Clinical, genetic, and histologic features of the trichoonychodental (TOD) syndrome
Abstract
A syndrome of scanty, fine, curled hair, thin dysplastic nails, taurodontic molars, hypoplastic-hypomature enamel, dysplasia of dentin, and hypohidrosis segregating as an autosomal dominant trait is described in a Japanese family. The patients received repeated doses of tetracycline during odontogenesis which fortuitously assisted in interpreting the pathogenesis of the dentin defect. The condition was previously described as familial congenital ectodermal dysplasia by Westerholm and as odontogenesis imperfecta by Siirilä and Heikinheimo. It is suggested that the name trichoonychodental (TOD) syndrome is a better descriptive term for the condition.
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Similarities are found between tricho-onycho-dental dysplasia (TOD) and tricho-odonto-onychodysplasia with pili torti.
“Similarities are found between tricho-onycho-dental dysplasia (TOD) [Koshiba et al., 1978] and tricho-odonto-onychodysplasia with pili torti [Carey, 1982;personal communication to Freire-Maia and Pinheiro, 1984] and refer to patients observed in a unique family and to a single patient, respectively.”
From Ectodermal dysplasias: Clinical and molecular review (2009) · cites this paper as Koshiba et al., 1978
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- Authors
- Koshiba, H., Kimura, O., Nakata, M., & Witkop, C. J.
- Affiliations
- Tokyo Medical and Dental University (JP)
- Corresponding author
- Koshiba, Hiroaki
- Venue
- Oral Surgery, Oral Medicine, Oral Pathology
- Publisher
- Elsevier BV
- Published
- 1978-09
- Volume
- 46
- Issue
- 3
- Pages
- 376-385
- ISSN
- 0030-4220 (ISSN-L)
- OpenAlex
- W1980682527
- Cited by
- 37
- References
- 22
- Citations by year
- 2022: 1 · 2019: 2 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oral Surgery Oral Medicine Oral Pathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
- Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and rare skin diseases.
- Keywords
- ectodermal dysplasia, taurodontism, enamel hypoplasia, dentin dysplasia, hypohidrosis, tetracycline, autosomal dominant inheritance, nail dysplasia
- MeSH terms
- Chromosome Aberrations, Dentin Dysplasia, Ectodermal Dysplasia, Female, Humans, Male, Microradiography, Microscopy, Fluorescence, Pedigree, Sweat Glands, Syndrome, Tetracyclines, Tooth Abnormalities, Odontodysplasia, Chromosome Disorders
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