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Cited by 54Birth, Development, and HealthNeuroendocrine regulation and behaviorPrenatal Substance Exposure Effects

Prenatal protein malnutrition affects the social interactions of juvenile rats

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Almeida, S.S., Tonkiss, J., Galler, J.R.·1996·Physiology & Behavior
DOI 10.1016/0031-9384(95)02236-8
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Abstract

The effects of prenatal protein malnutrition on juvenile social behavior was investigated in male and female rats. Animals were provided with 25% (control) or 6% (low protein) casein diets before and during pregnancy. After birth eight pups in each litter (six males and two females) were fostered to lactating control mothers. After weaning (21 days of age) all animals received a lab chow diet until behavioral testing began at 45 days of age. To assess social interaction, pairs of rats of the same gender, consisting of one malnourished and one control rat, were placed in a familiar rectangular arena on 3 consecutive days. Playful social behavior (pin), nonplayful social behaviors (anogenital sniff, walk-over, side-mount, and allogroom), and nonsocial behavior (rear) were recorded in 10-min sessions. Prenatal malnutrition significantly decreased both playful and nonplayful social behaviors, and increased nonsocial rearing. No significant gender differences were observed. The finding that early social behavior is altered by prenatal malnutrition opens the possibility that such changes may play an important role in determining some of the later behavioral differences described in the adult animal.

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  • Other manipulations such as prenatal protein deprivation, perinatal genistein exposure, prenatal PCB exposure, or maternal stress during gestation can also demasculinize play behavior.

    “Other manipulations such as prenatal protein deprivation (Almeida et al. 1996), perinatal genistein exposure (Flynn et al. 2000), prenatal polychlorinated biphenyl (PCB) exposure (Vreugdenhil et al. 2002), or maternal stress during gestation can also demasculinize play behavior (Ward and Stehm 1991).”

    From Perinatal Exposure to Low Levels of the Environmental Antiandrogen Vinclozolin Alters Sex-Differentiated Social Play and Sexual Behaviors in the Rat (2005) · cites this paper as Almeida et al. 1996

    The Behavioral Measures section reports that prenatal protein malnutrition reduced pinning, a measure of juvenile social play, on test sessions 2 and 3. But it found no significant effect of sex or interaction involving sex, so the reduction does not establish that play behavior was specifically demasculinized. No page number is available in our copy. (LLM, conf=0.88)

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Research works printed but not linked: 3

  1. Poole T. B.; Fish, J. An investigation of individual, age, and sexual differences in the play of Rattus norvergicus (Mammalia: Rodentia). Proc. Zool. Soc. Lond. 179:249-260; 1976,
  2. Rozenzweig, M. R. Effects of environment on development of brain and behavior. In: Tobach, E.; Aronson, L. R.; Shaw, E., eds. The biopsychology of development. New York: Academic Press; 1971:303-342.
  3. Smart, J. L. Undernutrition and aggression. In: Brain, P. F.; Benton, D., eds. Multidisciplinary approaches to aggression research. Amster- dam: Elsiever/North Holland Biomedical Press; 1981:179-191.

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Authors
Almeida, S. S., Tonkiss, J., & Galler, J. R.
Affiliations
  • Universidade de São Paulo (BR)
  • Boston University (US)
Corresponding author
Tonkiss, J.
ORCID
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
1996-07
Volume
60
Issue
1
Pages
197-201
ISSN
0031-9384 (ISSN-L)
DOI
10.1016/0031-9384(95)02236-8
OpenAlex
W2067427725
Cited by
54
References
34
Citations by year
2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 3
FWCI
1.77
Type
journal article
Language
en
Open access
Licence
Locations
  • Physiology & Behavior (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (30000/91-1)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (400015/91-9, 530060/93-0, 93/1538-9)
  • National Institutes of Health (HD22539, DA07934, 90/3474-0)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
prenatal protein malnutrition, social behavior, young rats, play behavior, casein diet, low-protein diet, gender differences, developmental origins of behavior
MeSH terms
Agonistic Behavior, Animals, Brain, Female, Grooming, Male, Motor Activity, Play and Playthings, Pregnancy, Prenatal Exposure Delayed Effects, Protein-Energy Malnutrition, Social Behavior, Social Environment, Rats, Wistar, Rats

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