, K. L., Lei, S., Doze, V. A., & Porter, J. E. (2009) · Epilepsy Research · doi:10.1016/j.eplepsyres.2008.12.007 · Cited by 49 · see citing works
Carli, M., Silva, S., Balducci, C., & SAMANIN, R. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00038-6 · Cited by 46 · see citing works
Ura, H., Sugaya, Y., Ohata, H., Takumi, I., Sadamoto, K., Shibasaki, T., & Maru, E. (2012) · Brain Research · doi:10.1016/j.brainres.2012.11.024 · Cited by 41 · see citing works
Stimulation of alpha-1 adrenergic receptors facilitates spatial learning in rats
Puumala, T., Greijus, S., Narinen, K., Haapalinna, A., Riekkinen, P. J., & Sirviö, J. (1998) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(97)00040-0 · Cited by 41 · see citing works
Park, J.-Y., & Spruston, N. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6519-11.2012 · Cited by 37 · see citing works
Effects of noradrenaline on the firing rate of vestibular neurons
Licata, F., Volsi, G. L., Maugeri, G., Ciranna, L., & Santangelo, F. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90293-o · Cited by 35 · see citing works
Riekkinen, M., Stefański, R., Kuitunen, J., & Riekkinen, P. J. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00842-x · Cited by 33 · see citing works
Sara, S. J., & Bergis, O. E. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90356-x · Cited by 33 · see citing works
Pussinen, R., & Sirviö, J. (1999) · Journal of Psychopharmacology · doi:10.1177/026988119901300210 · Cited by 33 · see citing works
Yun, J. S. (2003) · Brain · doi:10.1093/brain/awg277 · Cited by 32 · see citing works
Andreasen, M., & Lambert, J. D. C. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018686 · Cited by 31 · see citing works
Mori-Okamoto, J., Namii, Y., & Tatsuno, J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90687-q · Cited by 29 · see citing works
Altered hippocampal network excitability in the hypernoradrenergic mutant mousetottering
Noebels, J. L., & Rutecki, P. A. (1990) · Brain Research · doi:10.1016/0006-8993(90)90695-8 · Cited by 29 · see citing works
Savola, M. K. T., MacIver, M. B., Doze, V. A., Kendig, J. J., & Maze, M. (1991) · Brain Research · doi:10.1016/0006-8993(91)91101-6 · Cited by 27 · see citing works
Su, M., Dunwiddie, T. V., & Gerhardt, G. A. (1990) · Brain Research · doi:10.1016/0006-8993(90)90966-f · Cited by 25 · see citing works
Pearson, T., & Frenguelli, B. G. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03602.x · Cited by 23 · see citing works
Granholm, A., ERIKSDOTTERNILSSON, M., Strömberg, I., Stieg, P. E., Seiger, A., Bygdeman, M., Geffard, M., Oertel, W. H., Dahl, D. R., & OLSON, L. (1989) · Experimental Neurology · doi:10.1016/s0014-4886(89)80010-x · Cited by 23 · see citing works
Kruman, I. I., Guo, Q., & Mattson, M. P. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19980201)51:3 · Cited by 377 · see citing works
Hillman, K. L., Doze, V. A., & Porter, J. E. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.119297 · Cited by 20 · see citing works
Antidepressant drugs potentiate the α1-adrenoceptor effect in hippocampal slices
Bijak, M. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90058-7 · Cited by 20 · see citing works
Eriksdotter, M., Gerhardt, G. A., Seiger, Å., Hoffer, B. J., & Granholm, A.-C. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90020-1 · Cited by 20 · see citing works
Riekkinen, M., Kemppainen, S., & Riekkinen, P. J. (1997) · Psychopharmacology · doi:10.1007/s002130050264 · Cited by 19 · see citing works
Hippocampal Transplants in Oculo: A Model for Establishment of Isolated Circuits
Granholm, A. (1991) · Methods in neurosciences · doi:10.1016/b978-0-12-185263-4.50027-3 · Cited by 19 · see citing works
Burnett, D. M., & Zahniser, N. R. (1989) · Synapse · doi:10.1002/syn.890040208 · Cited by 18 · see citing works
Ahmadirad, N., Fathollahi, Y., Janahmadi, M., Shojaei, A., Ghasemi, Z., Barkley, V., & Mirnajafi‐Zadeh, J. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.03.007 · Cited by 13 · see citing works
Niittykoski, M., Lappalainen, R. I., Jolkkonen, J., Haapalinna, A., Riekkinen, P. J., & Sirviö, J. (1998) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(98)00002-5 · Cited by 12 · see citing works
Bijak, M. (1995) · European Neuropsychopharmacology · doi:10.1016/0924-977x(94)00132-u · Cited by 10 · see citing works
Valtonen, P., Haapalinna, A., Riekkinen, P. J., & Halonen, T. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00405-a · Cited by 9 · see citing works
Ameri, A. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701608 · Cited by 8 · see citing works
Noradrenergic Profile of Hippocampal Formation Theta Rhythm in Anaesthetized Rats
Broncel, A., Bocian, R., Kłos‐Wojtczak, P., & Konopacki, J. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.08.008 · Cited by 8 · see citing works
Brito, G. N. O. (1992) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4615-9843-5_10 · Cited by 8 · see citing works
Adrenergic receptor systems and unscheduled DNA synthesis in the rat brain
Sadile, A. G., Lamberti-d'Mello, C., Cerbone, A., Amoroso, S., Annunziato, L., Menna, T., Buono, C., & Giuditta, A. (1995) · Brain Research Bulletin · doi:10.1016/0361-9230(94)00267-5 · Cited by 7 · see citing works
Mori-Okamoto, J., & Tatsuno, J. (1989) · Brain Research · doi:10.1016/0006-8993(89)90431-9 · Cited by 6 · see citing works
Mynlieff, M., & Dunwiddie, T. V. (1990) · Brain Research · doi:10.1016/0006-8993(90)90587-2 · Cited by 5 · see citing works
Self-citationGranholm, A., Bergman, H., Mackerlova, L., & Blomqvist, A. G. (1990) · Experimental Neurology · doi:10.1016/0014-4886(90)90123-a · Cited by 5 · see citing works
Alterations in $alpha;-adrenoceptors in aging intraocular hippocampal grafts
JONHAGEN, M. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00053-h · Cited by 4 · see citing works
Modulatory Influences on the Hippocampus and Entorhinal Cortex
Gupta, K., & Hasselmo, M. E. (2014) · Springer eBooks · doi:10.1007/978-3-7091-1292-2_7 · Cited by 3 · see citing works
Chronic intraventricular norepinephrine and delayed neuronal death in the hippocampus
Nishino, K., Kikuchi, K., Ohu, H., & Kowada, M. (1995) · Journal of Clinical Neuroscience · doi:10.1016/0967-5868(95)90009-8 · Cited by 2 · see citing works
Кичигина, В. Ф., Es, K., & Vv, S. (2004) · Neuroscience and Behavioral Physiology · doi:10.1023/b:neab.0000049658.44711.af · Cited by 2 · see citing works
Noradrenergic α1, α2, and β1receptors mediate VNS-induced theta oscillations
Bocian, R., Broncel, A., & Konopacki, J. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148266 · Cited by 2 · see citing works
Mynlieff, M., Curella, P., Zahniser, N. R., Gerhardt, G. A., Seiger, Å., & Dunwiddie, T. V. (1990) · Synapse · doi:10.1002/syn.890060202 · Cited by 2 · see citing works
Self-citationMaity, S. (2014) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3ff3m760 · Cited by 2 · see citing works
In Vitro Electrophysiological Analysis of in Oculo Transplants
Mynlieff, M., & Dunwiddie, T. V. (1991) · Methods in neurosciences · doi:10.1016/b978-0-12-185263-4.50034-0
Self-citation
- Authors
- Mynlieff, M.
- Affiliations
- University of Colorado Denver (US)
- Corresponding author
- Mynlieff, M
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 1988-04
- Volume
- 27
- Issue
- 4
- Pages
- 391-398
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2077413595
- Cited by
- 61
- References
- 24
- Citations by year
- 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2014: 3 · 2012: 2
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Rensselaer Polytechnic Institute
- National Institute on Drug Abuse (DA02702)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- norepinephrine, alpha1-adrenoceptors, alpha2-adrenoceptors, hippocampus, CA1 region, population spike, synaptic depression, phenylephrine, clonidine, prazosin, phentolamine, idazoxan, 5-HT1A receptor
- MeSH terms
- Animals, Evoked Potentials, Hippocampus, Male, Norepinephrine, Rats, Inbred Strains, Receptors, Adrenergic, alpha, Synapses, Rats, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
