Cited by 37dental development and anomaliesBone and Dental Protein StudiesGenetic and rare skin diseases.

Clinical, genetic, and histologic features of the trichoonychodental (TOD) syndrome

Koshiba, Hiroaki, Kimura, Okio, Nakata, Minoru, Witkop, Carl J.·1978·Oral Surgery, Oral Medicine, Oral Pathology

Abstract

A syndrome of scanty, fine, curled hair, thin dysplastic nails, taurodontic molars, hypoplastic-hypomature enamel, dysplasia of dentin, and hypohidrosis segregating as an autosomal dominant trait is described in a Japanese family. The patients received repeated doses of tetracycline during odontogenesis which fortuitously assisted in interpreting the pathogenesis of the dentin defect. The condition was previously described as familial congenital ectodermal dysplasia by Westerholm and as odontogenesis imperfecta by Siirilä and Heikinheimo. It is suggested that the name trichoonychodental (TOD) syndrome is a better descriptive term for the condition.

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Crossref · 10.1016/0030-4220(78)90403-6

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22 of 22 references verified0 citation errors · 0 not checkable

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  • Similarities are found between tricho-onycho-dental dysplasia (TOD) and tricho-odonto-onychodysplasia with pili torti.

    “Similarities are found between tricho-onycho-dental dysplasia (TOD) [Koshiba et al., 1978] and tricho-odonto-onychodysplasia with pili torti [Carey, 1982;personal communication to Freire-Maia and Pinheiro, 1984] and refer to patients observed in a unique family and to a single patient, respectively.”

    From Ectodermal dysplasias: Clinical and molecular review (2009) · cites this paper as Koshiba et al., 1978

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Authors
Koshiba, H., Kimura, O., Nakata, M., & Witkop, C. J.
Affiliations
Tokyo Medical and Dental University (JP)
Corresponding author
Koshiba, Hiroaki
Venue
Oral Surgery, Oral Medicine, Oral Pathology
Publisher
Elsevier BV
Published
1978-09
Volume
46
Issue
3
Pages
376-385
ISSN
0030-4220 (ISSN-L)
OpenAlex
W1980682527
Cited by
37
References
22
Citations by year
2022: 1 · 2019: 2 · 2015: 1 · 2014: 1 · 2012: 1
FWCI
0.73
Type
journal article
Language
en
Open access
closed
Locations
  • Oral Surgery Oral Medicine Oral Pathology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
  • Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and rare skin diseases.
Keywords
ectodermal dysplasia, taurodontism, enamel hypoplasia, dentin dysplasia, hypohidrosis, tetracycline, autosomal dominant inheritance, nail dysplasia
MeSH terms
Chromosome Aberrations, Dentin Dysplasia, Ectodermal Dysplasia, Female, Humans, Male, Microradiography, Microscopy, Fluorescence, Pedigree, Sweat Glands, Syndrome, Tetracyclines, Tooth Abnormalities, Odontodysplasia, Chromosome Disorders

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