The DOI matches its Crossref record.
Zika virus (II). Pathogenicity and physical properties
Abstract
(1) A description is given of the adaptation to mice of two strains of Zika virus. Zika is the name of a forest area near Entebbe, Uganda, where both strains of virus were isolated. One of the strains was isolated from a pyrexial rhesus monkey which was being employed as a yellow fever sentinel and the other was obtained from a batch of A. africanus. (2) The signs of infection in mice are described. While mice of all ages tested are susceptible to intracerebral inoculations with Zika mouse brain virus, mice of 2 weeks of age and over can rarely be infected by the intraperitoneal route. Mice younger than 2 weeks are highly susceptible to intraperitoneal inoculation of the virus. (3) Zika virus is highly neurotropic in mice and no virus has been recovered from tissues other than the brains of infected mice. (4) Cotton-rats, guineapigs and rabbits show no clinical signs of infection after intracerebral inoculation of late passage mouse brain virus. (5) Monkeys develop an inapparent infection after subcutaneous inoculation with mouse brain virus. After intracerebral inoculation one of five monkeys showed a mild pyrexia, the others showed no signs of infection. Viraemia during the first week after inoculation has been found in all monkeys tested and antibody has been demonstrated by the 14th day after inoculation. (6) Of 99 human sera tested, 6 (6.1 per cent.)-have neutralized more than 100 LD50 of virus. Antibody has also been found in the serum of one of 15 wild monkeys tested. (7) The size of Zika virus is estimated to eb in the region of 30 to 45 mμ in diameter. The virus may be preserved up to 6 months in 50 per cent. glycerol and up to 30 months after drying. It is susceptible to anaesthetic ether and the thermal death point is 58°C. for 30 minutes. (8) Neuronal degeneration, cellular infiltration and areas of softening are present in infected mouse brains. Cowdry type A inclusion bodies have been found, particularly in the brains of young mice showing extensive lesions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Musso, D., & Gubler, D. J. (2016) · Clinical Microbiology Reviews · doi:10.1128/cmr.00072-15 · Cited by 1,469
Zika virus impairs growth in human neurospheres and brain organoids
Garcez, P. P., Loiola, E. C., Madeiro da Costa, R., Higa, L. M., Trindade, P., Delvecchio, R., Nascimento, J. M., Brindeiro, R., Tanuri, A., & Rehen, S. K. (2016) · Science · doi:10.1126/science.aaf6116 · Cited by 1,184
A Mouse Model of Zika Virus Pathogenesis
Lazear, H. M., Govero, J., Smith, A. M., Platt, D. J., Fernandez, E., Miner, J. J., & Diamond, M. S. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.03.010 · Cited by 909
Modified mRNA vaccines protect against zika virus infection
Richner, J. M., Himansu, S., Dowd, K. A., Butler, S. L., Salazar, V., Fox, J. M., Julander, J. G., Tang, W. W., Shresta, S., Pierson, T. C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.02.017 · Cited by 909
Genetic Characterization of Zika Virus Strains: Geographic Expansion of the Asian Lineage
Haddow, A. D., Schuh, A. J., Yasuda, C. Y., Kasper, M. R., Heang, V., Huy, R., Guzman, H., Tesh, R. B., & Weaver, S. C. (2012) · PLoS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0001477 · Cited by 773
Metadata
- Authors
- Dick, G. W. A.
- Venue
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publisher
- Oxford University Press (OUP)
- Published
- 1952-09
- Volume
- 46
- Issue
- 5
- Pages
- 521-534
- ISSN
- 0035-9203 (ISSN-L)
- OpenAlex
- W2117649585
- Cited by
- 688
- References
- 0
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Zika virus (II). Pathogenicity and physical properties. https://app.cochat.ai/papers/10.1016/0035-9203(52)90043-6
- The paper
- Dick, G. W. A. (1952). Zika virus (II). Pathogenicity and physical properties. Transactions of the Royal Society of Tropical Medicine and Hygiene. https://doi.org/10.1016/0035-9203(52)90043-6
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
