The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Validity of the Vaginal Gram Stain for the Diagnosis of Bacterial Vaginosis
Abstract
OBJECTIVE: To determine the sensitivity and specificity of vaginal Gram stain as interpreted by the Nugent criteria for the diagnosis of bacterial vaginosis, and to consider the use of Gram stain as the criterion standard for the diagnosis of bacterial vaginosis. METHODS: A multicenter study was conducted of women attending gynecology or sexually transmitted disease clinics. Clinical data consisting of vaginal pH, "whiff test," clue cells, and appearance of the vaginal discharge (Amsel criteria) were compared with the vaginal fluid Gram stain (Nugent criteria) for the diagnosis of bacterial vaginosis. RESULTS: The sensitivity and specificity of the Gram stain compared with the Amsel criteria were 89 and 83%, respectively. There was significant variation in the specificity values by geographic site. If the Gram stain was considered the criterion standard for the diagnosis of bacterial vaginosis, the sensitivity and specificity of the Amsel criteria were 70 and 94%, respectively. CONCLUSION: The vaginal Gram stain (Nugent criteria) is a sensitive method for the diagnosis of bacterial vaginosis. The 83% specificity suggests that the currently used Amsel criteria may lead to the underdiagnosis of bacterial vaginosis.
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Cites
Statistical Methods for Rates and Proportions
Fleiss, J. L., Levin, B., & Paik, M. C. (2003) · Wiley Series in Probability and Statistics · doi:10.1002/0471445428 · Cited by 18,646
Nugent, R. P., Krohn, M. A., & Hillier, S. L. (1991) · Journal of Clinical Microbiology · doi:10.1128/jcm.29.2.297-301.1991 · Cited by 3,331
Amsel, R., Totten, P. A., Spiegel, C. A., Chen, K. C. S., Eschenbach, D., & Holmes, K. K. (1983) · The American Journal of Medicine · doi:10.1016/0002-9343(83)91112-9 · Cited by 2,349
Association between Bacterial Vaginosis and Preterm Delivery of a Low-Birth-Weight Infant
Hillier, S. L., Nugent, R. P., Eschenbach, D. A., Krohn, M. A., Gibbs, R. S., Martin, D. H., Cotch, M. F., Edelman, R., Pastorek, J. G., Rao, A. V., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199512283332604 · Cited by 1,492
Designing clinical research: An epidemiologic approach
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Diagnosis and clinical manifestations of bacterial vaginosis
Eschenbach, D. A., Hillier, S., Critchlow, C., Stevens, C., DeRouen, T., & Holmes, K. K. (1988) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(88)90078-6 · Cited by 549
Emerging Role of Lactobacilli in the Control and Maintenance of the Vaginal Bacterial Microflora
redondo-Lopez, V., Cook, R. L., & Sobel, J. D. (1990) · Clinical Infectious Diseases · doi:10.1093/clinids/12.5.856 · Cited by 545
Diagnosis of bacterial vaginosis by direct gram stain of vaginal fluid
Spiegel, C. A., Amsel, R., & Holmes, K. K. (1983) · Journal of Clinical Microbiology · doi:10.1128/jcm.18.1.170-177.1983 · Cited by 412
The preterm prediction study: significance of vaginal infections
Meis, P. J., Goldenberg, R. L., Mercer, B., Moawad, A., Das, A., McNellis, D., Johnson, F., Iams, J. D., Thom, E., & Andrews, W. W. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)91360-2 · Cited by 410
Characteristics of three vaginal flora patterns assessed Gram stain among pregnant women
Hillier, S. L., Krohn, M. A., Nugent, R. P., & Gibbs, R. S. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(92)91368-k · Cited by 207
Cited by
Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 3,018
Romero, R., Hassan, S. S., Gajer, P., Tarca, A. L., Fadrosh, D. W., Nikita, L., Galuppi, M., Lamont, R. F., Chaemsaithong, P., Miranda, J., et al. (2014) · Microbiome · doi:10.1186/2049-2618-2-4 · Cited by 852
Koumans, E. H., Sternberg, M., Bruce, C., McQuillan, G., Kendrick, J., Sutton, M., & Markowitz, L. E. (2007) · Sexually Transmitted Diseases · doi:10.1097/olq.0b013e318074e565 · Cited by 761
Randomized Trial of Lactin-V to Prevent Recurrence of Bacterial Vaginosis
Cohen, C. R., Wierzbicki, M. R., French, A. L., Morris, S., Newmann, S., Reno, H., Green, L., Miller, S., Powell, J., Parks, T., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1915254 · Cited by 377
Sexually transmitted infections and risk behaviours in women who have sex with women.
Fethers, K. (2000) · Sexually Transmitted Infections · doi:10.1136/sti.76.5.345 · Cited by 251
Metadata
- Authors
- SCHWEBKE, J.
- Venue
- Obstetrics & Gynecology
- Published
- 1996-10
- Volume
- 88
- Issue
- 4
- Pages
- 573-576
- ISSN
- 0029-7844 (ISSN-L)
- OpenAlex
- W2114629982
- Cited by
- 264
- References
- 14
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- closed
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